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result(s) for
"Amstutz, Lisa J"
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Ancient Egypt
\"In Ancient Egypt, readers discover the history and impressive accomplishments of the people of ancient Egypt, including their extraordinary cultural achievements and feats of construction. Engaging text provides details on the civilization's history, development, daily life, culture, art, technology, warfare, social organization, and more.\"--Publisher's website.
Book
Living the local food lifestyle.(Roots Market & Cafe in downtown Wooster, Ohio)
Thanks to the new Local Roots Market & Cafe in downtown Wooster (population 26,000), even in the heart of winter, shoppers can now purchase locally and sustainably grown salad greens, squash, honey, meat, dairy products, baked goods and much more.
Magazine Article
Enchanted gardening : growing miniature gardens, fairy gardens, and more
\"Provides readers with projects for fairy gardens and other magical gardens\"-- Provided by publisher.
Book
Creative gardening : growing plants upside down, in water, and more
\"Provides readers with unique and unusual gardening projects\"-- Provided by publisher.
Book
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer
Colin Ross and colleagues report the results of a genome-wide association study of anthracycline-induced cardiotoxicity in children treated for cancer. They identify a nonsynonymous coding variant in
RARG
associated with roughly fivefold higher risk of developing this severe adverse drug reaction.
Anthracyclines are used in over 50% of childhood cancer treatment protocols
1
, but their clinical usefulness is limited by anthracycline-induced cardiotoxicity (ACT) manifesting as asymptomatic cardiac dysfunction and congestive heart failure in up to 57% and 16% of patients, respectively
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,
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. Candidate gene studies have reported genetic associations with ACT
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, but these studies have in general lacked robust patient numbers, independent replication or functional validation. Thus, the individual variability in ACT susceptibility remains largely unexplained
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,
13
. We performed a genome-wide association study in 280 patients of European ancestry treated for childhood cancer, with independent replication in similarly treated cohorts of 96 European and 80 non-European patients. We identified a nonsynonymous variant (rs2229774, p.Ser427Leu) in
RARG
highly associated with ACT (
P
= 5.9 × 10
−8
, odds ratio (95% confidence interval) = 4.7 (2.7–8.3)). This variant alters RARG function, leading to derepression of the key ACT genetic determinant
Top2b
, and provides new insight into the pathophysiology of this severe adverse drug reaction.
Journal Article
Birds
Tweet! Tweet! Birds make fun pets. Some are small and some are tall; some are colorful and some have crests. Young readers will learn about the appearance, behavior, and abilities of pet birds, and discover why these feathered friends make amazing pets.
Book
Cats
\"Young readers will learn about the appearance, behavior, and abilities of pet cats, and discover why these curious creatures make amazing pets\"-- Provided by publisher.
Book
