Explore the vast range of titles available.

Electrospun porous nanofibers have gained a lot of interest recently in various fields because of their adjustable porous structure, high specific surface area, and large number of active sites, which can further enhance the performance of materials. This paper provides an overview of the common polymers, preparation, and applications of electrospun porous nanofibers. Firstly, the polymers commonly used to construct porous structures and the main pore-forming methods in porous nanofibers by electrospinning, namely the template method and phase separation method, are introduced. Secondly, recent applications of electrospun porous nanofibers in air purification, water treatment, energy storage, biomedicine, food packaging, sensor, sound and wave absorption, flame retardant, and heat insulation are reviewed. Finally, the challenges and possible research directions for the future study of electrospun porous nanofibers are discussed.

Reliable prediction of remaining useful life (RUL) plays an indispensable role in prognostics and health management (PHM) by reason of the increasing safety requirements of industrial equipment. Meanwhile, data-driven methods in RUL prognostics have attracted widespread interest. Deep learning as a promising data-driven method has been developed to predict RUL due to its ability to deal with abundant complex data. In this paper, a novel scheme based on a health indicator (HI) and a hybrid deep neural network (DNN) model is proposed to predict RUL by analyzing equipment degradation. Explicitly, HI obtained by polynomial regression is combined with a convolutional neural network (CNN) and long short-term memory (LSTM) neural network to extract spatial and temporal features for efficacious prognostics. More specifically, valid data selected from the raw sensor data are transformed into a one-dimensional HI at first. Next, both the preselected data and HI are sequentially fed into the CNN layer and LSTM layer in order to extract high-level spatial features and long-term temporal dependency features. Furthermore, a fully connected neural network is employed to achieve a regression model of RUL prognostics. Lastly, validated with the aid of numerical and graphic results by an equipment RUL dataset from the Commercial Modular Aero-Propulsion System Simulation(C-MAPSS), the proposed scheme turns out to be superior to four existing models regarding accuracy and effectiveness.

INTRODUCTION:Covert/minimal hepatic encephalopathy (C/MHE) is the mildest form of hepatic encephalopathy (HE), but it is closely related to the quality of life and prognosis of patients with cirrhosis. Currently, the epidemiological data of C/MHE have not been well described.METHODS:We searched the PubMed, Embase, and Cochrane Library databases for relevant articles. We performed a random-effects meta-analysis of proportions to estimate the pooled prevalence of C/MHE in patients with cirrhosis. We also examined potential risk factors for C/MHE by comparing characteristics of patients with and without C/MHE.RESULTS:Finally, a total of 101 studies were included. The prevalence of C/MHE was 40.9% (95% confidence interval, 38.3%-43.5%) among patients with cirrhosis worldwide. The pooled C/MHE prevalence was 39.9% (95% confidence interval 36.7%-43.1%) based on studies using the psychometric HE score as a diagnostic tool. Meta-regression models showed that geographic region, sample size, mean age, sex ratio, and Child-Pugh classification were influencing factors for the heterogeneity of C/MHE prevalence. The presence of C/MHE was found to be associated with various factors including age, level of education, alcoholic etiology, Child-Pugh classification, MELD score, history of overt HE, presence of other complications, and laboratory tests related to impaired liver function.DISCUSSION:This study reports detailed data on the prevalence of C/MHE as well as clinical features associated with C/MHE, suggesting that C/MHE is one of the most common complications of liver cirrhosis.

In traditional pharmaceutics, drug–crystalline nanoparticles and drug–polymer composites are frequently explored for their ability to modify drug release profiles. In this study, a novel sort of hybrid with a coating of acyclovir crystalline nanoparticles on acyclovir-polyacrylonitrile composites was fabricated using modified, coaxial electrospinning processes. The developed acyclovir-polyacrylonitrile at the acyclovir nanohybrids was loaded with various amounts of acyclovir, which could be realized simply by adjusting the sheath fluid flow rates. Compared with the electrospun composite nanofibers from a single-fluid blending process, the nanohybrids showed advantages of modifying the acyclovir release profiles in the following aspects: (1) the initial release amount was more accurately and intentionally controlled; (2) the later sustained release was nearer to a zero-order kinetic process; and (3) the release amounts at different stages could be easily allocated by the sheath fluid flow rate. X-ray diffraction results verified that the acyclovir nanoparticles were in a crystalline state, and Fourier-transform infrared spectra verified that the drug acyclovir and the polymer polyacrylonitrile had a good compatibility. The protocols reported here could pave the way for developing new types of functional nanostructures.

Since the third scientific and technological revolution, electronic information technology has developed rapidly, and piezoelectric materials that can convert mechanical energy into electrical energy have become a research hotspot. Among them, piezoelectric polymers are widely used in various fields such as water treatment, biomedicine, and flexible sensors due to their good flexibility and weak toxicity. However, compared with ceramic piezoelectric materials, the piezoelectric properties of polymers are poor, so it is very important to improve the piezoelectric properties of polymers. Electrospinning technology can improve the piezoelectric properties of piezoelectric polymers by adjusting electrospinning parameters to control the piezoelectrically active phase transition of polymers. In addition, the prepared nanofibrous membrane is also a good substrate for supporting piezoelectric functional particles, which can also effectively improve the piezoelectric properties of polymers by doping particles. This paper reviews the piezoelectric properties of various electrospun piezoelectric polymer membranes, especially polyvinylidene fluoride (PVDF)-based electrospun nanofibrous membranes (NFs). Additionally, this paper introduces the various methods for increasing piezoelectric properties from the perspective of structure and species. Finally, the applications of NFs in the fields of biology, energy, and photocatalysis are discussed, and the future research directions and development are prospected.

Background In recent years, submucosal tunneling endoscopic resection (STER) has emerged as a novel therapeutic endoscopic technique for upper gastrointestinal submucosal tumors (SMTs). The aim of this study was to evaluate the safety and efficacy of STER for upper gastrointestinal SMTs. Methods A systematic search of both English and Chinese databases was performed until November 15, 2015. Complete resection and en bloc resection rates were considered the primary outcome measures. Prevalence of complications was considered the secondary outcome measure. A random-effects model was used to generate conservative estimates of the prevalence of the main outcome variables. All data analyses were performed using Meta-Analyst software (version beta 3.13). Results A total of 28 studies were included in the final meta-analysis. The pooled complete resection and en bloc resection rates were 97.5 % (95 % CI 96.0–98.5 %) and 94.6 % (95 % CI 91.5–96.7 %), respectively. The common complications associated with STER were air leakage symptoms and perforation. The pooled prevalence of air leakage symptoms was 14.8 % (95 % CI 10.5–20.5 %) for subcutaneous emphysema and pneumomediastinum, 6.1 % (95 % CI 4.0–9.0 %) for pneumothorax and 6.8 % (95 % CI 4.7–9.6 %) for pneumoperitoneum. Additionally, the pooled prevalence of perforation was 5.6 % (95 % CI 3.7–8.2 %). Only a few cases of bleeding were reported in two studies. Conclusions STER is a highly feasible and safe treatment option for upper gastrointestinal SMTs.

Crop roots are colonized by large numbers of microorganisms, collectively known as the root-microbiome, which modulate plant growth, development and contribute to elemental nutrient uptake. In conditions of nitrogen limitation, the over-expressed Calcineurin B-like interacting protein kinase 2 ( OsCIPK2 ) gene with root-specific promoter (RC) has been shown to enhance growth and nitrogen uptake in rice. Analysis of root-associated bacteria through high-throughput sequencing revealed that OsCIPK2 has a significant impact on the diversity of the root microbial community under low nitrogen stress. The quantification of nifH gene expression demonstrated a significant enhancement in nitrogen-fixing capabilities in the roots of RC transgenetic rice. Synthetic microbial communities (SynCom) consisting of six nitrogen-fixing bacterial strains were observed to be enriched in the roots of RC, leading to a substantial improvement in rice growth and nitrogen uptake in nitrogen-deficient soils. Forty and twenty-three metabolites exhibiting differential abundance were identified in the roots and rhizosphere soils of RC transgenic rice compared to wild-type (WT) rice. These findings suggest that OSCIPK2 plays a role in restructuring the microbial community in the roots through the regulation of metabolite synthesis and secretion. Further experiments involving the exogenous addition of citric acid revealed that an optimal concentration of this compound facilitated the growth of nitrogen-fixing bacteria and substantially augmented their population in the soil, highlighting the importance of citric acid in promoting nitrogen fixation under conditions of low nitrogen availability. These findings suggest that OsCIPK2 plays a role in enhancing nitrogen uptake by rice plants from the soil by influencing the assembly of root microbial communities, thereby offering valuable insights for enhancing nitrogen utilization in rice cultivation.

This study aimed to study the diagnostic value of targeted next-generation sequencing (NGS) in limb-girdle muscular dystrophies (LGMDs), and investigate the mutational spectrum of Chinese LGMD patients. We performed targeted NGS covering 420 genes in 180 patients who were consecutively suspected of LGMDs and underwent muscle biopsies from January 2013 to May 2015. The association between genotype and myopathological profiles was analyzed in the genetically confirmed LGMD patients. With targeted NGS, one or more rare variants were detected in 138 patients, of whom 113 had causative mutations, 10 sporadic patients had one pathogenic heterozygous mutation related to a recessive pattern of LGMDs, and 15 had variants of uncertain significance. No disease-causing mutation was found in the remaining 42 patients. Combined with the myopathological findings, we achieved a positive genetic diagnostic rate as 68.3% (123/180). Totally 105 patients were diagnosed as LGMDs with genetic basis. Among these 105 patients, the most common subtypes were LGMD2B in 52 (49.5%), LGMD2A in 26 (24.8%) and LGMD 2D in eight (7.6%), followed by LGMD1B in seven (6.7%), LGMD1E in four (3.8%), LGMD2I in three (2.9%), and LGMD2E, 2F, 2H, 2K, 2L in one patient (1.0%), respectively. Although some characteristic pathological changes may suggest certain LGMD subtypes, both heterogeneous findings in a certain subtype and overlapping presentations among different subtypes were not uncommon. The application of NGS, together with thorough clinical and myopathological evaluation, can substantially improve the molecular diagnostic rate in LGMDs. Confirming the genetic diagnosis in LGMD patients can help improve our understanding of their myopathological changes.

The excessive use of ciprofloxacin, an antibiotic, has led to environmental challenges such as drug resistance and severe water pollution, necessitating effective mitigation strategies. Piezo-photocatalytic technology offers a sustainable solution. In this study, BiVO4, recognized for its exceptional visible light absorption and conductivity, was embedded within polyvinylidene fluoride (PVDF) nanofibers to address issues of secondary water pollution and enhance material recovery. The addition of peroxymonosulfate (PMS) further improved the degradation process by generating highly reactive sulfate radicals (•SO4−), which acted synergistically with piezoelectric effects to enhance pollutant breakdown. Under the combined effects of stir, illumination, and PMS activation, BiVO4 achieved a 40% higher ciprofloxacin degradation efficiency compared to mechanical stir alone. This improvement is attributed to the generation of polarization charges at both ends of the material and the •SO4−, which promoted efficient electron-hole separation and oxidative degradation. This study introduces a novel approach to piezo-photocatalytic water treatment using flexible BiVO4 membrane materials with PMS enhancement.

The invasive golden apple snail Pomacea canaliculata has a strong reproductive capacity and has rapidly spread in Asian countries. Current control methods include physical, chemical, and biological approaches, but there has been limited research on the control of P. canaliculata in its different life stages. This study assessed the effectiveness of using giant river prawns Macrobrachium rosenbergii in controlling juveniles of P. canaliculata through a controlled indoor experiment. The density, size, and dispersal range of recently hatched juvenile snails were significantly lower among those kept with prawns than those kept without prawns, indicating a control effect of M. rosenbergii at least on P. canaliculata juveniles. Furthermore, the study speculates on the potential application of M. rosenbergii in the context of a rice–prawn symbiotic system of ecological farming to control invasive P. canaliculata. In terms of effectiveness and safety, its application might lead to a win-win situation for both rice-farm profits and the ecological benefits of invasive species control.