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The self-made polycarboxylic acid water reducer was used as a dispersant to investigate its influence on the dispersion property of new functional material graphene slurry. The dispersion technology in the preparation process of new functional material and the influence of the dosage of new functional material on the performance of concrete were studied. The results showed that the self-made polycarboxylic acid water reducer as a dispersant can improve the dispersibility of the new functional material graphene in water. When the ultrasonic dispersion time is 40min, it can be used to discharge bubbles in the graphene dispersion solution and improve the strength of concrete. By means of manual mixing, the concrete containing the dispersible liquid of the new functional material has less slump and less expansion loss at 1h, and higher compressive strength at 3 d, 7 d, and 28 d. The 7 d and 28 d compressive strength of concrete can be significantly improved when the content of new functional material graphene dispersion is 0 ∼ 0.23 %, and the optimal content of graphene dispersion is 0.05 %.

Non-small cell lung cancer (NSCLC) harboring MET exon 14 skipping mutations or MET overexpression/amplification typically exhibits highly proliferative and invasive phenotypes and is a significant threat to human health. Although tyrosine kinase inhibitors targeting MET have been approved for clinical use over the past decade, treatment for MET-aberrant patients still face large unmet needs with issues such as limited response duration and drug resistance, low response rates and need for effective combination therapies, differential treatment response in patient subgroups, as well as clinical dose optimization and possibility of personalized medicine. To address these challenges, we developed a quantitative systems pharmacology (QSP) model that mechanistically recapitulated the complex regulation within the MET signaling network and integrated multiscale preclinical-clinical datasets for a total of 16 candidate drugs to drive translational drug research. This comprehensive QSP model framework, upon rigorous stepwise calibration and validation, has enabled high-throughput clinical efficacy analysis of different emerging combination therapies across varying dose ranges, offering crucial insights for drug development and dose optimization in MET-aberrant patients. We further integrated cancer patient-derived organoid (PDO) data on drug sensitivity into the QSP framework and explored the translational utility of this hybrid drug analysis paradigm towards the design of optimal personalized treatment regimens for 5 NSCLC patients harboring MET amplification. To our knowledge, our work is the first multiscale QSP investigation of MET dysregulation for translational cancer drug research, and by integrating QSP model analyses with PDO data it has opened up a new route to facilitate future cancer personalized medicine.

This dissertation reflects on my research outcomes since beginning my doctoral degree in Music Composition at the University of Texas at Austin. My focus has been on sound exploration, examining the interpretation and utilization of sound elements, and understanding the interactions and structures underlying sound. A timbre-oriented analysis is provided for five represented works I composed over the past four years, with a particular emphasis on my dissertation project, Me and My Shadow, a concerto for Chinese sheng and Western Ensemble. Additionally, this paper concludes with a discourse in which I share my reflections and observations on cultural confluence and its impact on my creative work and personal identity as a composer.

Polycarboxylate ether (PCE) with different main chain structures was prepared by aqueous solution free radical polymerization using unsaturated acids containing sulfonic acid groups, acrylamide groups, and carboxyl groups and isoprenyl polyoxyethylene ether (IPEG). The molecular structure was characterized by infrared spectroscopy and gel chromatography, while adsorption, dispersion, and hydration properties were studied using a total organic carbon analyzer, rheometer, and isothermal microcalorimeter, respectively. The results show that the adsorption process of PCE on cement particles is spontaneous physical adsorption. The adsorption forces are mainly electrostatic interaction, and hydrogen bonding. The introduction of sulfonic acid groups and polycarboxylic acid groups reduces the initial adsorption amount of PCE but can accelerate the adsorption rate of PCE on cement and increase the adsorption amount at the adsorption equilibrium. The introduction of acrylamide groups in the PCE main chain is beneficial to the initial dispersion of PCE and can reduce the plastic viscosity of cement slurry. PCE can delay the hydration of cement. The introduction of acrylamide groups and dicarboxylic acid groups in the PCE main chain helps prolong the induction period of cement hydration, while the introduction of sulfonic acid groups is not conducive to its retarding effect.

Four different types of polycarboxylic superplasticizers were synthesized by using different macromonomers, and then the molecular behavior of GPC, infrared, nuclear magnetic, cement hydration heat and micromorphology were characterized. The results showed that different types of PCEs have different molecular behaviors. The research showed that the molecular weight and molecular weight distribution of PCE1 were the smallest, and these four different types of PCEs have better molecular weight and molecular weight distribution. The infrared spectra of the four PCEs were not much different. However, by 1H NMR, the macromonomer used in PCE1 when synthesised was MPEG. The macromonomer used in PCE2 and PCE4 when synthesised were TPEG, and the macro monomer used in PCE3 was HPEG. Cement hydration heat and scanning electron microscope data showed that PCE4 has the better early strength.

This article disclosed to design a series of polycarboxylate superplasiticizer (PHC) by free radical polymerization. The PEO grafting side chain desity and main chain compositon of PCE greatly influenced the concrete performance. The PEO long side chain of PCE can produces steric hindrance effect in concrete to provide the flowability. The functional monomer DAC and AMPS incorporated into the main chain can improve the compressive strength. The suitable water dosage in the PHC mix proportion is 145 kg/m3 and 150 kg/m3.

In this paper, the hydration heat and hydration temperature-time curves of different proportions of cement, fly ash, mineral power, and fly ash and mineral power at different ages were studied. The results showed that compared with cement alone, fly ash and the heat of hydration of cement at different ages had been reduced, and the maximum temperature had been reduced to varying degrees. The maximum temperature time had been advanced compared to cement, and the reduction of the hydration heat of cement by pulverized coal was higher than that of pulverized coal. Ash reduced the heat of cement hydration. When cement was replaced by fly ash and mineral power in different proportions, the heat of hydration was also reduced, but the reduction was disproportionate. As the blending ratio increased, the degree of hydration of the cement decreased and the maximum temperature decreased. The reduction of hydration heat of fly ash was better than the end of the initial period, but the reduction of heat of hydration by mineral powder was not very obvious, but it can slow down the heat release rate of hydration heat significantly.

The effects of the type of mobile phase and its flow rate, column temperature, and detector temperature on the chromatographic peak separation and molecular weight test results of polycarboxylate water-reducer were studied. A method for measuring the molecular weight of polycarboxylic acid water-reducing agent by gel chromatography was established, and the accuracy of the method was verified by using two dextran standard substances of standard sample 2, standard sample 3. The results show that a 0.1 mol/L sodium nitrate solution containing 0.05% sodium azide should be selected as the mobile phase, the flow rate is 0.8-0.9 mL/min, and the column temperature and the detector temperature are 35-40 °C. It has been verified that the relative errors of the molecular weight test results of standard sample 2 and standard sample 3 are all less than 5%, and the MP, Mn, and Mw values measured by this measurement method are close to the true values.

In this paper, an early-strength polycarboxylate superplasticizer ZQ-PC for precast concrete was prepared by introducing an alcohol amine small monomer DAC into a traditional polycarboxylate superplasticizer. The prepared sample ZQ-PC, the commercially available sample SL-1, and the blank sample were selected for comparison test. The peak time and peak height of the cement hydration heat added to the cement mortar of the three groups of samples and the scanning electron microscope observation microscopic images after 3 days of curing in the concrete samples were tested. The results show that the addition of ZQ-PC can significantly accelerate the hydration time of the cement and accelerate the formation of C-S-H gel in concrete.