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"Hesse, Karen"
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Aleutian sparrow
An Aleutian Islander recounts her suffering during World War II in American internment camps designed to \"protect\" the population from the invading Japanese.
Book
Lavender
When her Aunt Alix is taken to the hospital to have her baby, Codie is determined to finish the quilt she has been making for her new cousin.
Book
Sable
Tate Marshall is delighted when a stray dog turns up in the yard one day, but Sable, named for her dark, silky fur, causes trouble with the neighbors and has to go.
Book
WILD BOY OF THE ROAD
Route 66 was a road of flight but it was also a road of family, which makes the next excerpt all the more poignant. This poem is the story of a boy, thin as a pole and forced to set out on his own, without his family, traveling west to God knows where.
Much has been written of the ancient vehicles that carried migrants from Oklahoma. It’s instructive to remember that those who couldn’t afford a jalopy still managed to find their way out of the Dust Bowl—by walking Route 66. In this and other accounts of the Okies’
Book Chapter
Stowaway
A fictionalized journal relates the experiences of a young stowaway from 1768 to 1771 aboard the Endeavor which sailed around the world under Captain James Cook.
Book
Simultaneous single-cell calcium imaging of neuronal population activity and brain-wide BOLD fMRI
Blood Oxygen Level-Dependent (BOLD) functional Magnetic Resonance Imaging (fMRI) allows for the non-invasive, indirect recording of neural activity across the whole brain in both animals and humans. However, the relationship between the local neural population activity and the vascular activity throughout the rodent brain is not completely understood. To investigate this relationship, we introduce a novel MRI compatible single-photon microscope capable of measuring cellular resolution Ca2+ activity of genetically defined neurons during whole-brain BOLD fMRI in awake behaving mice. Using this combined imaging approach, we found a difference in activity patterns between cells which was dependent on their location with respect to the vasculature. Notably, neurons near the vasculature showed pronounced negative activity during contralateral whisker movements at 3 Hz. In a second proof of concept experiment, we demonstrated the potential of recording both local neural activities, like those in the barrel field (SSp-bfd), and BOLD fMRI readings from interlinked brain regions. In sum, the presented technological advancement paves the way for studies examining the interplay between local brain circuits and overarching brain functions. In addition, the new approach enhances our understanding of the intricate vascular BOLD fMRI signal, providing insights into the determinants of local neurovascular functions and the brain's organizational framework across various scales.Competing Interest StatementThe authors have declared no competing interest.Footnotes* https://github.com/rlemubaghs/open_mrscope.git* https://github.com/rlemubaghs/open_mrcradle_mouse.git
Paper
A Healthy, Flourishing Weed
Hesse shares her experience winning the Newbery. In her Newbery year she was invited to speak all over the country. She accepted every invitation. She met wonderful people, extraordinary people. At the end of the year, she was very, very tired, but it was a good tired. And the doors that opened during that year never fully closed again. She is now on the threshold of her seventieth year. After twenty-four beautifully published books, the fierce need to write that once woke her in the middle of the night is quieter now. Winning the Newbery for Out of the Dust has made her feel visible and whole.
Magazine Article