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"Jing, Hui"
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A Nano-Micro Engineering Nanofiber for Electromagnetic Absorber, Green Shielding and Sensor
HighlightsThe role of electron transport characteristics in electromagnetic (EM) attenuation can be generalized to other EM functional materials.The integrated functions of efficient EM absorption and green shielding open the view of EM multifunctional materials.A novel sensing mechanism based on intrinsic EM attenuation performance and EM resonance coupling effect is revealed.It is extremely unattainable for a material to simultaneously obtain efficient electromagnetic (EM) absorption and green shielding performance, which has not been reported due to the competition between conduction loss and reflection. Herein, by tailoring the internal structure through nano-micro engineering, a NiCo2O4 nanofiber with integrated EM absorbing and green shielding as well as strain sensing functions is obtained. With the improvement of charge transport capability of the nanofiber, the performance can be converted from EM absorption to shielding, or even coexist. Particularly, as the conductivity rising, the reflection loss declines from − 52.72 to − 10.5 dB, while the EM interference shielding effectiveness increases to 13.4 dB, suggesting the coexistence of the two EM functions. Furthermore, based on the high EM absorption, a strain sensor is designed through the resonance coupling of the patterned NiCo2O4 structure. These strategies for tuning EM performance and constructing devices can be extended to other EM functional materials to promote the development of electromagnetic driven devices.Graphic Abstract
Journal Article
البيئة الخضراء كنز ثمين : 40 عاما من الجهود الصينية في حماية البيئة /
يستعرض هذا الكتاب مسيرة التطور التقني لحماية البيئة بمفهومها الشامل بالصين، وهو في ذاته بمنزلة إعادة النظر لمسيرة تطور مجال حماية البيئة في الصين من خلال زاويتي التاريخ والتقنيات. وفي سبيل ذلك يتناول الكتاب عددا من المحاور الرئيسية منها، تطور سياسات تقنيات حماية البيئة، ومسار تقدم البحوث العلمية في مجال حماية البيئة في فترة السبعينيات والثمانينيات من القرن الماضي وتقنيات إدارة المهدورات ومعالجتها وإدارة نفايات الصناعة والنفايات الغازية ومعالجتها، بالإضافة إلى سبل معالجة السميات الناتجة عن المبيدات الزراعية وتلوث الغذاء وغيرها. كما يتناول هذا الكتاب مجموعة من الآليات ذات الصلة بتطور تقنيات الرصد البيئي من خلال الدراسات ذات الصلة بالصحة البيئية، ويستعرض تطور سياسة تقنيات حماية البيئة وأوضاع تطور تقنيات التحكم في تلوث المياه وتطور تقنية التحكم في تلوث الهواء، وكذلك يستعرض واقع تطور تقنيات التحكم في الضوضاء، وتقنيات الاستغلال الشامل للمواد الصلبة وتكنولوجيا معالجة تلوث التربة والسياسات العلمية والتكنولوجية وتطوير تكنولوجيا حماية البيئة في العصر الحديث.
Book
SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice
The COVID-19 pandemic continues to spread throughout the world with an urgent need for a safe and protective vaccine to effectuate herd protection and control the spread of SARS-CoV-2. Here, we report the development of a SARS-CoV-2 subunit vaccine (NVX-CoV2373) from the full-length spike (S) protein that is stable in the prefusion conformation. NVX-CoV2373 S form 27.2-nm nanoparticles that are thermostable and bind with high affinity to the human angiotensin-converting enzyme 2 (hACE2) receptor. In mice, low-dose NVX-CoV2373 with saponin-based Matrix-M adjuvant elicit high titer anti-S IgG that blocks hACE2 receptor binding, neutralize virus, and protects against SARS-CoV-2 challenge with no evidence of vaccine-associated enhanced respiratory disease. NVX-CoV2373 also elicits multifunctional CD4
+
and CD8
+
T cells, CD4
+
follicular helper T cells (Tfh), and antigen-specific germinal center (GC) B cells in the spleen. In baboons, low-dose levels of NVX-CoV2373 with Matrix-M was also highly immunogenic and elicited high titer anti-S antibodies and functional antibodies that block S-protein binding to hACE2 and neutralize virus infection and antigen-specific T cells. These results support the ongoing phase 1/2 clinical evaluation of the safety and immunogenicity of NVX-CoV2373 with Matrix-M (NCT04368988).
Here, the authors characterize a SARS-CoV-2 subunit vaccine candidate that contains full-length spike protein stabilized in its prefusion conformation, and show immunogenicity in baboons and protection in mice with Matrix-M adjuvanted vaccine.
Journal Article
إحضار الكتب المقدسة
عاش النبيل كو في بلدة تونغتايفو كان رجلا طيبا يحب الخير وعرض أن يستضيف سان تسانغ وتلاميذه لفترة طويلة، ولكنهم رفضوا رغم إلحاح عائلة النبيل؛ فلم يجدوا بدا من توديعهم. وما إن غادر سان تسانغ وتلاميذه حتى تعرض بيت النبيل للسرقة، وقتل النبيل كو، فأضمرت زوجته الضغينة لسان تسانغ وتلاميذه لأنهم لم يوافقوا على البقاء رغم الإلحاح عليهم، واتهمت الزوجة سان تسانغ وتلاميذه زورا بارتكاب الجريمة، وقدمت دعوى لمقاضاتهم. وفي طريق اللصوص للفرار، أرادوا سرقة سان تسانغ وتلاميذه أيضا، ولكن وو كونغ قبض عليهم، وحينما التقى سان تسانغ وتلاميذه بالضباط والجنود الذين جاؤوا لملاحقتهم، حدث سوء فهم أدى لاتهام سان تسانغ وتلاميذه.
Book
NVX-CoV2373 vaccine protects cynomolgus macaque upper and lower airways against SARS-CoV-2 challenge
•Full-length SARS-CoV-2 prefusion spike with Matrix-M™ (NVX-CoV2373) vaccine.•Induced hACE2 receptor blocking and neutralizing antibodies in macaques.•Vaccine protected against SARS-CoV-2 replication in the nose and lungs.•Absence of pulmonary pathology in NVX-CoV2373 vaccinated macaques.
There is an urgent need for a safe and protective vaccine to control the global spread of SARS-CoV-2 and prevent COVID-19. Here, we report the immunogenicity and protective efficacy of a SARS-CoV-2 subunit vaccine (NVX-CoV2373) produced from the full-length SARS-CoV-2 spike (S) glycoprotein stabilized in the prefusion conformation. Cynomolgus macaques (Macaca fascicularis) immunized with NVX-CoV2373 and the saponin-based Matrix-M™ adjuvant induced anti-S antibody that was neutralizing and blocked binding to the human angiotensin-converting enzyme 2 (hACE2) receptor. Following intranasal and intratracheal challenge with SARS-CoV-2, immunized macaques were protected against upper and lower infection and pulmonary disease. These results support ongoing phase 1/2 clinical studies of the safety and immunogenicity of NVX-CoV2327 vaccine (NCT04368988).
Journal Article
Industry 4.0: a way from mass customization to mass personalization production
Although mass customization, which utilizes modularization to simultaneously increase product variety and maintain mass production (MP) efficiency, has become a trend in recent times, there are some limitations to mass customization. Firstly, customers do not participate wholeheartedly in the design phase. Secondly, potential combinations are predetermined by designers. Thirdly, the concept of mass customization is not necessary to satisfy individual requirements and is not capable of providing personalized services and goods. Industry 4.0 is a collective term for technologies and concepts of value chain organization. Based on the technological concepts of radio frequency identification, cyber-physical system, the Internet of things, Internet of service, and data mining, Industry 4.0 will enable novel forms of personalization. Direct customer input to design will enable companies to increasingly produce customized products with shorter cycle-times and lower costs than those associated with standardization and MP. The producer and the customer will share in the new value created. To overcome the gaps between mass customization and mass personalization, this paper presents a framework for mass personalization production based on the concepts of Industry 4.0. Several industrial practices and a lab demonstration show how we can realize mass personalization.
Journal Article
Application of Improved K-Means Algorithm in Collaborative Recommendation System
With the explosive growth of information resources in the age of big data, mankind has gradually fallen into a serious “information overload” situation. In the face of massive data, collaborative filtering algorithm plays an important role in information filtering and information refinement. However, the recommendation quality and efficiency of collaborative filtering recommendation algorithms are low. The research combines the improved artificial bee colony algorithm with K-means algorithm and applies them to the recommendation system to form a collaborative filtering recommendation algorithm. The experimental results show that the MAE value of the new fitness function is 0.767 on average, which has good separation and compactness in clustering effect. It shows high search accuracy and speed. Compared with the original collaborative filtering algorithm, the average absolute error value of this algorithm is low, and the running time is only 50 s. It improves the recommendation quality and ensures the recommendation efficiency, providing a new research path for the improvement of collaborative filtering recommendation algorithm.
Journal Article
Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions
Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain tumor microenvironment in a reproducible and scalable system, we developed a rapid three-dimensional (3D) bioprinting method to construct clinically relevant biomimetic tissue models. In recurrent glioblastoma, macrophages/microglia prominently contribute to the tumor mass. To parse the function of macrophages in 3D, we compared the growth of glioblastoma stem cells (GSCs) alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel, with or without macrophage. Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival, maintenance of stemness, invasion, and drug resistance. Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs, relative to sphere culture. Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity, cellular crosstalk, invasion, context-specific functional dependencies, as well as immunologic interactions in a species-matched neural environment.
Journal Article