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"Dalrymple, William"
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Clinical and cognitive features associated with psychosis in Parkinson's disease: a longitudinal study
Parkinson's disease psychosis (PDPsy) is associated with increased nursing home placement and mortality and is closely linked with cognitive dysfunction.
Assess the clinical and cognitive features associated with PDPsy in patients without dementia.
We prospectively recruited people with Parkinson's disease (PwP) without dementia for a 3-year, longitudinal study at an outpatient movement disorders clinic. Participants completed annual visits involving assessment of motor and non-motor symptoms including neuropsychological testing. PDPsy was defined as the recurring presence of visual illusions, sense of presence, hallucinations, or delusions for at least 1 month. Using generalized estimating equations, we conducted two sets of analyses to separately assess the clinical and the cognitive predictors of PDPsy.
We enrolled 105 participants. At baseline, mean age was 67.8 (SD = 8.0), median disease duration was 4.9 years (IQR: 3.4-7.7), and mean MoCA was 24.8 (SD = 2.3). Prevalence of PDPsy increased over 3 years from 31% (
= 32) to 39% (
= 26). Forty-five participants (43%) experienced PDPsy. Visual illusions were most common (70%,
= 84), followed by hallucinations (58.3%,
= 70). In multivariate analysis, of the clinical variables, only depressive symptoms [OR 1.09, 95% CI: (1.03, 1.16),
= 0.004] increased the odds of PDPsy; of the cognitive variables, only Trail Making Test B-A scores [OR 1.43, 95% CI: (1.06, 1.93),
= 0.018] significantly increased the odds of PDPsy.
In PwP without dementia, depressive symptoms were associated with increased risk of PDPsy. Executive/attentional dysfunction was also associated with PDPsy and may mark the transition from isolated minor hallucinations to more complex psychotic symptoms.
Journal Article
The age of Kali : Indian travels & encounters
As he searched for evidence of Kali Yug, the \"age of darkness\" predicted by an ancient Hindu cosmology in a final epoch of strife and corruption, Dalrymple encountered a region that thrilled and surprised him. Venturing to places rarely visited by foreigners, he presents compelling portraits of a diverse range of figures. His love for the subcontinent comes across in every page, which makes its chronicles of political corruption, ethnic violence and social disintegration all the more poignant. The result is a dark yet vibrant travelogue, and a unique look at a region that continues to be marked by rapid change and unlimited possibilities as it struggles to reconcile the forces of modernity and tradition.
Book
La anarquía
En 1765, la Compañía de las Indias Orientales derrocó al joven emperador mogol y puso en su lugar un gobierno controlado por mercaderes ingleses que extorsionaba impuestos merced a su ejército privado. Fue este el momento que señaló la transformación de la Compañía de las Indias Orientales en algo muy distinto a una empresa: una corporación internacional pasó a ser un agresivo poder colonial. Durante el siguiente medio siglo, la Compañía continuó extendiendo su poder hasta que prácticamente toda la India al sur de Delhi era controlada desde un despacho londinense.
William Dalrymple, autor del aclamado El retorno de un rey, cuenta en La anarquía. La Compañía de las Indias orientales y el expolio de la India cómo el Imperio mogol, que había dominado el comercio y la manufactura mundiales, y que poseía recursos casi ilimitados, se derrumbó y fue reemplazado por una corporación multinacional enclavada a miles de kilómetros al otro lado del mundo.
Una corporación que respondía a unos accionistas que jamás habían estado en la India y que no tenían la menor idea del país cuya riqueza les reportaba jugosos dividendos. A partir de fuentes inéditas, Dalrymple narra la historia de la Compañía de las Indias Orientales como nunca se ha hecho: una historia sobre los devastadores resultados que puede tener el abuso de poder por parte de una gran corporación, y que resuena amenazadoramente familiar en nuestro siglo XXI de todopoderosas empresas transnacionales.
eBook
BRITISH CHILDREN MUST BE TAUGHT IMPERIAL HISTORY
While it makes sense for politicians to apologise for their own mistakes, it is surely pointless for them to apologise for the mistakes of others committed long before they were born. What British prime minister David Cameron can do, however, if he feels real contrition for Britain's past, is to make the teaching of the British empire a compulsory part of the history syllabus in schools across the UK. Most British people are by and large completely unaware of the details of their imperial history. For people must never forget that whatever its achievements, the British empire was both gained and maintained by military might, and built over a mountain of skulls of those it conquered and defeated.
Journal Article
