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"Jones, Nancy J"
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Tejanaland : a writing life in four acts
\"This collection by Teresa Palomo Acosta -- poet, historian, author, and activist -- spans three decades of her writing, from 1988 through 2018. The collection is divided into four parts: poems, essays, a children's story, and plays. Each work addresses cultural, gender, historical, and political realities that she experienced from her childhood to the present. The plays, set in the Central Texas Blackland Prairies where Acosta was raised, provide a unique Latina vision of memory, identity, and experience and are a vital contribution to Chicana feminist thought. The essays focus on Acosta's literary heroes Jovita González Mireles, Sara Estela Ramírez, and Elena Zamora O'Shea, important writers who contributed significantly to Tejana literature and to Texas letters. The children's story, 'Colchas, Colchitas,' is based on Acosta's most notable poem, 'My Mother Pieced Quilts,' which pays homage to her mother and the many women of her generation who employed needles and thread, creating both practical and symbolic artifacts. This collection is a creative and, indeed, essential expansion of boundaries for what we think of as history, offering a unique and compelling look into the lived experiences and interior contemplations of a Texas artist well worth knowing. Readers will increase their understanding of Tejana experience in the late twentieth and early twenty-first centuries. Tejanaland promises to become an important addition to the cultural record, informing historical perspectives on the experiences of Tejana women and contributing significantly to the existing body of work from Tejana writers. Teresa Palomo Acosta is cofounder and former vice president of the Ruthe Winegarten Memorial Foundation for Texas Women's History. She is the author of many works of fiction and poetry and is coauthor of Las Tejanas: 300 Years of History. She lives in Austin\"-- Provided by publisher.
BOOK
Keeping It Living
The European explorers who first visited the Northwest Coast of North America assumed that the entire region was virtually untouched wilderness whose occupants used the land only minimally, hunting and gathering shoots, roots, and berries that were peripheral to a diet and culture focused on salmon. Colonizers who followed the explorers used these claims to justify the displacement of Native groups from their lands. Scholars now understand, however, that Northwest Coast peoples were actively cultivating plants well before their first contact with Europeans. This book is the first comprehensive overview of how Northwest Coast Native Americans managed the landscape and cared for the plant communities on which they depended.
Bringing together some of the world's most prominent specialists on Northwest Coast cultures,Keeping It Livingtells the story of traditional plant cultivation practices found from the Oregon coast to Southeast Alaska. It explores tobacco gardens among the Haida and Tlingit, managed camas plots among the Coast Salish of Puget Sound and the Strait of Georgia, estuarine root gardens along the central coast of British Columbia, wapato maintenance on the Columbia and Fraser Rivers, and tended berry plots up and down the entire coast.
With contributions from ethnobotanists, archaeologists, anthropologists, geographers, ecologists, and Native American scholars and elders,Keeping It Livingdocuments practices, many unknown to European peoples, that involve manipulating plants as well as their environments in ways that enhanced culturally preferred plants and plant communities. It describes how indigenous peoples of this region used and cared for over 300 different species of plants, from the lofty red cedar to diminutive plants of backwater bogs.
eBook
Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine
How well do serum samples from persons vaccinated with the mRNA-1273 vaccine neutralize the P.1 lineage, the B.1.1.7 lineage, the B.1.1.7 lineage plus the E484K mutation, the B.1.351 lineage, and the B.1.427/B.1.429 lineage of SARS-CoV-2? This study provides an answer.
Journal Article
Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis
In this trial, 1-year GVHD-free, relapse-free survival after stem-cell transplantation was 52.7% in the cyclophosphamide–tacrolimus–mycophenolate mofetil group and 34.9% in the tacrolimus–methotrexate group.
Journal Article
A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone
Antigens displayed on self-assembling nanoparticles can stimulate strong immune responses and have been playing an increasingly prominent role in structure-based vaccines. However, the development of such immunogens is often complicated by inefficiencies in their production. To alleviate this issue, we developed a plug-and-play platform using the spontaneous isopeptide-bond formation of the SpyTag:SpyCatcher system to display trimeric antigens on self-assembling nanoparticles, including the 60-subunit
Aquifex aeolicus
lumazine synthase (LuS) and the 24-subunit
Helicobacter pylori
ferritin. LuS and ferritin coupled to SpyTag expressed well in a mammalian expression system when an
N-
linked glycan was added to the nanoparticle surface. The respiratory syncytial virus fusion (F) glycoprotein trimer—stabilized in the prefusion conformation and fused with SpyCatcher—could be efficiently conjugated to LuS-SpyTag or ferritin-SpyTag, enabling multivalent display of F trimers with prefusion antigenicity. Similarly, F-glycoprotein trimers from human parainfluenza virus-type 3 and spike-glycoprotein trimers from SARS-CoV-2 could be displayed on LuS nanoparticles with decent yield and antigenicity. Notably, murine vaccination with 0.08 µg of SARS-CoV-2 spike-LuS nanoparticle elicited similar neutralizing responses as 2.0 µg of spike, which was ~ 25-fold higher on a weight-per-weight basis. The versatile platform described here thus allows for multivalent plug-and-play presentation on self-assembling nanoparticles of trimeric viral antigens, with SARS-CoV-2 spike-LuS nanoparticles inducing particularly potent neutralizing responses.
Journal Article
The Increasing Incidence of Young-Onset Colorectal Cancer: A Call to Action
In the United States, colorectal cancer (CRC) is the third most common and second most lethal cancer. More than one-tenth of CRC cases (11% of colon cancers and 18% of rectal cancers) have a young onset (ie, occurring in individuals younger than 50 years). The CRC incidence and mortality rates are decreasing among all age groups older than 50 years, yet increasing in younger individuals for whom screening use is limited and key symptoms may go unrecognized. Familial syndromes account for approximately 20% of young-onset CRCs, and the remainder are typically microsatellite stable cancers, which are more commonly diploid than similar tumors in older individuals. Young-onset CRCs are more likely to occur in the distal colon or rectum, be poorly differentiated, have mucinous and signet ring features, and present at advanced stages. Yet, stage-specific survival in patients with young-onset CRC is comparable to that of patients with later-onset cancer. Primary care physicians have an important opportunity to identify high-risk young individuals for screening and to promptly evaluate CRC symptoms. Risk modification, targeted screening, and prophylactic surgery may benefit individuals with a predisposing hereditary syndrome or condition (eg, inflammatory bowel disease) or a family history of CRC or advanced adenomatous polyps. When apparently average-risk young adults present with CRC-like symptoms (eg, unexplained persistent rectal bleeding, anemia, and abdominal pain), endoscopic work-ups can expedite diagnosis. Early screening in high-risk individuals and thorough diagnostic work-ups in symptomatic young adults may improve young-onset CRC trends.
Journal Article