Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
12
result(s) for
"Gerber, Carole"
Sort by:
Annie Jump Cannon, astronomer
This book depicts the achievements of a woman who developed an important system of classifying stars. To this day, Annie Jump Cannon holds the record for identifying more stars than anyone else in the world. In 1925, she became a professor of astronomy at Harvard and the first woman to receive a doctor of science degree from Oxford University.
Book
How do nurses belonging to the LGBTIQ + community relate to patients? a qualitative study from Switzerland
Background
The relationship between nurses and patients is particularly important, as nursing activities often require a high degree of intimacy. To promote an open, honest, reciprocal and equal relationship, nurses disclose personal information and experiences about themselves. Nurses belonging to the LGBTIQ + community, however, may fear stigmatisation or rejection from their patients if they disclose their sexual orientation or gender identity. This study aims to explore how nurses belonging to the LGBTIQ + community navigate their relationship with patients under these circumstances.
Methods
A qualitative descriptive approach with semi-structured interviews was applied.
Results
Interviews with eight nurses who identified themselves as members of the LGBTIQ + community, were conducted. When building relationships, nurses belonging to the LGBTIQ + community often experience a dilemma as to whether they want to come out to a patient in a care situation/encounter. When patient-carer relationships are being built, there is often a heightened focus on striking a balance between not revealing too much or too little information about themselves.
Conclusions
In everyday life, nurses belonging to the LGBTIQ + community often face the dilemma of a desire for authenticity and the fear of rejection. Disclosing personal information and experiences, (to the right degree), can help build relationships.
Journal Article
A band of babies
When Benny arrives at day care, where the babies are bored, he finds the instruments and soon they are off on a musical journey to the store for a snack.
Book
SUNFISH Part 2: 24-month efficacy and safety of risdiplam in Type 2/3 SMA
SUNFISH (NCT02908685) is a multicentre, two-part, randomised (2:1, risdiplam:placebo), placebo-con- trolled, double-blind study in individuals with Type 2/3 spinal muscular atrophy (SMA; inclusion criteria 2–25 years at enrolment). SUNFISH investigates efficacy and safety of risdiplam, a centrally and periph- erally distributed oral survival of motor neuron 2 pre-mRNA splicing modifier. Risdiplam (EVRYSDI™) has been approved by the US Food and Drug Administration for the treatment of individuals with SMA, aged 2 months and older.In Part 1 (N=51) the safety, tolerability and pharmacokinetics/pharmacodynamics of different risdiplam dose levels were assessed. Part 2 (N=180) assessed the efficacy and safety of the Part 1-selected dose of risdiplam versus placebo in Type 2 and non-ambulant Type 3 SMA. Individuals received risdiplam or placebo for 12 months; all individuals then received risdiplam until Month 24, when they had the oppor- tunity to enter the open-label extension phase.In Part 2, the primary outcome of the study was met, showing a statistically significant difference in change from baseline in 32-item Motor Function Measure total score at Month 12 between individuals treated with risdiplam (n=120) and placebo (n=60). No treatment-related safety findings leading to withdrawal were reported. Here we present SUNFISH Part 2 data after 24 months’ treatment.g.baranello@ucl.ac.uk16
Journal Article
Leaf jumpers
Illustrations and rhyming text describe different leaves and the trees from which they fall.
Book
Cellular adaptive immune response against porcine circovirus type 2 in subclinically infected pigs
Background
Porcine circovirus type 2 (PCV2) is a dominant causative agent of postweaning multisystemic wasting syndrome (PMWS), a multifactorial disease complex with putative immunosuppressive characteristics. Little is known about adaptive PCV2-specific immune responses in infected pigs. Therefore, the T and B cell responses following PCV2 infection in 3-week old SPF piglets infected with PCV2 or PCV2 plus porcine parvovirus (PPV) were studied.
Results
All animals were asymptomatically infected. At 7 days post infection (d p.i.), B lymphocyte and T lymphocyte numbers decreased in the dual infected, but not in the single infected piglets. At this time point a transient PCV2 viraemia was noted in the PCV2 infected groups. Antibodies against the infecting virus were detectable at day 24-28 p.i. for anti-PCV2 antibodies and at day 10 p.i. for anti-PPV antibodies, with no apparent influence of PCV2 on the early PPV antibody development. In the animals infected with PPV alone, IFN-γ secreting cells (SC) that were not specific for PCV2 were detected by ELISPOT assay at day 7 p.i. Interestingly, this response was absent in the PCV2/PPV dual infected animals. PCV2-specific IFN-γ SC were observed in the PCV2/PPV infected group at 7 d p.i. and in the PCV2 single infected group at 21 d p.i. A reduction in the numbers of IFN-γ SC was observed following anti-CD4 and anti-CD8 antibody treatment, suggesting roles for both CD4
+
and CD8
+
T cells in the response against PCV2 infection. This was supported by an observed increase in the percentage of IFN-γ positive CD8
hi
cytotoxic T cells as well as IFN-γ positive CD8
-/low
helper T cells after PCV2
in vitro
re-stimulation.
Conclusions
Infection of weaned SPF piglets with PCV2 alone or combined with PPV does not induce disease and in both cases a relatively slow anti-PCV2 antibody response and weak T lymphocyte responses were found. Knowledge on such immunological characteristics is important for both PCV2 pathogenesis and vaccination.
Journal Article
The impact of frozen sections on final surgical margins in squamous cell carcinoma of the oral cavity and lips: a retrospective analysis over an 11 years period
Background
Taking intraoperative frozen sections (FS) is a widely used procedure in oncologic surgery. However so far no evidence of an association of FS analysis and premalignant changes in the surgical margin exists. Therefore, the aim of this study was to evaluate the impact of FS on different categories of the final margins of squamous cell carcinoma (SCC) of the oral cavity and lips.
Methods
FS, pT-stage, grading, and tumor localization of 178 patients with SCC of the oral cavity and lips were compared by uni- and multivariate analysis in patients with positive, dysplastic and negative surgical margin status.
Results
Performed on 111 patients (62.4%), intraoperative FS did not have any statistically significant influence on final margin status, independent of whether it was positive (p = 0.40), dysplastic (p = 0.70), or negative (p = 0.70). Positive surgical margins in permanent sections were significantly associated with pT4-tumors (OR 5.61, p = 0.001). The chance for negative margins in permanent sections was significantly higher in tumors located in the tongue (OR 4.70, p = 0.01).
Conclusions
Our data suggests that intraoperative FS in SCC can be useful in selected cases. However it is not advisable as a routine approach.
Journal Article