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Background Retina degenerative disorders represent the primary cause of blindness in UK and in the developed world. In particular, Age Related Macular Degeneration (AMD) and Retina Pigmentosa (RP) diseases are of interest to this study. We have therefore created new image processing algorithms for enhancing the visual scenes for them. Methods In this paper we present three novel image enhancement techniques aimed at enhancing the remaining visual information for patients suffering from retina dystrophies. Currently, the only effective way to test novel technology for visual enhancement is to undergo testing on large numbers of patients. To test our techniques, we have therefore built a retinal image processing model and compared the results to data from patient testing. In particular we focus on the ability of our image processing techniques to achieve improved face detection and enhanced edge perception. Results Results from our model are compared to actual data obtained from testing the performance of these algorithms on 27 patients with an average visual acuity of 0.63 and an average contrast sensitivity of 1.22. Results show that Tinted Reduced Outlined Nature (TRON) and Edge Overlaying algorithms are most beneficial for dynamic scenes such as motion detection. Image Cartoonization was most beneficial for spatial feature detection such as face detection. Patient's stated that they would most like to see Cartoonized images for use in daily life. Conclusions Results obtained from our retinal model and from patients show that there is potential for these image processing techniques to improve visual function amongst the visually impaired community. In addition our methodology using face detection and efficiency of perceived edges in determining potential benefit derived from different image enhancement algorithms could also prove to be useful in quantitatively assessing algorithms in future studies.

This is a case report of a 93-year-old Caucasian female who presented with severe dysphagia and weight loss. She was found to have both a large Zenker's diverticulum and a massive paraesophageal hernia with a complete intrathoracic stomach. The minimally invasive management and treatment of Zenker's diverticulum and paraesophageal hernia have both been well described on their own. However, we chose to report this case because little has actually been reported about the concurrent management of both clinical conditions. Said conditions were mutually associated with each other, and deciding which condition to treat first, as well as the appropriate timing of this management, all was carefully considered in the proper management of this patient.

Purpose Soft tissue sarcomas (STS) are a heterogeneous group of rare mesenchymal neoplasms, accounting for < 1% of all newly diagnosed malignancies. These tumors can occur in almost any anatomic site though they most frequently occur in the extremities. The objective of the study was to describe the epidemiology, treatment paradigm, and real-world outcomes in the clinical management of metastatic STS (mSTS) in the Middle East and North Africa (MEA) region. Methods MOON was an observational, multicenter, retrospective patient chart review study which included 200 patients with mSTS in the final analysis. The primary objective of the study is exploratory, so it is presented using descriptive statistics. Results At the time of presentation, 62.0% patients had metastatic disease, 27.5% had received only their primary diagnosis and 10.0% had experienced a local recurrence. The most frequent STS localizations were lower extremities (74%), trunk (28.5%) and upper extremities (10.5%). Primary tumor was staged as T2b in the majority (60%) of patients. Surgical treatment was performed most often for the primary disease, whereas radiation therapy and chemotherapy were predominantly administered with palliative intent. A total of 38 patients received treatment with pazopanib. Thirteen adverse events (AEs) were attributed to pazopanib in eight patients. Conclusion Adult patients treated for STS have al most equal gender ratio and mostly are middle aged. The majority of patients have metastatic disease and disease progression, and half of the patients died from the disease during the period of evaluation. This study obtained real-life data on the clinical management of STS in MEA countries which could be shared with the medical community.

Objectives: It was the aim of this study to assess the attitudes of doctors, medical students, lawyers, parliament members and parents of thalassemic children towards genetic diagnosis in Pakistan. Study Design: A cross-sectional descriptive survey was conducted among representative samples. Results: Five hundred and seventy doctors, 49 lawyers, 178 medical students, 89 parents of thalassemic children and 16 members of parliament (MPs) were included in the survey. The groups showed considerable difference in their attitudes towards different aspects of the issue. A large proportion (88.5%) agreed to the idea of genetic diagnostic screening, especially the parents of thalassemic patients. Premarital carrier screening was favored by 77% of the respondents. Prenatal screening was most favored by the parents of thalassemic children (94.4%). Likewise, a majority of parents of thalassemic children were in favor of abortion in case of an affected fetus. Genetic self-screening was also favored most by the parents of thalassemic patients (78.2%). Only 24% of the doctors favored making genetic screening mandatory, whereas 63% of the parents agreed to the idea. Conclusion: Attitudes regarding genetic diagnosis are markedly different among various societal groups in Pakistan. The parents of the affected children strongly favor genetic screening as does the medical community, though not as strongly as the parents. The legislative groups, particularly the MPs, are reserved in their support. Genetic diagnosis can help decrease the disease burden in the future. However, it raises a number of ethical issues, which need to be addressed. It is important to educate the population about potential benefits as well as ethical dilemmas involved so that the general public is able to make the right decisions for themselves and their families. Copyright © 2007 S. Karger AG, Basel

Soil management practices are used to enhance soil organic carbon, fertility, and crop productivity around the world. However, accurate information about the appropriate amount of straw incorporation is not available, because it is generally believed that at least 30% of the soil surface should be covered by straw, which is not implemented in all field environments. Therefore, a two-year (2016–2017) field experiment was conducted to investigate the impact of different percentages of straw incorporation and tillage methods, i.e., reduced tillage (RT) and conventional tillage (CT), on crop yield, soil organic carbon (SOC), total nitrogen (TN), and soil carbon storage (SCS) in rice–wheat cropping systems, under eight treatments. The experimental results showed that the greatest reduction in soil dry bulk density ( ρ b ) was found under CT with 100% straw coverage (9.79%), whereas the least reduction occurred under CT with no straw (1.31%). The mean TN concentration, soil organic matter (SOM), and soil carbon storage (SCS) were significantly higher by 0.98 g/kg, 17.07%, and 14.20%, respectively, under reduced tillage with 60% straw incorporation (RTsi60) compared with all other treatments. Our findings demonstrate that the incorporated wheat residues resulted in the highest rice production (7.95–8.63 t/ha) under RTsi60. We recommend the adoption of reduced tillage with 60% straw incorporation to increase rice yield, improve soil structure, and enhance TN, SOM, and SCS in paddy soil under rice-wheat rotation fields for agricultural sustainability.

Salinity and water stress are serious environmental issues that reduced crop production worldwide. The current research was initiated (2012) in the wirehouse of the Institute of Soil and Environmental Sciences, University of Agriculture, Faisalabad, Pakistan to investigate the growth, stress tolerance, and physiological responses of guava to salinity and water shortage. Guava was grown for one year in pots containing soil with Eight treatments (control, 10 dS m −1 , 20 dS m −1 , 40 dS m −1 , control + water stress (WS), 10 dS m −1  + WS, 20 dS m −1  + WS, 40 dS m −1  + WS) in a completely randomized design. The results indicated that plant growth, stress tolerance, and physiological parameters declined at higher salinity and water stress and could not survive at 40 dS m −1 . The 20 dS m −1  + WS caused a > 70% decline in dry weights of shoot and root regarding control. Similarly, the highest decrease in stress tolerance was noticed in 20 dS m −1  + WS followed by the 20 dS m −1 treatment than control. Our findings validated that guava can be cultivated on soils having salinity ≤ 10 dS m −1 but it could not be cultivated on soils having salinity ≥ 20 dS m −1 with limited water supply.

Precision agriculture has revolutionized crop management and agricultural production, with LiDAR technology attracting significant interest among various technological advancements. This extensive review examines the various applications of LiDAR in precision agriculture, with a particular emphasis on its function in crop cultivation and harvests. The introduction provides an overview of precision agriculture, highlighting the need for effective agricultural management and the growing significance of LiDAR technology. The prospective advantages of LiDAR for increasing productivity, optimizing resource utilization, managing crop diseases and pesticides, and reducing environmental impact are discussed. The introduction comprehensively covers LiDAR technology in precision agriculture, detailing airborne, terrestrial, and mobile systems along with their specialized applications in the field. After that, the paper reviews the several uses of LiDAR in agricultural cultivation, including crop growth and yield estimate, disease detection, weed control, and plant health evaluation. The use of LiDAR for soil analysis and management, including soil mapping and categorization and the measurement of moisture content and nutrient levels, is reviewed. Additionally, the article examines how LiDAR is used for harvesting crops, including its use in autonomous harvesting systems, post-harvest quality evaluation, and the prediction of crop maturity and yield. Future perspectives, emergent trends, and innovative developments in LiDAR technology for precision agriculture are discussed, along with the critical challenges and research gaps that must be filled. The review concludes by emphasizing potential solutions and future directions for maximizing LiDAR’s potential in precision agriculture. This in-depth review of the uses of LiDAR gives helpful insights for academics, practitioners, and stakeholders interested in using this technology for effective and environmentally friendly crop management, which will eventually contribute to the development of precision agricultural methods.

Hypertension (HTN) affects over a billion people worldwide, with most cases in low- and middle-income countries (LMICs) where awareness and control remain low. In Pakistan, general practitioners (GPs) are usually the initial contact for hypertensive patients. Through the Train the Trainer (TTT) initiative, a group of consultant cardiologists were trained as master trainers to conduct training for GPs across Pakistan. This study aimed to assess the effectiveness of the TTT initiative regarding knowledge of GPs about the diagnosis and management of HTN. This study included 540 GPs from all over Pakistan. Participants attended HTN training workshops run by Master Trainers under the TTT model and completed a structured online questionnaire in relation to knowledge of HTN before and 1-3 months after training. Knowledge scores were derived from correct responses for 19 items. Pre-training GPs demonstrated low HTN knowledge scores with a median of 26.3 [IQR: 15.8-36.8] and 92% scoring less than 50. In contrast, post-training medians increased significantly to 42.1 [IQR: 31.6-63.2], with 38.5% of GPs achieving moderate or high knowledge scores ≥50 (p < 0.001). Overall, gains were observed across all demographic groups; significant improvement was observed among female and younger GPs. The TTT initiative effectively improved knowledge in both the diagnosis and management of hypertension among GPs, thus standing to potentially improve the current gaps in HTN care in many LMICs through similar models. Further studies are warranted to document the long-term clinical impact of this kind of training on patient outcomes and hypertension control.

In this study, a high-Q circular substrate-integrated waveguide (SIW) cavity resonator is proposed as a non-contact and non-invasive radio frequency (RF) sensor for chemical sensing applications. The design of the structure utilizes SIW technology along with a circular shape to achieve a high unloaded Q factor, which is one of the important requirements for RF sensors. The resonant frequency of the proposed circular SIW cavity sensor changes when a liquid material or a chemical (microliters) is inserted in the sensitive area of the structure. The sensing of liquid materials with different permittivities is accomplished via the perturbation of the electric fields in the SIW configuration. When a microwell that is 4 mm in radius is installed vertically through the center of the bare circular SIW cavity, the operating frequency varies from 5.26 to 5.34 GHz. Similarly, when the microwell contains ethanol, the frequency shifts from 5.26 to 5.18 GHz, and the amplitude of reflection coefficient is shifted from −29 dB to −17 dB; when the microwell contains mixing deionized (DI)-water, the frequency moves from 5.26 to 4.98 GHz (which is also 0% Ethanol in our study), and the amplitude of reflection coefficient is shifted from −29 dB to −8 dB. A high unloaded Q factor is maintained throughout all experimental results. To demonstrate our idea, different concentrations of ethanol are tested and recorded. The experimental validation yields a close agreement between the simulations and the measurements.