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"Kelly, Daniel"
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Midnight & Moon
\"Moon cannot see but he hears sounds that other horses ignore: the eggshell crack of a meadow lark hatching. The glide of a salamander into the pond. Clara does not speak but she hears sounds that other children ignore: the hum of the oven when her mother bakes muffins. The sound of the cat's paws on the kitchen floor. Both the foal and the little girl live with challenges. Both also have special qualities, which are recognized by friends who are open to seeing them. Midnight and Moon is about the rare and wonderful friendship that can form between opposites, a friendship that enriches both. This story shows us that our differences are positives, that the world needs both Claras and Jacks, Midnights and Moons.\"-- Front jacket flap.
Book
Skeletal muscle mitochondrial remodeling in exercise and diseases
Skeletal muscle fitness and plasticity is an important determinant of human health and disease. Mitochondria are essential for maintaining skeletal muscle energy homeostasis by adaptive re-programming to meet the demands imposed by a myriad of physiologic or pathophysiological stresses. Skeletal muscle mitochondrial dysfunction has been implicated in the pathogenesis of many diseases, including muscular dystrophy, atrophy, type 2 diabetes, and aging-related sarcopenia. Notably, exercise counteracts the effects of many chronic diseases on skeletal muscle mitochondrial function. Recent studies have revealed a finely tuned regulatory network that orchestrates skeletal muscle mitochondrial biogenesis and function in response to exercise and in disease states. In addition, increasing evidence suggests that mitochondria also serve to “communicate” with the nucleus and mediate adaptive genomic re-programming. Here we review the current state of knowledge relevant to the dynamic remodeling of skeletal muscle mitochondria in response to exercise and in disease states.
Journal Article
The wellness lifestyle : a chef's recipe for real life
The path to total wellness is a lifelong journey of self-exploration and adaptation. Chef D and Dr. K explain how to implement and maintain effective behavoir changes, including better ways to move, like yoga; better ways to think, like through meditation; and better ways to eat, with easy recipes for whole, healthful foods.
Book
Tuning Alginate Bioink Stiffness and Composition for Controlled Growth Factor Delivery and to Spatially Direct MSC Fate within Bioprinted Tissues
Alginate is a commonly used bioink in 3D bioprinting. Matrix stiffness is a key determinant of mesenchymal stem cell (MSC) differentiation, suggesting that modulation of alginate bioink mechanical properties represents a promising strategy to spatially regulate MSC fate within bioprinted tissues. In this study, we define a printability window for alginate of differing molecular weight (MW) by systematically varying the ratio of alginate to ionic crosslinker within the bioink. We demonstrate that the MW of such alginate bioinks, as well as the choice of ionic crosslinker, can be tuned to control the mechanical properties (Young’s Modulus, Degradation Rate) of 3D printed constructs. These same factors are also shown to influence growth factor release from the bioinks. We next explored if spatially modulating the stiffness of 3D bioprinted hydrogels could be used to direct MSC fate inside printed tissues. Using the same alginate and crosslinker, but varying the crosslinking ratio, it is possible to bioprint constructs with spatially varying mechanical microenvironments. Moreover, these spatially varying microenvironments were found to have a significant effect on the fate of MSCs within the alginate bioinks, with stiffer regions of the bioprinted construct preferentially supporting osteogenesis over adipogenesis.
Journal Article
Replenishing the physician-scientist pipeline in the post–late bloomer era
In a speech, Kelly discusses the call to action to expand and maintain the precious pool of physician-scientists. He would like to begin by reminding everyone of two historic eras that spawned a rapid expansion of physician-scientists in the US. First, under the visionary leadership of Dr James Shannon, a series of new programs was launched aimed at formally supporting the scientific training of physicians. The second development was more accidental and involved the civil unrest of the late 1960s, driven in part by the Vietnam War. In partnership with American Physician Scientists Association (APSA), they propose the Association of American Physicians (AAP)-APSA Longitudinal Coaching Program. This approach will match single- and dual-degree medical student APSA members with AAP mentor-coaches who will serve as personalized career advisors for the duration of training, from medical school to independence.
Journal Article
Manta vs. Machine
\"Aqualad is the target of the Mantas and it's land versus sea in a battle of titanic proportion! Can Aquaman save his protege? Dive back into Aquaman's story as he continues his epic adventure. Black Manta and Mech Manta invade Amnesty Bay with one target in mind--Aqualad! Can Aquaman save his protege from his deadly lineage? Or will the combined might of the Mantas finally be Arthur Curry's undoing? It's land versus sea in a battle of titanic proportion!\"-- Provided by publisher.
Book
Irisin, Light My Fire
A newly discovered messenger system between muscle and fat tissue may explain the systemic benefits of exercise.
Regular physical activity confers enormous fitness benefits. Exercise training enhances muscular endurance and strength, expends calories, and combats the development of common diseases such as obesity and type 2 diabetes. The effects of exercise are systemic and seemingly cannot be explained solely by the expenditure of calories in muscle (
1
). A recent study by Böstrom
et al.
(
2
) describes a mechanism that may elucidate how total body energy expenditure is increased by exercising muscle.
Journal Article
Community Trust and the Ebola Endgame
In May, Ebola resurfaced in parts of Guinea thought to be free from the virus. Some infections in known hot spots arise from unknown transmission chains, which suggests that other cases may be hidden. Only by building community trust can we bring the epidemic to an end.
Six-year-old Fatou was exposed to Ebola at her uncle's funeral in Forécariah, a district along Guinea's border with Sierra Leone where about 50% of all Guinea's Ebola cases since February 2015 have occurred.
1
Fatou's entire family was registered as contacts to be monitored for the next 21 days, during which the disease could develop.
A contact tracer began making daily visits to check their temperatures and evaluate them for symptoms. For the first few days, everything seemed fine, but on the fifth day, Fatou was found to have fever and vomiting.
A response team was dispatched to bring her to . . .
Journal Article