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result(s) for
"Lei, Kezheng"
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Functionalized MoS2-nanosheets with NIR-Triggered nitric oxide delivery and photothermal activities for synergistic antibacterial and regeneration-promoting therapy
by
Hu, Rongdang
,
Jin, Ting
,
Chen, Yuanqi
in
Acids
,
Advanced 2D nanomaterials for biomedical applications
,
Angiogenesis
2023
Bacterial infection in skin and soft tissue has emerged as a critical concern. Overreliance on antibiotic therapy has led to numerous challenges, including the emergence of multidrug-resistant bacteria and adverse drug reactions. It is imperative to develop non-antibiotic treatment strategies that not only exhibit potent antibacterial properties but also promote rapid wound healing and demonstrate biocompatibility. Herein, a novel multimodal synergistic antibacterial system (SNO-CS@MoS
2
) was developed. This system employs easily surface-modified thin-layer MoS
2
as photothermal agents and loaded with S-nitrosothiol-modified chitosan (SNO-CS) via electrostatic interactions, thus realizing the combination of NO gas therapy and photothermal therapy (PTT). Furthermore, this surface modification renders SNO-CS@MoS
2
highly stable and capable of binding with bacteria. Through PTT’s thermal energy, SNO-CS@MoS
2
rapidly generates massive NO, collaborating with PTT to achieve antibacterial effects. This synergistic therapy can swiftly disrupt the bacterial membrane, causing protein leakage and ATP synthesis function damage, ultimately eliminating bacteria. Notably, after effectively eliminating all bacteria, the residual SNO-CS@MoS
2
can create trace NO to promote fibroblast migration, proliferation, and vascular regeneration, thereby accelerating wound healing. This study concluded that SNO-CS@MoS
2
, a novel multifunctional nanomaterial with outstanding antibacterial characteristics and potential to promote wound healing, has promising applications in infected soft tissue wound treatment.
Journal Article
Preparation and Charaeterization of Hydroxyapatite/ γ-Fe203 Hybrid Nanostrueture
2013
The hybrid particles composed of hydroxyapatite (HAp) and ferrite ( γ-Fe203) were synthesized by two-step precipitation method. The effect of reaction temperature on the morphology of the hybrids was also studied. The resultant hybrids were characterized by transmission electron microscopy (TEM) and X-ray diffraction analysis(XRD). It was found that γ-Fe203 nanoparticles dispersed within the HAp matrix and these hybrids had a feather-like or spherical morphology when synthesized at 90 ℃ or room temperature, respectively. The magnetic properties of the hybrid showed good superparamagnetic feature, and they could be controlled by the external magnetic field.
Journal Article
Polarization conversion in bottom-up grown quasi-1D fibrous red phosphorus flakes
Fibrous red phosphorus (RP) has triggered growing attention as an emerging quasi-one-dimensional (quasi-1D) van der Waals crystal recently. Unfortunately, it is difficult to achieve substrate growth of high-quality fibrous RP flakes due to their inherent quasi-1D structure, which impedes their fundamental property exploration and device integration. Herein, we demonstrate a bottom-up approach for the growth of fibrous RP flakes with (001)-preferred orientation via a chemical vapor transport (CVT) reaction in the P/Sn/I
2
system. The formation of fibrous RP flakes can be attributed to the synergistic effect of Sn-mediated P
4
partial pressure and the SnI
2
capping layer-directed growth. Moreover, we investigate the optical anisotropy of the as-grown flakes, demonstrating their potential application as micro phase retarders in polarization conversion. Our developed bottom-up approach lays the foundation for studying the anisotropy and device integration of fibrous red phosphorus, opening up possibilities for the two-dimensional growth of quasi-1D van der Waals materials.
Fibrous red phosphorus (RP) has recently attracted attention due to its quasi-1D van der Waals structure and anisotropic optical properties. Here, the authors report the bottom-up growth of RP flakes via a chemical vapor transport method and their application as micro phase retarders in polarization conversion.
Journal Article
Study of the Properties and Modification Mechanism of SBS-Modified Asphalt by Dry Process
2024
SBS (styrene-butadiene-styrene block copolymer) is a thermoplastic elastomer with properties most similar to rubber. SBS asphalt modifier is mainly composed of a styrene-butadiene-styrene block copolymer with a certain amount of additives and stabilizers. SBS-modified asphalt binder has always been the most commonly used pavement material both domestically and internationally. However, conventional wet-process SBS-modified asphalt binder requires manufacturers to produce it in advance and transport it to a mixing plant for blending. This has provided an opportunity for unscrupulous businesses to reduce the amount of SBS by adding other substances, allowing inferior asphalt binder to pass inspections undetected. At the same time, conventional wet-process SBS-modified asphalt tends to undergo phase separation and experience a decline in performance as the storage time increases. However, dry-process SBS-modified asphalt can be directly added at the mixing plant, effectively addressing the issues associated with conventional wet-process SBS-modified asphalt. It also helps to reduce environmental pollution to a certain extent. This study investigates the extraction process of dry-process SBS-modified asphalt binder. It clarifies the performance and modification mechanisms of two types of dry-process SBS-modified asphalt binder at different dosages through various testing methods, including basic indicators, rheological properties, infrared spectroscopy, and fluorescence microscopy. The results indicate that due to the incorporation of oil, crosslinker, solubilizer, and other substances into dry-process SBS modifier, there is a small amount of chemical reaction with asphalt in the melting process. The high- and low-temperature properties and fatigue properties of the two dry-process SBS-modified asphalt binders at a 7% dosage are close to wet SBS-modified asphalt binder at a 5% dosage.
Journal Article
A novel bacterial cellulose membrane immobilized with human umbilical cord mesenchymal stem cells-derived exosome prevents epidural fibrosis
Failed back surgery syndrome is a situation where there is failure after lumbar surgery aimed at correcting lumbar disease that is characterized by continuous back and/or leg pain. Epidural fibrosis and adhesions are among the major causes of failed back surgery syndrome. In recent years, several biomaterials have been applied as barriers or deterrents to prevent the compression of neural structures by postsurgical fibrosis.
In this study, a new bacterial cellulose (BC) anti-adhesion membrane, composed of exosomes from human umbilical cord mesenchymal stem cells, was developed. Its structure and morphology, water content, thickness, and mechanical properties of elasticity were analyzed and characterized. The degradation of the BC+exosomes (BC+Exos) membrane in vitro was evaluated, and its in vitro cytotoxicity and in vivo biocompatibility were tested. The prevention effect of BC+Exos membrane on epidural fibrosis post-laminectomy in a rabbit model was investigated.
The BC+Exos membrane showed a three-dimensional network structure constituted of high-purity cellulose and moderate mechanical properties. No degeneration was observed. The BC+Exos membrane showed no cytotoxicity and displayed biocompatibility in vivo. The BC+Exos film was able to inhibit epidural fibrosis and peridural adhesions.
Based on the current findings, the BC+Exos membrane is a promising material to prevent postoperative epidural fibrosis and adhesion.
Journal Article
A new method for instant correction of numerical weather prediction products in China
by
ZHANG Lan Hui WANG Shi Gong HE Chan Sheng SHANG Ke Zheng MENG Lei LI Xu Brent M. LOFGREN
in
Correlation coefficient
,
Earth and Environmental Science
,
Earth Sciences
2015
This paper presents a new correction method, “instant correction method(ICM)”, to improve the accuracy of numerical prediction products(NPP) and provide weather variables at grid cells. The ICM makes use of the continuity in time of the forecast errors at different forecast times to improve the accuracy of large scale NPP. To apply the ICM in China, an ensemble correction scheme is designed to correct the T213 NPP(the most popular NPP in China) through different statistical methods. The corrected T213 NPP(ICM T213 NPP) are evaluated by four popular indices: Correlation coefficient, climate anomalies correlation coefficient, root-mean-square-errors(RMSE), and confidence intervals(CI). The results show that the ICM T213 NPP are more accurate than the original T213 NPP in both the training period(2003–2008) and the validation period(2009–2010). Applications in China over the past three years indicate that the ICM is simple, fast, and reliable. Because of its low computing cost, end users in need of more accurate short-range weather forecasts around China can benefit greatly from the method.
Journal Article
Preparation and characterization of hydroxyapatite/γ-Fe2O3 hybrid nanostructure
by
Chen, Kezheng
,
Xu, Lei
,
Sun, Ruixue
in
Advanced Materials
,
Chemistry and Materials Science
,
Materials Science
2013
The hybrid particles composed of hydroxyapatite (HAp) and ferrite (
γ
-Fe
2
O
3
) were synthesized by two-step precipitation method. The effect of reaction temperature on the morphology of the hybrids was also studied. The resultant hybrids were characterized by transmission electron microscopy (TEM) and X-ray diffraction analysis(XRD). It was found that
γ
-Fe
2
O
3
nanoparticles dispersed within the HAp matrix and these hybrids had a feather-like or spherical morphology when synthesized at 90 °C or room temperature, respectively. The magnetic properties of the hybrid showed good superparamagnetic feature, and they could be controlled by the external magnetic field.
Journal Article
Preparation and characterization of hydroxyapatite/gamma-Fe^sub 2^O3 hybrid nanostructure
2013
The hybrid particles composed of hydroxyapatite (HAp) and ferrite ([gamma]-Fe^sub 2^O3) were synthesized by two-step precipitation method. The effect of reaction temperature on the morphology of the hybrids was also studied. The resultant hybrids were characterized by transmission electron microscopy (TEM) and X-ray diffraction analysis(XRD). It was found that [gamma]-Fe^sub 2^O3 nanoparticles dispersed within the HAp matrix and these hybrids had a feather-like or spherical morphology when synthesized at 90 °C or room temperature, respectively. The magnetic properties of the hybrid showed good superparamagnetic feature, and they could be controlled by the external magnetic field.[PUBLICATION ABSTRACT]
Journal Article
Preparation and characterization of hydroxyapatite/ gamma -Fe sub(2) O sub(3) hybrid nanostructure
2013
The hybrid particles composed of hydroxyapatite (HAp) and ferrite ( gamma -Fe sub(2)O sub(3)) were synthesized by two-step precipitation method. The effect of reaction temperature on the morphology of the hybrids was also studied. The resultant hybrids were characterized by transmission electron microscopy (TEM) and X-ray diffraction analysis(XRD). It was found that gamma -Fe sub(2)O sub(3) nanoparticles dispersed within the HAp matrix and these hybrids had a feather-like or spherical morphology when synthesized at 90 degree C or room temperature, respectively. The magnetic properties of the hybrid showed good superparamagnetic feature, and they could be controlled by the external magnetic field.
Journal Article