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هذه هي الصين : قوة تسير نحو العالم
يركز كتاب \"هذه هي الصين\" على سرد قصص تنمية الصين في العصر الجديد. وقد غير الدكتور تشانغ وي وي طريقته المعروفة بالتوجيه والإرشاد في البرامج الأيديولوجية والنظرية في الماضي، وعبر عنها بلغة شعبية سائغة، وحجج منطقية صارمة، وبيانات حقيقية، وتصادمات صريحة للأفكار، وتقنيات عرض مبتكرة لمساعدة الجمهور على فهم النموذج الصيني والطريق الصيني، وتعزيز ثقتهم بمستقبل الصين.
Book
Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population： Results from a Nationally Representative Survey
Background： Nontraumatic osteonecrosis of the femoral head （NONFH） is a debilitating disease that represents a significant financial burden for both individuals and healthcare systems. Despite its significance, however, its prevalence in the Chinese general population remains unknown. This study aimed to investigate the prevalence of NONFH and its associated risk factors in the Chinese population. Methods： A nationally representative survey of 30,030 respondents was undertaken from June 2012 to August 2013. All participants underwent a questionnaire investigation, physical examination of hip, and bilateral hip joint X-ray and/or magnetic resonance imaging exalnination. Blood samples were taken after overnight fasting to test serum total cholesterol, triglyceride, and high-density lipoprotein （HDL） and low-density lipoprotein （LDL） levels. We then used multivariate logistic regression analysis to investigate the associations between various metabolic, demographic, and lifestyle-related variables and NONFH. Results： NONFH was diagnosed in 218 subjects （0.725%） and the estimated NONFH cases were 8.12 million among Chinesepeople aged 15 years and over. The prevalence of NONFH was significantly higher in males than in females （1.02% vs. 0.51%, x^2 = 24.997, P 〈 0.001 ）. Among NONFH patients, North residents were subjected to higher prevalence of NONFH than that of South residents （0.85% vs. 0.61%,x^2= 5.847, P = 0.016）. Our multivariate regression analysis showed that high blood levels oftriglycerides, total cholesterol, LDL-cholesterol, and non-H DL-cholesterol, male, urban residence, family history of osteonecrosis of the femoral head. heavy smoking, alcohol abuse and glucocorticoid intake, overweight, and obesity were all significantly associated with an increased risk of NONFH. Conclusions： Our findings highlight that NONFH is a significantpublic health challenge in China and underscore the need for policy measures on the national level. Furthermore, NONFH shares a number of risk factors with atherosclerosis.
Journal Article
من أجلك مستقبلا : رسالة إلى ابنتي /
يطرح هذا الكتاب رسائل في مجال علم النفس التربوي تقدمها لنا الأديبة الصينية يان جيان لينغ عن طبيعة الفتاة وكيفية التعامل معها والطرق السليمة للتربية وذلك من خلال مواقف حياتية حقيقية تسردها بأسلوب أدبي شيق، ويعد ذلك الكتاب مفتاح الدخول إلى عالم الفتاة، لذا فهو مفيد لكل الآباء والأمهات في التعرف على طرق التربية الصحيحة.
Book
من أجلك مستقبلا : رسالة إلى ابنتي
يطرح هذا الكتاب رسائل في مجال علم النفس التربوي تقدمها لنا الأديبة الصينية يان جيان لينغ عن طبيعة الفتاة وكيفية التعامل معها والطرق السليمة للتربية وذلك من خلال مواقف حياتية حقيقية تسردها بأسلوب أدبي شيق، ويعد ذلك الكتاب مفتاح الدخول إلى عالم الفتاة، لذا فهو مفيد لكل الآباء والأمهات في التعرف على طرق التربية الصحيحة.
Book
Deep learning-based high-accuracy quantitation for lumbar intervertebral disc degeneration from MRI
To help doctors and patients evaluate lumbar intervertebral disc degeneration (IVDD) accurately and efficiently, we propose a segmentation network and a quantitation method for IVDD from T2MRI. A semantic segmentation network (BianqueNet) composed of three innovative modules achieves high-precision segmentation of IVDD-related regions. A quantitative method is used to calculate the signal intensity and geometric features of IVDD. Manual measurements have excellent agreement with automatic calculations, but the latter have better repeatability and efficiency. We investigate the relationship between IVDD parameters and demographic information (age, gender, position and IVDD grade) in a large population. Considering these parameters present strong correlation with IVDD grade, we establish a quantitative criterion for IVDD. This fully automated quantitation system for IVDD may provide more precise information for clinical practice, clinical trials, and mechanism investigation. It also would increase the number of patients that can be monitored.
Globally, as a major public health problem, low back pain has been the leading cause of disability worldwide for the past 30 years. Here, the authors propose a segmentation network and a quantitative method lumbar intervertebral disc degeneration assessment.
Journal Article
قصة نجاح \علي بابا\ : حياة \جاك ما\ أغني رجل في الصين
طفل صغير لعائلة فقيرة تهوى التمثيل، طالب فاشل يتعلم الإنجليزية، مدرس متوسط المستوى، سائق عربة بضائع، عاطل عن العمل، يفشل في الالتحاق بأي وظيفة، مترجم لغة إنجليزية محترف، صاحب شركة ترجمة، صاحب موقع إلكتروني لجمع البيانات، مؤسس أكبر موقع متخصص في التجارة بين الشركات، صاحب مؤسسة \"علي بابا\" أكبر رجل أعمال في الصين، أغنى أغنياء الصين، كل هؤلاء في الحقيقة هم شخص واحد، أو بمعنى أصح هي قصة حياة أسطورة الصين حالياً، الرجل الذي غير خريطة التجارة العالمية، إنه \"ما يون\" حسب الاسم الصيني أو جاك ما حسب ما هو معروف به في العالم، والذي يحكي كتاب \"قصة نجاح علي بابا\"، قصة صعوده والتي هي أيضا قصة صعود الصين. يقترب المؤلف من عالم \"جاك ما\" الحقيقي ويحكي قصته منذ نعومة أظفاره، حتى صار إمبراطور التجارة في العالم، إنها قصة صعود شخص وصعود دولة بحجم الصين، قصة ترفض أن يكون هناك مستحيل، وتثبت أن الأفكار هي رأس المال الأكبر في العالم، قصة الفضائي كما يجب أن يسميه الصينيون، الذي جعل حياتهم أفضل، قصة رجل حفر اسمه في تاريخ البشرية، والذي يفتح لنا بتجربته آفاقا أرحب نرى بها العالم ونرى بها أنفسنا بشكل مختلف.
Book
A multi-classifier system integrated by clinico-histology-genomic analysis for predicting recurrence of papillary renal cell carcinoma
Integrating genomics and histology for cancer prognosis demonstrates promise. Here, we develop a multi-classifier system integrating a lncRNA-based classifier, a deep learning whole-slide-image-based classifier, and a clinicopathological classifier to accurately predict post-surgery localized (stage I–III) papillary renal cell carcinoma (pRCC) recurrence. The multi-classifier system demonstrates significantly higher predictive accuracy for recurrence-free survival (RFS) compared to the three single classifiers alone in the training set and in both validation sets (C-index 0.831-0.858 vs. 0.642-0.777, p < 0.05). The RFS in our multi-classifier-defined high-risk stage I/II and grade 1/2 groups is significantly worse than in the low-risk stage III and grade 3/4 groups (p < 0.05). Our multi-classifier system is a practical and reliable predictor for recurrence of localized pRCC after surgery that can be used with the current staging system to more accurately predict disease course and inform strategies for individualized adjuvant therapy.
Renal cell carcinoma consists of several subtypes, and recurrence is highly dependent on subtype. Here, the authors develop a multi-classifier using imaging, lncRNA and clinical data to predict recurrence in papillary renal cell carcinoma.
Journal Article
Genome-wide association study identifies novel susceptible loci and evaluation of polygenic risk score for chronic obstructive pulmonary disease in a Taiwanese population
Background
Chronic Obstructive Pulmonary Disease (COPD) describes a group of progressive lung diseases causing breathing difficulties. While COPD development typically involves a complex interplay between genetic and environmental factors, genetics play a role in disease susceptibility. This study used genome-wide association studies (GWAS) and polygenic risk score (PRS) to elucidate the genetic basis for COPD in Taiwanese patients.
Results
GWAS was performed on a Taiwanese COPD case–control cohort with a sample size of 5,442 cases and 17,681 controls. Additionally, the PRS was calculated and assessed in our target groups. GWAS results indicate that although there were no single nucleotide polymorphisms (SNPs) of genome-wide significance, prominent COPD susceptibility loci on or nearby genes such as
WWTR1
,
EXT1
,
INTU
,
MAP3K7CL
,
MAMDC2
,
BZW1/CLK1
,
LINC01197
,
LINC01894
, and
CFAP95
(
C9orf135
) were identified, which had not been reported in previous studies. Thirteen susceptibility loci, such as
CHRNA4
,
AFAP1
, and
DTWD1
, previously reported in other populations were replicated and confirmed to be associated with COPD in Taiwanese populations. The PRS was determined in the target groups using the summary statistics from our base group, yielding an effective association with COPD (odds ratio [OR] 1.09, 95% confidence interval [CI] 1.02–1.17,
p
= 0.011). Furthermore, replication a previous lung function trait PRS model in our target group, showed a significant association of COPD susceptibility with PRS of Forced Expiratory Volume in one second (FEV
1
)/Forced Vital Capacity (FCV) (OR 0.89, 95% CI 0.83–0.95,
p
= 0.001).
Conclusions
Novel COPD-related genes were identified in the studied Taiwanese population. The PRS model, based on COPD or lung function traits, enables disease risk estimation and enhances prediction before suffering. These results offer new perspectives on the genetics of COPD and serve as a basis for future research.
Journal Article