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To improve the informatization and intelligence level of high-speed railway (HSR) bridge construction, a parametric modeling method for continuous beam bridges based on Building Information Modeling (BIM) is proposed in this study. By this method, the parametric families of continuous beam components and key construction machinery are established, and the rapid modeling of overall continuous beam bridge and the simulation of critical construction process are realized as well. Taking the Caoxian-Shangqiu bridge of Xiong’an-Shangqiu HSR as a case study, the parametric modeling method is applied to conduct the engineering application on the prestressed duct layout and rebar clash detection. The results indicate that the modeling efficiencies of HSR continuous beam bridge and construction machinery are significantly increased by the established parametric modeling method. Based on the BIM model of continuous beam bridge, the improvement in the precision of prestressed duct layout and the elimination of rebar clash points can be achieved. The research achievement can guide the visualization of construction disclosure, enhance construction efficiency, and provide reference and technical support for the construction management and control of HSR continuous beam bridges.

Objective TIGIT/CD155 has attracted widespread attention as a new immune checkpoint and a potential target for cancer immunotherapy. In our study, we evaluated the role of TIGIT/CD155 checkpoints in the progression of cervical cancer. Methods The expression of CD155 and TIGIT in cervical cancer tissues was detected using flow cytometry, immunohistochemistry (IHC) and gene expression profiling. In vivo and in vitro experiments have proven that blocking TIGIT/CD155 restores the ability of CD8 + T cells to produce cytokines. Changes in the NF-κB and ERK pathways were detected using western blotting (WB) after blocking TIGIT/CD155 signalling. Results TIGIT expression was elevated in patients with cervical cancer. High TIGIT expression in CD8 + T lymphocytes from patients with cervical cancer promotes the exhaustion of CD8 + T lymphocytes. In addition, CD155 is expressed at high levels in cervical cancer tissues and is negatively correlated with the level of infiltrating CD8 + T cells. We found that TIGIT, upon binding to CD155 and being phosphorylated, inhibited NF-κB and ERK activation by recruiting SHIP-1, resulting in the downregulation of cytokine production. Blocking TIGIT in activated CD8 + T cells attenuates the inhibitory effect of SHIP-1 on CD8 + T cells and enhances the activation of NF-κB and ERK. In vivo and in vitro experiments have proven that blocking TIGIT/CD155 restores the ability of CD8 + T cells to produce cytokines. Injecting the blocking antibody TIGIT in vivo inhibits tumour growth and enhances CD8 + T lymphocyte function. Treatment with a combination of TIGIT and PD-1 inhibitors further increases the efficacy of the TIGIT blocking antibody. Conclusions Our research shows that TIGIT/CD155 is a potential therapeutic target for cervical cancer.

In this study, the two influence systems in a snowstorm that occurred in January 2021 are analyzed using conventional observation, intensive snowfall observation data and NCEP-FNL 0.25°×0.25° analysis data. The results show that, first, the westerly trough combined with the surface convergence line and the sub cold front produces strong snowfall in the southern part of the Liaodong Peninsula, then the strong cold air moves southward into the cold flow snowfall. When the westerly trough system has a large water vapor flux, deep wet layer and strong ascending motion, the surface is accompanied by the obvious warm tongue in southwest Dalian and cold pad in the inland, and there is obvious frontogenesis process, with heavy snowfall. The intensity of cold advection is closely related to the amount of snowfall: the stronger the cold advections, the greater the snowfall will be. The combination of mid-upper-level divergence with negative vorticity and convergence with positive vorticity near the ground is also an advantage for heavy snowfall. Cold flow snowfall exhibits strong local characteristics. Compared with the westerly trough system, the cold flow snowfall has a smaller influence area and intensity. The combination of strong ascending motion and wet area is also one of the focuses of cold flow snowfall forecast in Dalian.

Over the past decade, time-domain astronomy in optical bands has developed rapidly with the operations of some wide-field survey facilities. However, most of these surveys are conducted with only a single band, and simultaneous color information is usually unavailable for the objects monitored during the survey. Here we present introductions to the system of Tsinghua University-Ma Huateng Telescopes for Survey (TMTS), which consists of an array of four optical telescopes installed on a single equatorial mount. Such a system is designed to get multiband photometry simultaneously for stars and transients discovered during the survey. The optics of each telescope is a modified Hamilton-Newtonian system, covering the wavelengths from 400 to 900 nm, with a field of view (FoV) of about 4.5 deg2 and a plate scale of 1 86 pixel−1 when combining with a 4K × 4K QHY4040 CMOS detector. The TMTS system can have a FoV of about 9 deg2 when monitoring the sky with two bands (i.e., SDSS g and r filters) at the same time, and a maximum FoV of ∼18 deg2 when four telescopes monitor different sky areas in monochromatic filter mode. For an exposure time of 60 s, the average 3 detection limit of the TMTS system can reach at ∼19.4 mag in Luminous filter and at ∼18.7 mag in SDSS r filter. The preliminary discovery obtained during the first few months' survey is briefly discussed. As this telescope array is located at the Xinglong Observatory of NAOC, it can have an excellent synergy with the spectroscopic survey by the LAMOST (with a FoV of about 20 deg2) at the same site, which will benefit the studies of stellar and binary physics besides the transient sciences.

A large-scale persistent fog event occurred over the Yellow Sea of China from April 27 to May 4, 2015. In this study, we used satellite remote sensing data, ground meteorological observed data, global sounding data, and reanalysis data from the National Centers for Environmental Prediction (NCEP) and sea surface temperature (SST) data from the National Oceanic and Atmospheric Administration (NOAA) to analyze the evolutionary characteristics, the boundary-layer marine meteorological characteristics, and the development mechanism of the sea fog event. The results show that the sea fog event was a warm advective fog process. The Yellow Sea was at the rear of the warm high and the front of the continental low (circulation situation with high in the east and low in the west). The southerly and southeasterly winds transported warm and moist air from the Northwest Pacific northward to the Yellow Sea which served as the water vapor source. A thermal turbulence interface was formed during the sea fog development. The weak vertical wind shear below the interface was conducive to the maintenance and development of sea fog in the area of the temperature inversion in the boundary layer and the formation of a certain thickness of sea fog. The sea fog occurred in the area with water vapor convergence, where the 2-m dew point was slightly higher than the SST. The area with a relative humidity greater than 90% and an air–sea temperature difference from 0 to 2 °C overlapped with the sea fog area, and these two values indicate the extent of the sea fog.

To investigate the prognostic role of the platelet‐to‐lymphocyte ratio (PLR) in melanoma through a meta‐analytical method. The literature was searched using the PubMed, Embase, Web of Science, Cochrane Library, and Scopus electronic platforms. Hazard ratios (HRs) for overall survival (OS) and progression‐free survival (PFS) and their corresponding 95% confidence intervals (CIs) were calculated. Begg's test and Egger's test were used to assess potential publication bias. A total of eight retrospective cohort studies involving 2099 patients were included in the meta‐analysis. No significant association between the PLR and OS was found (HR = 1.39; 95% CI = 0.97‐1.99; P = .075). There was also a nonsignificant correlation between the PLR and PFS (HR = 1.49; 95% CI = 0.98‐2.27; P = .065). In addition, there was no significant association between the PLR and sex (odds ratio [OR] = 1.14; 95% CI = 0.23‐5.66; P = .869) or age (OR = 0.81; 95% CI = 0.41‐1.59; P = .539). No significant publication bias was found in this meta‐analysis. The pooled analysis suggests that the PLR may not be a significant prognostic marker in patients with melanoma.

To ensure the high-quality output performance of the five-phase fault-tolerant permanent magnet synchronous motor (FTPMSM) drive system under normal and open-circuit faults and achieve the minimal reconfiguration of the FTPMSM control drive system under various open-circuit faults, in this paper, a fault-tolerant field-oriented control (FOC) strategy based on disturbance adaption is proposed. The speed-loop and current-loop steady-healthy controllers are designed to effectively suppress the torque ripples caused by open-circuit faults and improve the robustness of the drive system to load disturbance and motor parameter variation under fault operation. Moreover, the additional zero-sequence current controller can be omitted. In addition, the modified reduced-order coordinate transformation matrices are proposed to weaken the influence of oscillating neutral. Finally, the fault-tolerant FOC system of the FTPMSM is established, and its experiment is conducted. The experimental results verify the feasibility and effectiveness of the proposed control strategy.

Objective To summarize the clinical diagnosis and treatment of superabsorbent polymer balls as nasal foreign bodies in children. Methods We retrospectively analysed the clinical data concerning 12 cases of superabsorbent polymer balls as nasal foreign bodies in children and summarized the corresponding clinical features, methods of diagnoses and treatment, and prognoses. Results Twelve children with superabsorbent polymer balls as foreign bodies in their nasal cavities presented with relatively severe symptoms, such as congestion, runny nose, and nasal swelling. When such foreign bodies stay in the nasal cavity for a prolonged period, patients may suffer from general discomfort, such as agitation, poor appetite and high fever. Most of the children had to undergo nasal endoscopy under general anaesthesia to have the foreign bodies completely removed. An intraoperative examination revealed significant mucosal injury within the nasal cavity. With regular follow-up visits and adequate interventions, all the patients recovered. Conclusion The longer superabsorbent polymer balls remain in the nasal cavity, the more damaged the nasal mucosa will be. It is challenging to remove such foreign bodies in the outpatient setting. Transnasal endoscopy under general anaesthesia appears to be safer and more effective in such cases. Since the nasal mucosa is injured to varying degrees, postoperative follow-up and treatment are equally important for preventing the occurrence of complications.

Dermatologic diseases are the fourth most frequent nonfatal common illness, yet they have a psychological, economical, and professional burden that is comparable to or larger than other chronic conditions. From a survey in China of 6 provinces, the overall prevalence of psoriasis with squamous cell carcinoma was 0.47%. According to the current investigation, the outburst of skin disease was not associated with gender, but mainly with the climate of the environment; that is, dry cold weather will more likely to induce psoriasis. Approximately 3% of people around the world have psoriasis, which is near the most common autoimmune skin disease in adults. By simple estimation, there are at least two hundred million psoriasis patients in the world. Therefore, it is not just a simple health problem in a country or a region but a serious global challenge. Of note, about half of the adult patients had been reported to be sick in their childhood and they mostly fell ill around 10 years old. Actinic keratosis is perhaps the most common, followed by squamous cell carcinoma and, to a lesser extent, acne vulgaris, psoriasis, and hidradenitis suppurativa, as well as dermatitis herpetiformis. 5-Fluorouracil (5-FU) 0.5 percent is used topically to treat actinic keratosis and squamous cell carcinoma with good outcomes, while it might cause significant toxicity in certain patients. Dapsone, a Valosin-containing protein, is a medication that is often used to treat inflammatory skin disorders like psoriatic arthritis, but it can occasionally cause hemolytic anemia. Furthermore, biologic medications for the treatment of moderate-to-severe psoriasis and multiple squamous cell carcinoma have proven to be successful and safe; nevertheless, a small percentage of patients do not react to biologic treatment in the long term or do not respond at all. Based on the data from the China Food and Drug Administration, the majority of chemical drugs are utilized as the topical formulations, while Chinese medicines are mainly delivered by an oral route, suggesting that the market for topical preparations of Chinese medicine to treat skin diseases like psoriasis is worth exploration. This large interindividual diversity in response could be caused by changes in genes that encode proteins implicated in the disease’s pathologic environment or the medication’s mechanism of action. Pharmacogenetics is the study of the association between genetic differences and medication response, which is valuable for identifying nonresponsive patients and those who are more likely to suffer toxicity as a result of treatment. This study highlights the pharmacogenetic recommendations for dermatology therapies that have the strongest evidence at this time, highlighting those that have been incorporated in clinical practice guides. Pharmacogenetic clinical guidelines for multiple squamous cell carcinoma and psoriasis vulgaris were found in this investigation. Here, for multiple squamous cell carcinoma trichohyalin-like 1 (TCHHL1), 5-fluorouracil (5-FU) 0.5% is recommended. Along with that dapsone, Valosin-containing protein can be recommended for treating the psoriasis vulgaris. We made some clinical trials over the two diseases, and from the result obtained, we hypothesize that the suggested drug may be a novel therapeutic target in treating the multiple squamous cell carcinoma with psoriasis vulgaris.

Objective To explore the role of a first-aid fast track channel in rescuing children with airway foreign bodies and to analyse and summarize the experience and lessons of the first-aid fast track channel in rescuing airway foreign bodies from patients in critical condition. Methods We retrospectively reviewed the medical records of children with airway foreign bodies rescued by first-aid fast track channels admitted to our hospital from January 2017 to December 2020. The corresponding clinical features, treatments, and prognoses were summarized. Results Clinical data from 21 cases of first-aid fast track channel patients were retrospectively collected, including 12 males and 9 females aged 9–18 months. Cough was the most frequently exhibited symptom (100.0%), followed by III inspiratory dyspnoea (71.4%). Regarding the location of foreign bodies, 5 cases (23.8%) had glottic foreign bodies, 10 cases (47.6%) had tracheal foreign bodies, and 6 cases (28.6%) had bilateral bronchial foreign bodies. The most common type of FB was organic. FB removal was performed by rigid bronchoscopy in every case, and there were no complications of laryngeal oedema, subcutaneous emphysema, or pneumothorax. No tracheotomy was performed in any of the children. Conclusion The first-aid fast track channel for airway foreign bodies saves a valuable time for rescue, highlights the purpose of rescue, improves the success rate of rescue and the quality of life of children, and is of great value for the treatment of critical tracheal foreign bodies. It is necessary to regularly summarize the experience of the first-aid fast track channel of airway foreign bodies and further optimize the setting of the first-aid fast track channel.