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"Herrero, M"
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كليوباترا
هذا الكتاب مخصص للأطفال يستهدف الطفولة المبكرة وتعمل علي اسثمار الطفل في بناء المهارات المختلفة المرتبطة بالخيال والأبتكار وقوة الشخصية والبحث عن حلول إبداعية ويستمد الطفل الكثير من العلم والمعرفة والمعلومات من المنهج السلوكي التربوي رائع يعلم الطفل كيف يستخلص من مشكلاته وكيف يبني شخصيته بشكل مميز ويعطي المربي حلولا لحل مشكلات أبنه تعنيه عن تجاوز الأزمة وإنهائها.
BOOK
Impact of Biogenic Amines on Food Quality and Safety
Today, food safety and quality are some of the main concerns of consumer and health agencies around the world. Our current lifestyle and market globalization have led to an increase in the number of people affected by food poisoning. Foodborne illness and food poisoning have different origins (bacteria, virus, parasites, mold, contaminants, etc.), and some cases of food poisoning can be traced back to chemical and natural toxins. One of the toxins targeted by the Food and Drug Administration (FDA) and European Food Safety Authority (EFSA) is the biogenic amine histamine. Biogenic amines (BAs) in food constitute a potential public health concern due to their physiological and toxicological effects. The consumption of foods containing high concentrations of biogenic amines has been associated with health hazards. In recent years there has been an increase in the number of food poisoning cases associated with BAs in food, mainly in relation to histamines in fish. We need to gain a better understanding of the origin of foodborne disease and how to control it if we expect to keep people from getting ill. Biogenic amines are found in varying concentrations in a wide range of foods (fish, cheese, meat, wine, beer, vegetables, etc.), and BA formation is influenced by different factors associated with the raw material making up food products, microorganisms, processing, and conservation conditions. Moreover, BAs are thermostable. Biogenic amines also play an important role as indicators of food quality and/or acceptability. Hence, BAs need to be controlled in order to ensure high levels of food quality and safety. All of these aspects will be addressed in this review.
Journal Article
كليوباترا
هذا الكتاب مخصص للأطفال يستهدف الطفولة المبكرة وتعمل علي اسثمار الطفل في بناء المهارات المختلفة المرتبطة بالخيال والأبتكار وقوة الشخصية والبحث عن حلول إبداعية ويستمد الطفل الكثير من العلم والمعرفة والمعلومات من المنهج السلوكي التربوي رائع يعلم الطفل كيف يستخلص من مشكلاته وكيف يبني شخصيته بشكل مميز ويعطي المربي حلولا لحل مشكلات أبنه تعنيه عن تجاوز الأزمة وإنهائها.
BOOK
Exploring sizable triple Higgs couplings in the 2HDM
An important task at future colliders is the measurement of the triple Higgs coupling. Depending on its size relative to the Standard Model (SM) value, certain collider options result in a higher experimental accuracy. Within the framework of Two Higgs Doublet Models (2HDM) types I and II we investigate the allowed ranges for all triple Higgs couplings involving at least one light, SM-like Higgs boson. We take into account theoretical constraints (unitarity, stability), experimental constraints from direct Higgs-boson searches, measurements of the SM-like Higgs-boson properties, flavor observables and electroweak precision data. We find that the SM-type triple Higgs coupling w.r.t. its SM value, λhhh/λSM, can range between ∼-0.5 and ∼1.5. Depending on which value is realized, the HL-LHC can compete with, or is clearly inferior to the ILC. We find the coupling λhhH between ∼-1.5 and ∼1.5. Triple Higgs couplings involving two heavy Higgs bosons, λhHH, λhAA and λhH+H- can reach values up to O(10), roughly independent of the 2HDM type. This can lead to potentially strongly enhanced production of two Higgs-bosons at the HL-LHC or high-energy e+e- colliders.
Journal Article
Effect of CYP3A53 on kidney transplant recipients treated with tacrolimus: a systematic review and meta-analysis of observational studies
The highly variable pharmacokinetics of tacrolimus can hamper the optimal management of kidney transplant patients. This variability has been attributed to the genetic polymorphism of
CYP3A5 6986A>G
, but the evidence is not clear. We conducted a meta-analysis of studies evaluating the effect of
CYP3A5
polymorphism on kidney transplant recipients with tacrolimus plasma concentration divided by daily dose per body weight (C/D) and clinical outcomes. We searched in MEDLINE and EMBASE. We found evidence suggesting a significantly lower C/D among
CYP3A5
*1 allele carriers compared with carriers of the
CYP3A5
*3/*3 genotype at weeks 1 and 2, and months 1, 3, 6 and 12. We demonstrated that the expresser genotype might have higher risk of acute rejection and chronic nephrotoxicity. In conclusion,
CYP3A5 6986A>G
polymorphism can affect tacrolimus pharmacokinetics and the incidence of acute rejection and chronic nephrotoxicity on kidney transplant recipients. Patients at high risk of developing tacrolimus-related complications could be detected even before their kidney transplant.
Journal Article
Global rangeland production systems and livelihoods at threat under climate change and variability
Rangelands are one of the Earth's major ice-free land cover types. They provide food and support livelihoods for millions of people in addition to delivering important ecosystems services. However, rangelands are at threat from climate change, although the extent and magnitude of the potential impacts are poorly understood. Any declines in vegetation biomass and fluctuations in grazing availability would be of concern for food production and ecosystem integrity and functionality. In this study, we use a global rangeland model in combination with livestock and socio-economic datasets to identify where and to what extent rangeland systems may be at climatic risk. Overall, mean herbaceous biomass is projected to decrease across global rangelands between 2000 and 2050 under RCP 8.5 (−4.7%), while inter- (year-to-year) and intra- (month-to-month) annual variabilities are projected to increase (+21.3% and +8.2%, respectively). These averaged global estimates mask large spatial heterogeneities, with 74% of global rangeland area projected to experience a decline in mean biomass, 64% an increase in inter-annual variability and 54% an increase in intra-annual variability. Half of global rangeland areas are projected to experience simultaneously a decrease in mean biomass and an increase in inter-annual variability-vegetation trends both potentially harmful for livestock production. These regions include notably the Sahel, Australia, Mongolia, China, Uzbekistan and Turkmenistan and support 376 million people and 174 million ruminant Tropical Livestock Units. Additionally, the rangeland communities currently the most vulnerable (here, with the lowest livestock productivities and economic development levels and with the highest projected increases in human population densities) are projected to also experience the most damaging vegetation trends for livestock production. Although the capacity of rangeland systems to adapt is highly complex, analyses such as these generate some of the information required to inform options to facilitate pastoral system mitigation and adaptation strategies under climate change.
Journal Article
Triple Higgs couplings in the 2HDM: the complete picture
The measurement of the triple Higgs coupling is one of the main tasks of the (HL-)LHC and future lepton colliders. Similarly, triple Higgs couplings involving BSM Higgs bosons are of high interest. Within the framework of Two Higgs Doublet Models (2HDM) we investigate the allowed ranges for all triple Higgs couplings involving at least one light, SM-like Higgs boson. We present newly the allowed ranges for 2HDM type III and IV and update the results within the type I and II. We take into account theoretical constraints from unitarity and stability, experimental constraints from direct BSM Higgs-boson searches, measurements of the rates of the SM-like Higgs-boson at the LHC, as well as flavor observables and electroweak precision data. For the SM-type triple Higgs coupling w.r.t. its SM value, λhhh/λSM, we find allowed intervals of ∼[-0.5,1.3] in type I and ∼[0.5,1.0] in the other Yukawa types. These allowed ranges have important implications for the experimental determination of this coupling at future collider experiments. We find the coupling λhhH between ∼-1.5 and ∼+1.5 in the four Yukawa types. For the triple Higgs couplings involving two heavy neutral Higgs bosons, λhHH and λhAA we find values between ∼-0.5 and ∼16, and between ∼-1 and ∼32 for λhH+H-. These potentially large values could lead to strongly enhanced production of two Higgs-bosons at the HL-LHC or high-energy lepton colliders.
Journal Article
Sustainable Intensification in Agriculture: Premises and Policies
Clearer understanding is needed of the premises underlying SI and how it relates to food-system priorities.
Food security is high on the global policy agenda. Demand for food is increasing as populations grow and gain wealth to purchase more varied and resource-intensive diets. There is increased competition for land, water, energy, and other inputs into food production. Climate change poses challenges to agriculture, particularly in developing countries (
1
), and many current farming practices damage the environment and are a major source of greenhouse gases (GHG). In an increasingly globalized world, food insecurity in one region can have widespread political and economic ramifications (
2
).
Journal Article
First modern human settlement recorded in the Iberian hinterland occurred during Heinrich Stadial 2 within harsh environmental conditions
As the south-westernmost region of Europe, the Iberian Peninsula stands as a key area for understanding the process of modern human dispersal into Eurasia. However, the precise timing, ecological setting and cultural context of this process remains controversial concerning its spatiotemporal distribution within the different regions of the peninsula. While traditional models assumed that the whole Iberian hinterland was avoided by modern humans due to ecological factors until the retreat of the Last Glacial Maximum, recent research has demonstrated that hunter-gatherers entered the Iberian interior at least during Solutrean times. We provide a multi-proxy geoarchaeological, chronometric and paleoecological study on human–environment interactions based on the key site of Peña Capón (Guadalajara, Spain). Results show (1) that this site hosts the oldest modern human presence recorded to date in central Iberia, associated to pre-Solutrean cultural traditions around 26,000 years ago, and (2) that this presence occurred during Heinrich Stadial 2 within harsh environmental conditions. These findings demonstrate that this area of the Iberian hinterland was recurrently occupied regardless of climate and environmental variability, thus challenging the widely accepted hypothesis that ecological risk hampered the human settlement of the Iberian interior highlands since the first arrival of modern humans to Southwest Europe.
Journal Article