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"King, Stephen Michael"
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You : a story of love and friendship
Reveals the world as a colorful, musical, and exciting place where the most special thing of all is a best friend.
Book
Evidence-Based Counselling and Psychological Therapies
Evidence-Based Counselling and Psychological Therapies assesses the impact of the international drive towards evidence-based health care on NHS policy and the provision of the psychological services in the NHS. An outstanding range of contributors provide an overview of evidence-based health care and the research methods that underpin it, demonstrating its effect on policy, provision, practitioners and patients. Their thought-provoking chapters look at a variety of relevant issues including: * generating and implementing evidence * cost-effectiveness issues * practical guidelines * practitioner research Evidence-Based Counselling and Psychological Therapies is essential for mental health professionals and trainees concerned with this movement which is having, and will continue to have a huge impact on the purchasing, provision and practice of health care.
eBook
Prudence wants a pet
Prudence wants a pet so much that she adopts a branch, a twig, a tire, and even a shoe named Formal Footwear, but none is a suitable pet for Prudence.
Book
Central neural pathway mediating splanchnic osmosensation
These studies were designed to determine the central neural pathway which transmits splanchnic osmotic information to vasopressin neurons in the hypothalamus. In order to evaluate the role of strategic brain sites, electrolytic and chemical lesions were induced into these areas one week prior to either gastric infusions of hypertonic saline (598 mOsm/kg; 2ml/4min) or hemorrhage (2.5ml/300g) in conscious rats with indwelling tail artery catheters and naso-gastric tubes. The results determined that the neural signalling of salt intake is mediated by the A1 neurons in the caudal ventrolateral medulla which project through the ventral noradrenergic bundle (VNAB) to the diagonal band of Broca (DB). Noncatecholaminergic neurons within the DB then transmit this input caudally to the AVP cells in the PVN and SON. This central osmotic pathway is mostly segregated from the catecholaminergic projections mediating the AVP response to hemorrhage as far rostral as the pons, and therefore the primary integration site of osmotic and blood volume information may be within the hypothalamus, most likely the diagonal band. The identified pathway may be vital for the proper regulation of AVP secretion as well as the modulation of other autonomic functions which are required for the maintenance of osmotic homeostasis.
Dissertation
Pea pod lullaby
Escaping flames and barbed wire, a mother, a baby, a boy, and a dog flee into a sailboat and set off to sea.
Book
Emily Loves to Bounce
Boing! [Emily] is a young child in perpetual motion. She bounces wherever she goes - high bounces, low bounces, springing bounces, and boinging bounces. Like a trampoline gymnast, she can bounce on her stomach, on her bottom, and even on one foot. In her imagination, Emily bounces along with her dinosaur, with her cat, with an elephant and with Nana Pat. And not only can she bounce, Emily can also fly like a fairy or spring like a frog or even imagine herself as a bouncing, blue spotted dog.
Magazine Article
The poet
\"Death is reporter Jack McEvoy's beat : his calling, his obsession. But this time, death brings McEvoy the story he never wanted to write -- and the mystery he desperately needs to solve. A serial killer of unprecendented savagery and cunning is at large. His targets : homicide cops, each haunted by a murder case he couldn't crack. The killer's calling card : a quotation from the works of Edgar Allan Poe. His latest victim is McEvoy's own brother. And his last... may be McEvoy himself.\"--Back cover.
Book
Best American Magazine Writing 2013
Chosen by the American Society of Magazine Editors, the stories in this anthology include National Magazine Award--winning works of public interest, reporting, feature writing, and fiction. This year's selections include Pamela Colloff (Texas Monthly) on the agonizing, decades-long struggle by a convicted murderer to prove his innocence; Dexter Filkins (The New Yorker) on the emotional effort by an Iraq War veteran to make amends for the role he played in the deaths of innocent Iraqis; Chris Jones (Esquire) on Robert A. Caro's epic, ongoing investigation into the life and work of Lyndon Johnson; Charles C. Mann (Orion) on the odds of human beings' survival as a species; and Roger Angell (The New Yorker) on aging, dying, and loss. The former infantryman Brian Mockenhaupt (Byliner) describes modern combat in Afghanistan and its ability both to forge and challenge friendships; Ta-Nehisi Coates (The Atlantic) reflects on the complex racial terrain traversed by Barack Obama; Frank Rich (New York) assesses Mitt Romney's ambiguous candidacy; and Dahlia Lithwick (Slate) looks at the current and future implications of an eventful year in Supreme Court history. The volume also includes an interview on the art of screenwriting with Terry Southern fromThe Paris Review and an award-winning short story by Stephen King published inHarper'smagazine.
eBook
The Dark Tower. The gunslinger. The battle of Tull
In a saloon in the town of Tull, the last gunslinger is approached by the bizarre figure that has a message for him. The essage in terrifying. What's worse, it is delivered by a dead man named Nort whose corpse was animated to serve this very purpose. And that is only the beginning of the horrors awaiting the gunslinger in the strange place deep within Mid-World.
Book
Early initiation of prophylactic anticoagulation for prevention of coronavirus disease 2019 mortality in patients admitted to hospital in the United States: cohort study
AbstractObjectiveTo evaluate whether early initiation of prophylactic anticoagulation compared with no anticoagulation was associated with decreased risk of death among patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United States.DesignObservational cohort study.SettingNationwide cohort of patients receiving care in the Department of Veterans Affairs, a large integrated national healthcare system.ParticipantsAll 4297 patients admitted to hospital from 1 March to 31 July 2020 with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and without a history of anticoagulation.Main outcome measuresThe main outcome was 30 day mortality. Secondary outcomes were inpatient mortality, initiating therapeutic anticoagulation (a proxy for clinical deterioration, including thromboembolic events), and bleeding that required transfusion.ResultsOf 4297 patients admitted to hospital with covid-19, 3627 (84.4%) received prophylactic anticoagulation within 24 hours of admission. More than 99% (n=3600) of treated patients received subcutaneous heparin or enoxaparin. 622 deaths occurred within 30 days of hospital admission, 513 among those who received prophylactic anticoagulation. Most deaths (510/622, 82%) occurred during hospital stay. Using inverse probability of treatment weighted analyses, the cumulative incidence of mortality at 30 days was 14.3% (95% confidence interval 13.1% to 15.5%) among those who received prophylactic anticoagulation and 18.7% (15.1% to 22.9%) among those who did not. Compared with patients who did not receive prophylactic anticoagulation, those who did had a 27% decreased risk for 30 day mortality (hazard ratio 0.73, 95% confidence interval 0.66 to 0.81). Similar associations were found for inpatient mortality and initiation of therapeutic anticoagulation. Receipt of prophylactic anticoagulation was not associated with increased risk of bleeding that required transfusion (hazard ratio 0.87, 0.71 to 1.05). Quantitative bias analysis showed that results were robust to unmeasured confounding (e-value lower 95% confidence interval 1.77 for 30 day mortality). Results persisted in several sensitivity analyses.ConclusionsEarly initiation of prophylactic anticoagulation compared with no anticoagulation among patients admitted to hospital with covid-19 was associated with a decreased risk of 30 day mortality and no increased risk of serious bleeding events. These findings provide strong real world evidence to support guidelines recommending the use of prophylactic anticoagulation as initial treatment for patients with covid-19 on hospital admission.
Journal Article