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"Galen"
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Field-Evolved Resistance in Corn Earworm to Cry Proteins Expressed by Transgenic Sweet Corn
Transgenic corn engineered with genes expressing insecticidal toxins from the bacterium Bacillus thuringiensis (Berliner) (Bt) are now a major tool in insect pest management. With its widespread use, insect resistance is a major threat to the sustainability of the Bt transgenic technology. For all Bt corn expressing Cry toxins, the high dose requirement for resistance management is not achieved for corn earworm, Helicoverpa zea (Boddie), which is more tolerant to the Bt toxins.
We present field monitoring data using Cry1Ab (1996-2016) and Cry1A.105+Cry2Ab2 (2010-2016) expressing sweet corn hybrids as in-field screens to measure changes in field efficacy and Cry toxin susceptibility to H. zea. Larvae successfully damaged an increasing proportion of ears, consumed more kernel area, and reached later developmental stages (4th - 6th instars) in both types of Bt hybrids (Cry1Ab-event Bt11, and Cry1A.105+Cry2Ab2-event MON89034) since their commercial introduction. Yearly patterns of H. zea population abundance were unrelated to reductions in control efficacy. There was no evidence of field efficacy or tissue toxicity differences among different Cry1Ab hybrids that could contribute to the decline in control efficacy. Supportive data from laboratory bioassays demonstrate significant differences in weight gain and fitness characteristics between the Maryland H. zea strain and a susceptible strain. In bioassays with Cry1Ab expressing green leaf tissue, Maryland H. zea strain gained more weight than the susceptible strain at all concentrations tested. Fitness of the Maryland H. zea strain was significantly lower than that of the susceptible strain as indicated by lower hatch rate, longer time to adult eclosion, lower pupal weight, and reduced survival to adulthood.
After ruling out possible contributing factors, the rapid change in field efficacy in recent years and decreased susceptibility of H. zea to Bt sweet corn provide strong evidence of field-evolved resistance in H. zea populations to multiple Cry toxins. The high adoption rate of Bt field corn and cotton, along with the moderate dose expression of Cry1Ab and related Cry toxins in these crops, and decreasing refuge compliance probably contributed to the evolution of resistance. Our results have important implications for resistance monitoring, refuge requirements and other regulatory policies, cross-resistance issues, and the sustainability of the pyramided Bt technology.
Journal Article
Vertical eddy iron fluxes support primary production in the open Southern Ocean
The primary productivity of the Southern Ocean ecosystem is limited by iron availability. Away from benthic and aeolian sources, iron reaches phytoplankton primarily when iron-rich subsurface waters enter the euphotic zone. Here, eddy-resolving physical/biogeochemical simulations of a seasonally-forced, open-Southern-Ocean ecosystem reveal that mesoscale and submesoscale isopycnal stirring effects a cross-mixed-layer-base transport of iron that sustains primary productivity. The eddy-driven iron supply and consequently productivity increase with model resolution. We show the eddy flux can be represented by specific well-tuned eddy parametrizations. Since eddy mixing rates are sensitive to wind forcing and large-scale hydrographic changes, these findings suggest a new mechanism for modulating the Southern Ocean biological pump on climate timescales.
The Southern Ocean is an important sink of carbon via the biological pump. Here authors run high-resolution physical/biogeochemical simulations of an open-Southern Ocean ecosystem forced with a realistic seasonal cycle and confirm that (sub)mesoscale iron transport across the mixing-layer base sustains primary productivity.
Journal Article
Hygiene
\"Galen of Pergamum (AD 129-?199/216), physician to the court of the emperor Marcus Aurelius, was a philosopher, scientist, medical historian, theoretician, and practitioner who wrote forcefully and prolifically on an astonishing range of subjects and whose impact on later eras rivaled that of Aristotle. Galen synthesized the entirety of Greek medicine as a basis for his own doctrines and practice, which comprehensively embraced theory, practical knowledge, experiment, logic, and a deep understanding of human life and society. His treatise Hygiene, also known as \"On the Preservation of Health\" (De sanitate tuenda), was written during one of Galen's most prolific periods (170-180) and ranks among his most important and influential works, providing a comprehensive account of the practice of preventive medicine that still has relevance today. Also included in this two-volume edition are two shorter treatises on the relationship between health and wellness. Thrasybulus explores the theoretical question of whether hygiene is part of medicine or gymnastics, and in so doing delineates the interrelated roles of doctors and physical therapists. On Exercise with a Small Ball strenuously advocates that activity's superiority to all other forms of exercise.\"-- Provided by publisher.
BOOK
Delayed Recognition of Deterioration of Patients in General Wards Is Mostly Caused by Human Related Monitoring Failures: A Root Cause Analysis of Unplanned ICU Admissions
An unplanned ICU admission of an inpatient is a serious adverse event (SAE). So far, no in depth-study has been performed to systematically analyse the root causes of unplanned ICU-admissions. The primary aim of this study was to identify the healthcare worker-, organisational-, technical,- disease- and patient- related causes that contribute to acute unplanned ICU admissions from general wards using a Root-Cause Analysis Tool called PRISMA-medical. Although a Track and Trigger System (MEWS) was introduced in our hospital a few years ago, it was implemented without a clear protocol. Therefore, the secondary aim was to assess the adherence to a Track and Trigger system to identify deterioration on general hospital wards in patients eventually transferred to the ICU.
Retrospective observational study in 49 consecutive adult patients acutely admitted to the Intensive Care Unit from a general nursing ward. 1. PRISMA-analysis on root causes of unplanned ICU admissions 2. Assessment of protocol adherence to the early warning score system.
Out of 49 cases, 156 root causes were identified. The most frequent root causes were healthcare worker related (46%), which were mainly failures in monitoring the patient. They were followed by disease-related (45%), patient-related causes (7, 5%), and organisational root causes (3%). In only 40% of the patients vital parameters were monitored as was instructed by the doctor. 477 vital parameter sets were found in the 48 hours before ICU admission, in only 1% a correct MEWS was explicitly documented in the record.
This in-depth analysis demonstrates that almost half of the unplanned ICU admissions from the general ward had healthcare worker related root causes, mostly due to monitoring failures in clinically deteriorating patients. In order to reduce unplanned ICU admissions, improving the monitoring of patients is therefore warranted.
Journal Article
Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD
Although culture-independent techniques have shown that the lungs are not sterile, little is known about the lung microbiome in chronic obstructive pulmonary disease (COPD). We used pyrosequencing of 16S amplicons to analyze the lung microbiome in two ways: first, using bronchoalveolar lavage (BAL) to sample the distal bronchi and air-spaces; and second, by examining multiple discrete tissue sites in the lungs of six subjects removed at the time of transplantation. We performed BAL on three never-smokers (NS) with normal spirometry, seven smokers with normal spirometry (\"healthy smokers\", HS), and four subjects with COPD (CS). Bacterial 16 s sequences were found in all subjects, without significant quantitative differences between groups. Both taxonomy-based and taxonomy-independent approaches disclosed heterogeneity in the bacterial communities between HS subjects that was similar to that seen in healthy NS and two mild COPD patients. The moderate and severe COPD patients had very limited community diversity, which was also noted in 28% of the healthy subjects. Both approaches revealed extensive membership overlap between the bacterial communities of the three study groups. No genera were common within a group but unique across groups. Our data suggests the existence of a core pulmonary bacterial microbiome that includes Pseudomonas, Streptococcus, Prevotella, Fusobacterium, Haemophilus, Veillonella, and Porphyromonas. Most strikingly, there were significant micro-anatomic differences in bacterial communities within the same lung of subjects with advanced COPD. These studies are further demonstration of the pulmonary microbiome and highlight global and micro-anatomic changes in these bacterial communities in severe COPD patients.
Journal Article
Mindfulness for borderline personality disorder : relieve your suffering using the core skill of dialectical behavior therapy
\"Written by Blaise Aguirre--a prominent psychiatrist specializing in the treatment of borderline personality disorder (BPD)--Mindfulness for Borderline Personality Disorder offers a new, mindfulness-based approach to emotion regulation and the common symptoms associated with BPD. The mindfulness treatments outlined in this book are based on the author's highly successful program at Harvard-affiliated McLean Hospital, and are drawn from dialectical behavioral therapy (DBT), a proven-effective treatment for BPD\"-- Provided by publisher.
Book
Making Mountain Places into State Spaces: Infrastructure, Consumption, and Territorial Practice in a Himalayan Borderland
This article looks at a trans-Himalayan borderland to see how new road development projects affect social and sovereign relationships across mountain landscapes between Chinese Tibet and Mustang, Nepal. Research asked about local experiences with new forms of motorized transport and popular consumption of Chinese-manufactured commodities to understand what factors led the Nepali state to undertake new bureaucratic projects in a historically peripheral space. Employing a dialectic framework of mobility and containment, a materialist-territorial analysis reveals how transborder infrastructure development affects trade relations and consumption practices in the Nepal-China borderlands and, in turn, how these dynamics condition state-making processes at social and geopolitical levels. Following the cross-scalar trajectory of one rural road project from local grassroots initiative to national development program to international transportation network, I argue that the economic interests of a place-based project with regional cultural connections set in motion an expanding presence of Nepali state apparatuses in a trans-Himalayan borderland space.
Journal Article