Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
186
result(s) for
"Lapointe, Julie"
Sort by:
كتابات عن (وحول) السينما التجريبية : نصوص ودراسات مختارة
المعنى هنا هو أن البعض قد يترجم رواية أو كتابا غير روائي أو دراسة قد لا تهمه مقتضياتها وموضوعاتها كثيرا وتكون ترجمته جيدة، لكن ما هو أجود أن يكون الاهتمام السابق والمواكب من التفاعل مع المادة المتوافرة بحيث يعرف المترجم عمليا وفعليا عما يتحدث عنه أصحاب النصوص. عبر هذه المتابعة واختياراته من النصوص يكشف لمن يريد عن التاريخ الجلي للسينما التجريبية والتعريف الصادق لنوع محير في تصنيفه حتى بالنسبة إلى كثير من النقاد حول العالم. يختار سرميني من الكتابات ما يكشف عن مواطن المحاولات الأولى واللاحقة منتقلا ما بين التجارب الفرنسية والأميركية وسواها وموضحا ما تعنيه الكلمة تحديدا، وكيف لجأت الأفلام التجريبية إلى الاختلاف طوعا ورغبة في توسيع مفردات السينما والصورة.
Book
One-Year Outcomes of Second-Generation Trabecular Micro-Bypass Stents (iStent Inject) Implantation with Cataract Surgery in Different Glaucoma Subtypes and Severities
PurposeTo assess the 1-year efficacy and safety of the implantation of two second-generation trabecular micro-bypass stents (iStent Inject®) with concomitant cataract surgery in various subtypes and severities of glaucoma.MethodsThis single-surgeon, consecutive case series from a Canadian academic ophthalmology center included subjects with cataract, glaucoma, and the need to reduce intraocular pressure (IOP) and/or medications. The 12-month outcomes included mean IOP and medication burden as well as the proportions of eyes with IOP ≤ 18, ≤ 15, and ≤ 12 mmHg compared to baseline. Other measures included corrected distance visual acuity (CDVA), cup-to-disc ratio (CDR), visual field mean deviation (VF MD), retinal nerve fiber layer (RNFL) thickness, ganglion cell inner plexiform layer (GCIPL) thickness, and adverse events.ResultsIn 118 eyes, mean IOP reduced from 17.00 ± 3.82 mmHg preoperatively to 13.97 ± 2.65 mmHg at the 12-month follow-up mark (17.8% reduction, p < 0.001), and mean medication burden decreased from 2.31 ± 1.33 preoperatively to 1.03 ± 1.10 medications (56% reduction, p < 0.001). After 12 months, 93% of eyes achieved IOP ≤ 18 mmHg (versus 69% preoperatively), 70% of eyes achieved IOP ≤ 15 mmHg (versus 42% preoperatively), and 29% of eyes achieved IOP ≤ 12 mmHg (versus 7% preoperatively). For all eyes, topical medications were either maintained or decreased from baseline, with ≥ 1 medication eliminated from the preoperative regimen for 83% of eyes and ≥ 2 medications eliminated for 36% of eyes. Visual acuity improved significantly, consistent with expectations for cataract surgery, while CDR, VF MD, and RNFL and GCIPL thicknesses remained stable. Safety was favorable, with no intraoperative complications and few transient adverse events postoperatively.ConclusioniStent Inject implantation with cataract surgery safely reduced IOP and medication burden in a real-world clinical population with mild to severe glaucoma, and stabilized visual field, as well as RNFL and GCIPL thicknesses on OCT.FundingThe Rapid Service Fees were funded by Glaukos Corporation.
Journal Article
Examining interprofessional collaboration in oncogenetic service delivery models for hereditary cancers: a scoping review protocol
IntroductionIn a context of limited genetic specialists, collaborative models have been proposed to ensure timely access to high quality oncogenetic services for individuals with inherited cancer susceptibility. Yet, extensive variability in the terminology used and lack of a clear understanding of how interprofessional collaboration is operationalised and evaluated currently constrains the development of a robust evidence base on the value of different approaches used to optimise access to these services. To fill in this knowledge gap, this scoping review aims to systematically unpack the nature and extent of collaboration proposed by these interventions, and synthesise the evidence available on their implementation, effectiveness and economic impact.Methods and analysisFollowing the Joanna Briggs Institute guidelines for scoping reviews, a comprehensive literature search will be conducted to identify peer-reviewed and grey literature on collaborative models used for adult patients with, or at increased risk of, hereditary breast, ovarian, colorectal and prostate cancers. An initial search was developed for Medline, Embase, CINAHL (Cumulative Index to Nursing and Allied Health Literature), Cochrane and Web of Science on 13 June 2022 and will be complemented by searches in Google and relevant websites. Documents describing either the theory of change, planning, implementation and/or evaluation of these interventions will be considered for inclusion. Results will be summarised descriptively and used to compare relevant model characteristics and synthesise evidence available on their implementation, effectiveness and economic impact. This process is expected to guide the development of a definition and typology of collaborative models in oncogenetics that could help strengthen the knowledge base on these interventions. Moreover, because we will be mapping the existing evidence on collaborative models in oncogenetics, the proposed review will help us identify areas where additional research might be needed.Ethics and disseminationThis research does not require ethics approval. Results from this review will be disseminated through peer-reviewed articles and conferences.
Journal Article
Primary care providers’ experience and satisfaction with personalised breast cancer screening risk communication: a descriptive cross-sectional study
ObjectiveTo describe primary care providers’ (PCPs) experience and satisfaction with receiving risk communication documents on their patient’s breast cancer (BC) risk assessment and proposed screening action plan.DesignDescriptive cross-sectional study.SettingA survey was distributed to all 763 PCPs linked to 1642 women participating in the Personalized Risk Assessment for Prevention and Early Detection of Breast Cancer: Integration and Implementation (PERSPECTIVE I&I) research project in Quebec, approximately 1–4 months after the delivery of the risk communication documents. The recruitment phase took place from July 2021 to July 2022.ParticipantsPCPs.Main outcome measuresDescriptive analyses were conducted to report participants’ experiences and satisfaction with receiving risk communication. Responses to two open-ended questions were subjected to content analysis.ResultsA total of 168 PCPs answered the survey, from which 73% reported being women and 74% having more than 15 years of practice. Only 38% were familiar with the risk-based BC screening approach prior to receiving their patient risk category. A majority (86%) agreed with the screening approach and would recommend it to their patients if implemented at the population level. A majority of PCPs also reported understanding the information provided (92%) and expressed agreement with the proposed BC screening action plan (89%). Some PCPs recommended simplifying the materials, acknowledging the potential increase in workload and emphasising the need for careful planning of professional training efforts.ConclusionPCPs expressed positive attitudes towards a risk-based BC screening approach and were generally satisfied with the information provided. This study suggests that, if introduced in Canada in a manner similar to the PERSPECTIVE I&I project, risk-based BC screening would likely be supported by most PCPs. However, they emphasised the importance of addressing concerns such as professional training and the potential impact on workload if the approach were to be implemented at the population level. Future qualitative studies are needed to further explore the training needs of PCPs and to develop strategies for integrating this approach with the high workloads faced by PCPs.
Journal Article
Feasibility and acceptability of a personalised primary prevention strategy for women and men at high risk of breast and prostate cancer: the 3PC study protocol for a pilot randomised controlled trial
IntroductionSeveral primary prevention strategies, including chemoprevention, prophylactic surgery and lifestyle modifications, have been shown to reduce the risk of breast cancer (BC) and prostate cancer (Pca). However, the uptake of these preventive measures is considered suboptimal, limiting their impact on cancer prevention. A personalised primary prevention strategy has yet to be tested for cancer prevention. Therefore, we aim to determine the feasibility, acceptability and potential benefits and harms of this strategy in women and men at high risk of BC and Pca.Methods and analysisThis is a two-arm, parallel-group mixed-methods pilot randomised controlled trial with a 1:1 allocation. The study aims to recruit 60 women and 60 men at high risk of BC and PCa in two specialised sites: the Breast Diseases Center and the Department of Urologic Oncology of the CHU de Québec-Université Laval, Canada. Assessments include intentions to uptake, actual uptake rates of primary preventive measures and decision regret. Feasibility and acceptability of the intervention and the study will be measured by quantifying the recruitment rate, appropriateness of randomisation process and satisfaction metrics. Data will be collected using mixed methods. Quantitative measures will be assessed at baseline and 6 months post randomisation. Quantitative analysis will include descriptive statistics for all variables of interest. Generalised linear mixed models with random intercepts will be used to assess the overall intervention effect. Semistructured interviews will be conducted at the end of follow-up, and a thematic analysis will be performed using NVivo to understand participants’ perspectives.Ethics and disseminationThe protocol was approved by the Institutional Review Board of CHU de Québec-Université Laval (4 October 2022; 2023-6315). The findings of the study will be published in a peer-reviewed journal and disseminated at national and international conferences and through social media.Trial registration numberThe protocol for this study was registered with the International Clinical Trials Registry (ISRCTN15749766) https://doi.org/10.1186/ISRCTN15749766).
Journal Article
A community pharmacy-based program to enhance adherence to adjuvant endocrine therapy among breast cancer survivors (PACHA): protocol for a pilot cluster-randomized controlled trial
Background
Adjuvant endocrine therapy (AET) is an oral treatment prescribed for 5 to 10 years to women with hormone-sensitive breast cancer. Despite the benefits of AET for reducing breast cancer recurrence, suboptimal adherence is common. Community pharmacists can play a role in supporting women with this treatment, given their frequent encounters with patients, access to refill information, and expertise in managing side effects. The goal of this pilot study is to assess the acceptability and feasibility of implementation, and preliminary effects of the PACHA program, a community pharmacy-based program designed to support women who are prescribed AET. Another goal is to assess the feasibility of a large-scale randomized controlled trial (RCT).
Methods
This is a pilot cluster-RCT using mixed-methods. A cluster consists of a pharmacy, its pharmacists, and its patients with an AET prescription in the last 30 months. Pharmacies will be recruited through targeted advertisement. Participating pharmacies will be randomized 1:1 to two groups (
n
= 33 pharmacies per group). In the first group (control), pharmacists will provide usual services to women. In the second group (intervention), pharmacists will complete web-based training and perform consultations using a standardized guide based on motivational interviewing principles and evidence-based online strategy sheets to cope with AET side effects. Women in the intervention group will have access to a website featuring video modules on AET, strategies for managing side effects, testimonials from women who have had an AET, and a list of resources. Acceptability and feasibility indicators, as well as psychosocial factors expected to influence AET adherence and treatment experience, will be collected at baseline, during, and at the end of the 6-month follow-up using online questionnaires, study data logs, and pharmacy claim records. Semi-structured interviews will be conducted to explore participants’ experiences with the program.
Discussion
Results will help to refine the program and, if the results support this, to design a full-scale cluster-RCT to assess the program’s effect on 5-year adherence and costs. If effective, this program could fill a gap in breast cancer supportive care and contribute to reducing cancer burden by improving survivorship experience and survival.
Trial registration
This trial has been approved by the Research Ethics Board of the CHU de Québec-Université Laval (MP-20–2023-6625) and registered at Clinicaltrials.gov (NCT05887102) on 2023–05-24,
https://classic.clinicaltrials.gov/ct2/show/NCT05887102
, prior to beginning the study. Protocol version 1 is dated as 2022–12-12.
Journal Article
Interaction between Postural Risk Factors and Job Strain on self-reported Musculoskeletal Symptoms among Users of Video Display Units: A three-year Prospective Study
Objective This study investigated a possible interaction between postural risk factors and job strain on the incidence proportion of self-reported musculoskeletal symptoms in the regions of the shoulder-neck, lower back, and upper limbs. Methods A cohort of white-collar workers (N=2431) was assessed with a self-administered questionnaire regarding postural risk factors and job strain at work. After a three-year follow-up, the six-month incidence proportion of musculoskeletal symptoms in the three body regions was measured with a modified version of the Nordic questionnaire. The analyses were stratified for gender. Interaction was defined as a departure from the addition of effects of individual risk factors, and its importance was estimated from the attributable proportion due to interaction and its 95% confidence interval (95% CI). Results A significant attributable proportion of 0.80 (95% CI 0.23-1.37) due to interaction between postural risk factors and job strain was observed for men in the lower back region. An indication of interaction was found for women with attributable proportions due to interaction of 0.44 (95% CI -0.06-0.94), 0.27 (95% CI -0.34-0.88) and 0.36 (95% CI -0.33-1.05) for the regions of the shoulder-neck, lower back, and upper limbs respectively. Conclusions The simultaneous presence of postural risk factors and job strain seems to increase the pathogenic effect of each exposure on the incidence proportion of musculoskeletal symptoms. This interaction effect is important for work intervention practices as success in decreasing any of these two risk factors could have the additional benefit of reducing up to 80% of new cases of musculoskeletal symptoms among participants exposed to both risk factors.
Journal Article
Is the psychological impact of genetic testing moderated by support and sharing of test results to family and friends?
Receiving the results of genetic tests for a breast and ovarian cancer susceptibility can be a stressful experience. Here we studied the effects of social support (SS) and the sharing of test results on the psychological impact of
BRCA1
/
2
test result disclosure. We also compared carriers and non-carriers on sharing, SS and psychological impact. Five-hundred and twenty-two unaffected women were followed prospectively for 2 years after receiving their test results. Psychological impact was measured on the impact of event scale. Multivariate multi-level models were used, and all the analyses were stratified depending on mutation status (carriers vs non-carriers). Two weeks after receiving their
BRCA1
/
2
results, carriers had shared their test results less frequently than non-carriers (
p
< 0.01). Sharing test results was not significantly associated with psychological impact. Availability of SS was significantly associated with better psychological adjustment across time among carriers (
p
< 0.01), but not among non-carriers. For female
BRCA1
/
2
mutation carriers, the importance of SS should be stressed, and possible ways of enlisting people in their entourage for this purpose should be discussed in the context of clinical encounters.
Journal Article
Risk-Stratified Breast Cancer Screening Incorporating a Polygenic Risk Score: A Survey of UK General Practitioners’ Knowledge and Attitudes
A polygenic risk score (PRS) quantifies the aggregated effects of common genetic variants in an individual. A ‘personalised breast cancer risk assessment’ combines PRS with other genetic and nongenetic risk factors to offer risk-stratified screening and interventions. Large-scale studies are evaluating the clinical utility and feasibility of implementing risk-stratified screening; however, General Practitioners’ (GPs) views remain largely unknown. This study aimed to explore GPs’: (i) knowledge of risk-stratified screening; (ii) attitudes towards risk-stratified screening; and (iii) preferences for continuing professional development. A cross-sectional online survey of UK GPs was conducted between July–August 2022. The survey was distributed by the Royal College of General Practitioners and via other mailing lists and social media. In total, 109 GPs completed the survey; 49% were not familiar with the concept of PRS. Regarding risk-stratified screening pathways, 75% agreed with earlier and more frequent screening for women at high risk, 43% neither agreed nor disagreed with later and less screening for women at lower-than-average risk, and 55% disagreed with completely removing screening for women at much lower risk. In total, 81% felt positive about the potential impact of risk-stratified screening towards patients and 62% felt positive about the potential impact on their practice. GPs selected training of healthcare professionals as the priority for future risk-stratified screening implementation, preferring online formats for learning. The results suggest limited knowledge of PRS and risk-stratified screening amongst GPs. Training—preferably using online learning formats—was identified as the top priority for future implementation. GPs felt positive about the potential impact of risk-stratified screening; however, there was hesitance and disagreement towards a low-risk screening pathway.
Journal Article
Parental Practices Contribution to Organizational Skills’ Improvement Following an Intervention Among ADHD Youths
This study examines whether parenting practices contribute to the improvement of Organization, Time Management and Planning (OTMP) skills following an intervention aimed to support youths with Attention Deficit Hyperactivity Disorder (ADHD) and their parents during their transition to secondary school. Families were randomly assigned to an intervention (n = 32) or a control group (n = 35) and assessed at baseline (T1), post group (T2) and post-intervention (T3). The intervention combines three components (child group, parent group and mentorship). Multivariate regression analysis and test of indirect effects were conducted using PROCESS software. Intervention effects on OTMP skills improvement (T3) was significant both directly, and via parental consistency at T2. The study shows the relevance of targeting consistency in parenting practices at a pivotal moment for children, the transition between primary (Grade 6) to high school (Secondary 1). It also highlights the relevance of directly addressing OTMP skills with ADHD youths.
Journal Article