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Palomar Gattini-IR is a new wide-field, near-infrared (NIR) robotic time domain survey operating at Palomar Observatory. Using a 30 cm telescope mounted with a H2RG detector, Gattini-IR achieves a field of view (FOV) of 25 sq. deg. with a pixel scale of 8 7 in J-band. Here, we describe the system design, survey operations, data processing system and on-sky performance of Palomar Gattini-IR. As a part of the nominal survey, Gattini-IR scans 7500 square degrees of the sky every night to a median 5 depth of 15.7 AB mag outside the Galactic plane. The survey covers 15,000 square degrees of the sky visible from Palomar with a median cadence of 2 days. A real-time data processing system produces stacked science images from dithered raw images taken on sky, together with point-spread function (PSF)-fit source catalogs and transient candidates identified from subtractions within a median delay of 4 hr from the time of observation. The calibrated data products achieve an astrometric accuracy (rms) of 0 7 with respect to Gaia DR2 for sources with signal-to-noise ratio > 10, and better than 0 35 for sources brighter than 12 Vega mag. The photometric accuracy (rms) achieved in the PSF-fit source catalogs is better than 3% for sources brighter than 12 Vega mag and fainter than the saturation magnitude of 8.5 Vega mag, as calibrated against the Two Micron All Sky Survey catalog. The detection efficiency of transient candidates injected into the images is better than 90% for sources brighter than the 5 limiting magnitude. The photometric recovery precision of injected sources is 3% for sources brighter than 13 mag, and the astrometric recovery rms is 0 9. Reference images generated by stacking several field visits achieve depths of 16.5 AB mag over 60% of the sky, while it is limited by confusion in the Galactic plane. With a FOV 40× larger than any other existing NIR imaging instrument, Gattini-IR is probing the reddest and dustiest transients in the local universe such as dust obscured supernovae in nearby galaxies, novae behind large columns of extinction within the galaxy, reddened microlensing events in the Galactic plane and variability from cool and dust obscured stars. We present results from transients and variables identified since the start of the commissioning period.

Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous melanoma. Similarly, vitamin D levels have been shown to be protective for risk of a number of conditions, including cardiovascular disease and chronic kidney disease, as well as numerous autoimmune disorders such as multiple sclerosis, inflammatory bowel diseases and type 1 diabetes mellitus. A study performed by Parekh et al. was the first to suggest a role for vitamin D in age-related macular degeneration (AMD) and showed a correlation between reduced serum vitamin D levels and risk for early AMD. Based on this study and the protective role of vitamin D in diseases with similar pathophysiology to AMD, we examined the role of vitamin D in a family-based cohort of 481 sibling pairs. Using extremely phenotypically discordant sibling pairs, initially we evaluated the association of neovascular AMD and vitamin D/sunlight-related epidemiological factors. After controlling for established AMD risk factors, including polymorphisms of the genes encoding complement factor H ( CFH ) and age-related maculopathy susceptibility 2/HtrA serine peptidase ( ARMS2/HTRA1 ), and smoking history, we found that ultraviolet irradiance was protective for the development of neovascular AMD ( p = 0.001). Although evaluation of serum vitamin D levels (25-hydroxyvitamin D [25(OH)D]) was higher in unaffected individuals than in their affected siblings, this finding did not reach statistical significance. Based on the relationship between ultraviolet irradiance and vitamin D production, we employed a candidate gene approach for evaluating common variation in key vitamin D pathway genes (the genes encoding the vitamin D receptor [ VDR ]; cytochrome P450, family 27, subfamily B, polypeptide 1 [ CYP27B1 ]; cytochrome P450, family 24, subfamily A, polypeptide 1 [ CYP24A1 ]; and CYP27A1 ) in this same family-based cohort. Initial findings were then validated and replicated in the extended family cohort, an unrelated case-control cohort from central Greece and a prospective nested case-control population from the Nurse's Health Study and Health Professionals Follow-Up Studies, which included patients with all subtypes of AMD for a total of 2,528 individuals. Single point variants in CYP24A1 (the gene encoding the catabolising enzyme of the vitamin D pathway) were demonstrated to influence AMD risk after controlling for smoking history, sex and age in all populations, both separately and, more importantly, in a meta-analysis. This is the first report demonstrating a genetic association between vitamin D metabolism and AMD risk. These findings were also supplemented with expression data from human donor eyes and human retinal cell lines. These data not only extend previous biological studies in the AMD field, but further emphasise common antecedents between several disorders with an inflammatory/immunogenic component such as cardiovascular disease, cancer and AMD.

The Zwicky Transient Facility (ZTF), a public-private enterprise, is a new time-domain survey employing a dedicated camera on the Palomar 48-inch Schmidt telescope with a 47 deg2 field of view and an 8 second readout time. It is well positioned in the development of time-domain astronomy, offering operations at 10% of the scale and style of the Large Synoptic Survey Telescope (LSST) with a single 1-m class survey telescope. The public surveys will cover the observable northern sky every three nights in g and r filters and the visible Galactic plane every night in g and r. Alerts generated by these surveys are sent in real time to brokers. A consortium of universities that provided funding (\"partnership\") are undertaking several boutique surveys. The combination of these surveys producing one million alerts per night allows for exploration of transient and variable astrophysical phenomena brighter than r ∼ 20.5 on timescales of minutes to years. We describe the primary science objectives driving ZTF, including the physics of supernovae and relativistic explosions, multi-messenger astrophysics, supernova cosmology, active galactic nuclei, and tidal disruption events, stellar variability, and solar system objects.

The Zwicky Transient Facility (ZTF) is a new optical time-domain survey that uses the Palomar 48 inch Schmidt telescope. A custom-built wide-field camera provides a 47 deg2 field of view and 8 s readout time, yielding more than an order of magnitude improvement in survey speed relative to its predecessor survey, the Palomar Transient Factory. We describe the design and implementation of the camera and observing system. The ZTF data system at the Infrared Processing and Analysis Center provides near-real-time reduction to identify moving and varying objects. We outline the analysis pipelines, data products, and associated archive. Finally, we present on-sky performance analysis and first scientific results from commissioning and the early survey. ZTF's public alert stream will serve as a useful precursor for that of the Large Synoptic Survey Telescope.

Palomar Gattini-IR is a new wide-field, near-infrared (NIR) robotic time domain survey operating at Palomar Observatory. Using a 30 cm telescope mounted with a H2RG detector, Gattini-IR achieves a field of view (FOV) of 25 sq. deg. with a pixel scale of 8″.7 in J-band. Here, we describe the system design, survey operations, data processing system and on-sky performance of Palomar Gattini-IR. As a part of the nominal survey, Gattini-IR scans ≈7500 square degrees of the sky every night to a median 5σ depth of 15.7 AB mag outside the Galactic plane. The survey covers ≈15,000 square degrees of the sky visible from Palomar with a median cadence of 2 days. A real-time data processing system produces stacked science images from dithered raw images taken on sky, together with point-spread function (PSF)-fit source catalogs and transient candidates identified from subtractions within a median delay of ≈4 hr from the time of observation. The calibrated data products achieve an astrometric accuracy (rms) of ≈0″.7 with respect to Gaia DR2 for sources with signal-to-noise ratio > 10, and better than ≈0″.35 for sources brighter than ≈12 Vega mag. The photometric accuracy (rms) achieved in the PSF-fit source catalogs is better than ≈3% for sources brighter than ≈12 Vega mag and fainter than the saturation magnitude of ≈8.5 Vega mag, as calibrated against the Two Micron All Sky Survey catalog. The detection efficiency of transient candidates injected into the images is better than 90% for sources brighter than the 5σ limiting magnitude. The photometric recovery precision of injected sources is 3% for sources brighter than 13 mag, and the astrometric recovery rms is ≈0″.9. Reference images generated by stacking several field visits achieve depths of ≳16.5 AB mag over 60% of the sky, while it is limited by confusion in the Galactic plane. With a FOV ≈40× larger than any other existing NIR imaging instrument, Gattini-IR is probing the reddest and dustiest transients in the local universe such as dust obscured supernovae in nearby galaxies, novae behind large columns of extinction within the galaxy, reddened microlensing events in the Galactic plane and variability from cool and dust obscured stars. We present results from transients and variables identified since the start of the commissioning period.

Information on chest imaging in patients with suspected COVID-19 is presented. Chest imaging is not routinely recommended to diagnose coronavirus disease 2019 (COVID-19) in patients with mild features. In patients with risk factors for disease progression, chest radiography, together with clinical symptoms, may inform whether to follow up in the community or to refer to secondary care.

The Zwicky Transient Facility (ZTF), a public–private enterprise, is a new time-domain survey employing a dedicated camera on the Palomar 48-inch Schmidt telescope with a 47 deg² field of view and an 8 second readout time. It is well positioned in the development of time-domain astronomy, offering operations at 10% of the scale and style of the Large Synoptic Survey Telescope (LSST) with a single 1-m class survey telescope. The public surveys will cover the observable northern sky every three nights in g and r filters and the visible Galactic plane every night in g and r. Alerts generated by these surveys are sent in real time to brokers. A consortium of universities that provided funding (“partnership”) are undertaking several boutique surveys. The combination of these surveys producing one million alerts per night allows for exploration of transient and variable astrophysical phenomena brighter than r ∼ 20.5 on timescales of minutes to years. We describe the primary science objectives driving ZTF, including the physics of supernovae and relativistic explosions, multi-messenger astrophysics, supernova cosmology, active galactic nuclei, and tidal disruption events, stellar variability, and solar system objects.

SPIRITS--the SPitzer InfraRed Intensive Transients Survey--searched for luminous infrared (IR) transients and variables in nearly 200 nearby galaxies from 2014 to 2019, using the warm Spitzer telescope at 3.6 and 4.5 microns. Among the SPIRITS variables are IR-bright objects that are undetected in ground-based optical surveys. We classify them as (1) transients, (2) periodic variables, and (3) irregular variables. The transients include \"SPRITE\"s (eSPecially Red Intermediate-luminosity Transient Events), having maximum luminosities fainter than supernovae, red IR colors, and a wide range of outburst durations (days to years). Here we report deep optical and near-IR imaging with the Hubble Space Telescope (HST) of 21 SPIRITS variables. They were initially considered SPRITE transients, but many eventually proved instead to be periodic or irregular variables as more data were collected. HST images show most of these cool and dusty variables are associated with star-forming regions in late-type galaxies, implying an origin in massive stars. Two SPRITEs lacked optical progenitors in deep pre-outburst HST images; however, one was detected during eruption at J and H, indicating a dusty object with an effective temperature of ~1050 K. One faint SPRITE turned out to be a dusty classical nova. About half the HST targets proved to be periodic variables, with pulsation periods of 670-2160 days; they are likely dusty asymptotic-giant-branch (AGB) stars with masses of ~5-10 Msun. A few of them were warm enough to be detected in deep HST frames, but most are too cool. Out of six irregular variables, two were red supergiants with optical counterparts in HST images; four were too enshrouded for HST detection.

M31-2015-LRN is a likely stellar merger discovered in the Andromeda Galaxy in 2015. We present new optical to mid-infrared photometry and optical spectroscopy for this event. Archival data shows that the source started to brighten \\(\\sim\\)2 years before the nova event. During this precursor phase, the source brightened by \\(\\sim\\)3 mag. The lightcurve at 6 and 1.5 months before the main outburst may show periodicity, with periods of 16\\(\\pm\\)0.3 and 28.1\\(\\pm\\)1.4 days respectively. This complex emission may be explained by runaway mass loss from the system after the binary undergoes Roche-lobe overflow, leading the system to coalesce in tens of orbital periods. While the progenitor spectral energy distribution shows no evidence of pre-existing warm dust in system, the remnant forms an optically thick dust shell at \\(\\sim\\)4 months after the outburst peak. The optical depth of the shell increases dramatically after 1.5 years, suggesting the existence of shocks that enhance the dust formation process. We propose that the merger remnant is likely an inflated giant obscured by a cooling shell of gas with mass \\(\\sim0.2\\) M\\(_{\\odot}\\) ejected at the onset of the common envelope phase.