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\"Photographer Michael Arnaud spotlights green spaces and sustainable living in Paris\"--Back cover.

Consumption of aflatoxin‐contaminated food is responsible for hepatotoxicity. Dichrocephala integrifolia ( D. integrifolia ) is used in traditional African medicine to treat various liver diseases. This study aimed to evaluate the therapeutic effects of aqueous leaf extract of D. integrifolia on aflatoxin‐containing peanut‐induced liver damage in Wistar rats. The animals were fed the standard diet (SD) or the SD supplemented with stored and poorly preserved peanuts (50:50) containing aflatoxins for 42 days. Then, animals received the diet concomitantly with D. integrifolia (100, 200 mg/kg), or Silybon 100 mg/kg for 14 days. At the end of the experimental period, biochemical markers, including the lipid profile, liver function markers, and proinflammatory markers, were evaluated. A histopathological analysis of the liver was performed. Semiquantitative evaluation of aflatoxin B1 in peanuts by thin‐layer chromatography was carried out, and phytochemical characterization of the extract by high‐performance liquid chromatography–mass spectrometry was performed. As a result, poorly stored peanuts contain 20 μg/kg aflatoxin B1/kg of peanuts. Consumption of contaminated peanuts resulted in inflammation characterized by a significant increase ( p < 0.001) in proinflammatory cytokines (TNF‐α, INF‐γ, and IL‐13) and a significant increase ( p < 0.001) in transaminase activities, GGT, ALP, and levels of total bilirubin, total cholesterol, triglycerides, LDL cholesterol, and a significant decrease ( p < 0.001) in HDL cholesterol and albumin levels. These various abnormalities were accompanied by a significant increase ( p < 0.001) in oxidative stress. These disturbances were confirmed by hepatic cytolysis, leukocyte infiltration, and vascular congestion. Treatment with D. integrifolia extract at all doses tested reversed these abnormalities. These beneficial effects of the extract could be due to β ‐amyrin formate, identified in this extract, and could therefore justify the use of this plant extract in traditional medicine to manage liver diseases.

Phytoestrogens are used to ease postmenopausal symptoms, a property probably due to estrogenic and antioxidant effects. Pterocarpus soyauxii (P. soyauxii) is empirically used in Cameroon to treat among others primary and secondary amenorrhea. The aim of this study is to evaluate estrogenic and antioxidant activities of P. soyauxii heartwood aqueous extract in bilateral oophorectomized Wistar rats. Firstly, a characterization of the extract was carried out. For that, flavonoids, phenols, and tannins levels in P. soyauxii extract were evaluated by colorimetric assays and UHPLC-MS analysis was realized. In vitro antioxidant analysis of P. soyauxii was conducted using DPPH, ABTS, and FRAP assays. Secondly, 2 sets of pharmacologic tests were carried out. The results revealed that P. soyauxii aqueous extract contains, respectively, 229.42 ± 3.62 mg EAG/g, 63.42 ± 2.16 mg EQ/g, and 27.88 ± 0.23 mg ETA/g of polyphenols, flavonoids, and tannins. UHPLC-MS enabled identifying seven components including mono(2-ethylhexyl) phthalate, cembrene, 3′,5′-dimethoxy-4-stilbenol, and linoleic acid. DPPH, ABTS, and FRAP assays revealed that P. soyauxii extract possessed a high antioxidant activity with IC50 value of 730.20 µg/mL, 892.90 µg/mL, and 765.75 mEAG/g of extract, respectively. In the uterotrophic assay, P. soyauxii extract induced significant increase of fresh uterine weight, uterine and vaginal epithelial size, and mammary glands differentiation compared to Ovx control. In the postmenopausal model, compared to the sham control, vagina and uterine dystrophies were observed in Ovx rats treated with distilled water. P. soyauxii aqueous extract expressed estrogenic-like effects on vagina and did not affect uterine epithelial height compared with vehicle groups. On the back of these vaginotrophic effects, the extract displayed antiatherogenic properties by reducing (p < 0.001) AI and LDL cholesterol level as compared to Ovx control group. The extract at 200 mg/kg significantly prevented the increase of MDA (p < 0.01) level and decreased nitrites (p < 0.001) and GSH (p < 0.01) levels compared to Ovx rats. These beneficial effects are related at least in part to the presence of compound such as mono(2-ethylhexyl) phthalate, 3′,5′-dimethoxy-4-stilbenol, and linoleic acid. Overall, P. soyauxii aqueous extract exhibits estrogenic and antioxidant effects which can inhibit postmenopausal symptoms by providing vaginal stratification, improving lipid profile and insulin sensitivity, and reducing oxidative stress without side effects on the endometrium and mammary gland in 84-day Ovx rats.

\"What are New York City's best apartment buildings? Before 1900, it was the Dakota and the Osborne; soon after came McKim, Mead & White's 998 Fifth and the ultra-soigne 820 Fifth Avenue. The roaring twenties produced true luxury: 740 Park Avenue, the art deco-inspired River House, and Rosario Candela's extraordinary 778 and 720 Park Avenue. Today, the city's skyline sparkles with palatial new buildings, such as Robert A. M. Stern's 15 Central Park West, Richard Meier's glass-walled Perry Street towers, and 432 Park Avenue, New York's tallest residential building. Kirk Henckels and Anne Walker, real estate and architectural insiders, chronicle the fortunes and features of 15 outstanding apartment houses with a wealth of vintage and new photography and architectural plans, and show off select apartments as they look today, designed by top interior designers\"-- Provided by publisher.

The escalating challenge of malaria management, primarily driven by antimalarial drug resistance, necessitates the urgent exploration of novel therapeutic agents. This investigation focused on characterizing the therapeutic efficacy of an aqueous stem bark extract derived from Enantia chlorantha Oliv (Annonaceae) against the parasitic burden of Plasmodium berghei in a rodent model. Comprehensive assessment revealed noteworthy in vitro antiplasmodial efficacy against both the PfDd2 and Pf3D7 strains of P. falciparum , evidenced by median inhibitory concentrations (IC50) of 1.002 and 19.040 μg/mL, respectively. Moreover, the extract demonstrated a statistically significant, dose–responsive suppression of parasitemia in the in vivo model ( p < 0.001), achieving suppression rates between 79.00% and 96.91%. Critically, the administration of the extract mitigated malaria‐associated pathophysiology, including the prevention of cachexia, anemia, and elevated leukocyte counts. It concurrently facilitated the functional recovery of hepatic and renal biomarkers (e.g., transaminases, bilirubin, and creatinine), reversed indicators of cellular oxidative stress, and potentially lessened multiorgan structural damage. Collectively, these preclinical findings robustly support the substantial antimalarial capacity of E. chlorantha stem bark extract, providing scientific validation for its ethnobotanical application. Future pharmacological research is now imperative to isolate and chemically identify the specific phytochemical constituents responsible for these observed bioactivities.

Design Brooklyn is a visual exploration of the unique and diverse architecture, interiors, and design of public and private spaces in today's Brooklyn, from mechanics' shops renovated into restaurants, to newly built museums, to restored brownstones and modern townhouses. Chapters focusing on renovation, restoration, innovation, and industry come to life with more than 150 original photographs representing various neighborhoods and trends. Including studies of the Brooklyn Academy of Music's newest addition, Fort Greene Park, and Boerum Hill's Flavor Paper, Design Brooklyn will appeal to anyone interested in urban living, design, and trendsetting Brooklyn style. Praise for Design Brooklyn: \"A terrific book. Anne Hellman and Michel Arnaud perfectly capture the essence of the innovative, independent style of the creative people who define Brooklyn!\" -Wendy Goodman, Design Editor, New York magazine   \"Brooklyn's design identity is captured in this inspired collection of projects that takes you from the manufacturing past of the Brooklyn Navy Yard to influential architect-designed new construction, with plenty of bespoke brownstone renovations and handmade artists' studios in the mix.\" -Francesca Connolly, New York editor of Remodelista.com   \"The creativity that New York City is so known for seemed synonymous with Manhattan . . . that was until Brooklyn bloomed. And boy, has it bloomed!\" -Newell Turner, editor in chief, Hearst Design Group   \"Brooklyn's cutting-edge creativity, beauty, and bold self-confidence are well represented in this extraordinary book of Brooklyn design. Brooklyn has more character and characters than anywhere else in the world, and that spirit of originality and sense of history is vibrant and alive in these homes and cultural institutions.\" -Marty Markowitz, Brooklyn borough president   \"No sleep till you devour Design Brooklyn-a thrilling guide to architecture and décor in the mythical New York City borough. From a Beastie Boy's clever brownstone renovation to insider tours of cultural spaces and imaginative restaurant design, this stunning and idea-packed guide to Brooklyn design shows how wonderfully the old can meld with the new. Design Brooklyn is sure to resonate far beyond its borders.\" -Ingrid Abramovitch, Author of Restoring a House in the City \"A visual feast of the best of Brooklyn style.\" -atHome magazine \"Packed with engaging back stories of Brooklyn's homes, shops, restaurants and public institutions like Fort Greene Park and the Brooklyn Botanic Garden Visitor Center in Prospect Heights.\" -New York Times \"It's turned the borough into a playground for high design, all beautifully chronicled in a new survey by Anne Hellman, Design Brooklyn, with page after page of gorgeous photos by Michel Arnaud.\" -Town Country \"Design Brooklyn is expansive, inclusive and filled with inspiring ideas and images of interiors, both public and private.\" -Janel Laban, Apartment Therapy \"What makes this book special, is that it documents the interior spaces of Brooklyn in a way that I haven't seen before. We all know that Brooklyn has drastically changed in the last few years, but it's rare to get the opportunity to peek into some of the private homes or have the luxury of time or money to check out all the new public spaces-restaurants, bars and hotels-that have popped up around the borough . . . It gave me a new appreciation for the sheer volume of design happening in Brooklyn every day.\" -Amy Azzarito, Design*Sponge  \"Quirky, spirited, surprising and useful-brimming with charm and delight.\" -New York Times Book Review  

O presente trabalho tem como objetivo mensurar a eficiência técnica dos municípios da mesorregião do sudeste paraense na utilização dos recursos para prover serviços em saúde. A pesquisa identificou disparidades entre os níveis de eficiência encontrados, tomando como referência os municípios da mesorregião sudeste paraense. O método utilizado foi para medir a eficiência foi a Análise Envoltória de Dados. Como resultados do estudo foi perceptível a discrepância entre o grau de eficiência técnica entre os municípios, sendo que dos 30 municípios que compunham a amostra do estudo, 15 apresentaram um grau de eficiência excelente, 10 municípios obtiveram um grau de eficiência classificado como bom e 5 dos municípios da amostra obtiveram um fraco grau de eficiência. O estudo aponta a necessidade de criação de uma rede institucional de relacionamento onde os gestores possam buscar alternativas de troca de experiências bem sucedidas em municípios próximos ao seu contexto The present study aims to measure the technical efficiency of the municipalities of the southeastern region of the state of Pará in the use of resources to provide health services. The research identified disparities between the levels of efficiency found, taking as reference the municipalities of the southeastern mesoregion of Pará. The method used to measure efficiency was the Data Envelopment Analysis. As results of the study it was noticeable the discrepancy between the degree of technical efficiency among the municipalities, being that of the 30 municipalities that comprised the sample of the study, 15 municipalities presented an excellent degree of efficiency, 10 municipalities obtained a degree of efficiency classified as good and 5 of the municipalities of the sample obtained a weak degree of efficiency. The study points out the need to create an institutional relationship network where managers can seek alternatives to exchange successful experiences in municipalities close to their context

Young forming stars host circumstellar disks of dust and gas. High-resolution, millimeter observations of disks at the protoplanetary stage reveal substructures such as gaps, rings, arcs, spirals, and cavities. These structures are often attributed to disturbances from young, newly formed planets or mechanisms conducive to planet formation. However, the formation mechanisms of the substructures are unconstrained, and only a few disks at the younger protostellar stage have known substructures to date. In this thesis, we present a detailed analysis of 1.3 and 0.87 mm observations of ten protostellar disks in the Ophiuchus star-forming region in a search for the origins of the substructure. Of the sample of ten, four disks have identified structure, three are smooth disks, and three are ambiguous. The structured disks have wide Gaussian-like rings (σR/Rdisk ∼ 0.26) above a smooth disk profile with low contrasts (C < 0.2) in comparison to protoplanetary disks where the rings are narrow and have a wide variety of contrasts (σR/Rdisk ∼ 0.08 and C ranges from 0 − 1). These structured protostellar disks are the brightest sources in the Ophiuchus sample, in agreement with trends observed for protoplanetary disks, and two show evidence of flaring, indicating large dust grains have not had time to fully settle onto the midplane of the disk. These observations indicate that structure in protostellar disks may be common. The presence of structure at the earliest stages suggests an early start for dust grain growth and, subsequently planet formation.

No regime federativo, a distribuição de receitas entre as esferas de governos ocorre com o intuito de sanar as desigualdades inter e intrarregionais. Diante do exposto, considerando a baixa arrecadação das receitas próprias e a nítida necessidade da maioria dos municípios de pequeno e médio porte na região norte do Brasil em relação as transferências governamentais para o financiamento de suas atividades, levanta-se o seguinte problema: qual o nível de dependência dos municípios do Estado do Pará e suas mesorregiões em relação aos repasses intergovernamentais e quanto é a representatividade em relação as suas receitas próprias? O objetivo geral deste trabalho tem como critério norteador analisar a condição e o comportamento das receitas dos municípios paraenses durante os anos de 2010, 2015 e 2020. O objetivo específico é analisar a relação da receita total dos municípios com o nível de dependência das transferências intergovernamentais em relação as suas receitas próprias no período analisado. Em relação aos procedimentos metodológicos a pesquisa caracteriza-se como Qualitativa de caráter descritivo devido ao alinhamento dos objetivos serem voltados a coletar observar, analisar, comparar e interpretar os dados obtidos dos municípios escolhidos para acompanhar a evolução da composição das receitas arrecadadas pelas administrações municipais. Os municípios com os menores IDH-Ms são altamente dependentes dos recursos financeiros providos por outras esferas de governo, o que sugere a necessidade de políticas públicas que possam promover o desenvolvimento local e reduzir essa dependência. Embora tenham ocorrido variações no fluxo orçamentário ao longo dos anos, a dependência dos municípios em relação às transferências intergovernamentais continua alta, sendo a principal fonte de recursos para a maioria deles