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Paradigm shifts throughout the history of microbiology have typically been ignored, or met with skepticism and resistance, by the scientific community. This has been especially true in the field of virology, where the discovery of a “contagium vivum fluidum”, or infectious fluid remaining after excluding bacteria by filtration, was initially ignored because it did not coincide with the established view of microorganisms. Subsequent studies on such infectious agents, eventually termed “viruses”, were met with skepticism. However, after an abundance of proof accumulated, viruses were eventually acknowledged as defined microbiological entities. Next, the proposed role of viruses in oncogenesis in animals was disputed, as was the unique mechanism of genome replication by reverse transcription of RNA by the retroviruses. This same pattern of skepticism holds true for the prediction of the existence of retroviral “antisense” transcripts and genes. From the time of their discovery, it was thought that retroviruses encoded proteins on only one strand of proviral DNA. However, in 1988, it was predicted that human immunodeficiency virus type 1 (HIV-1), and other retroviruses, express an antisense protein encoded on the DNA strand opposite that encoding the known viral proteins. Confirmation came quickly with the characterization of the antisense protein, HBZ, of the human T-cell leukemia virus type 1 (HTLV-1), and the finding that both the protein and its antisense mRNA transcript play key roles in viral replication and pathogenesis. However, acceptance of the existence, and potential importance, of a corresponding antisense transcript and protein (ASP) in HIV-1 infection and pathogenesis has lagged, despite gradually accumulating theoretical and experimental evidence. The most striking theoretical evidence is the finding that asp is highly conserved in group M viruses and correlates exclusively with subtypes, or clades, responsible for the AIDS pandemic. This review outlines the history of the major shifts in thought pertaining to the nature and characteristics of viruses, and in particular retroviruses, and details the development of the hypothesis that retroviral antisense transcripts and genes exist. We conclude that there is a need to accelerate studies on ASP, and its transcript(s), with the view that both may be important, and overlooked, targets in anti-HIV therapeutic and vaccine strategies.

\"Innovation is essential for businesses to survive in the long run, but there are no one-size-fits-all strategies for innovating successfully. A firm's specific business environment will determine what works and what does not work. Based on a global survey of innovative firms and on 50 in-depth case studies, Innovation Reinvented identifies six patterns or 'games' of innovation, each commanding best-of-class strategies and best practices. Examining recognized innovative companies - from Apple and Intel in the technology area to Proctor & Gamble and Clorox in mature markets - this book dispels the notion of innovation as a 'one-size fits all' or necessarily radical process. As Roger Miller and Marcel Cمotâe demonstrate, the vast majority of innovations result from improvements in product features or business processes. Innovation Reinvented provides a unique framework for entrepreneurs and senior executives to identify the game(s) in which a business is involved, and which approaches are best-suited to win by competing on innovation.\"--Publisher's website.

Electric vehicle sales are growing globally in response to the move towards a greener environment and a reduction in greenhouse gas emissions. As in any machine, grease lubricants will play a significant role in the component life of these new power plants and drivetrains. In this paper, the role of grease lubrication in electric vehicles (EVs) and hybrid vehicles (HVs) will be discussed in terms of performance requirements. Comparisons of grease lubrication in EVs and HVs for performance requirements to current internal combustion engines (ICEs) will be reviewed to contrast the major differences under different operating conditions. The operating conditions for grease lubrication in these EVs and HVs are demanding. Greases formulated and manufactured to meet specific performance specifications in EVs and HVs, which will operate within these specific electrification components, will be reviewed. Specifically, the thermal and electrified effects from the higher operating temperatures and electromagnetic fields on lubricant degradation, rheology, elastomer compatibility, and corrosion protection of the grease need to be evaluated to accurately meet the performance requirements for EVs and HV. The major differences between EVs and conventional ICEVs can be grouped into the following technical areas: energy efficiency, noise, vibration, and harshness (NVH), the presence of electrical current and electromagnetic fields from electric modules, sensors and circuits, and bearing lubrication. Additional considerations include thermal heat transfer, seals, corrosion protection, and materials’ compatibility. The authors will review the future development trends of EVs/HVs on driveline lubrication and thermal management requirements. The future development of electric vehicles will globally influence the selection and development of gear oils, coolants, and greases as they will be in contact with electric modules, sensors, and circuits and will be affected by electrical current and electromagnetic fields. The increasing presence of electrical parts in EVs/HVs will demand the corrosion protection of bearings and other remaining mechanical components. Thus, it is imperative that specialized greases should be explored for specific applications in EVs/HVs to ensure maximum protection from friction, wear, and corrosion to guarantee the longevity of the operating automobile. Low-viscosity lubricants and greases will be used in EVs to achieve improvements in energy efficiency. However, low-viscosity fluids reduce the film thickness in the driveline application. This reduced film thickness increases the operating temperature and reduces the calculated fatigue life of the bearings. Bearing components for EVs/HVs will be even more crucial as original equipment manufacturers (OEMs) specify these low-viscosity fluids. The application of premium bearing components using low-viscosity grease will leverage materials, bearing geometries, and surface topography to combat the impact of low-viscosity lubricants. In addition, EVs and HVs will create their own NVH challenges. Wind and road noise are more prominent, with no masking noise from the ICE. Increasing comfort, quality, and reliability issues will be more complicated with the introduction of new electrified powertrain and E-driveline subsystems. This paper elaborates on the current development trends and industrial test standard for the specified grease used for electrical/hybrid driveline lubrication.

The confinement boundaries of spent nuclear fuel (SNF) canisters are typically fusion welded. Welded microstructures, strain hardening, and residual stresses combined with a chemically aggressive, chloride-rich environment led to concerns that the welded canister may be susceptible to chloride-induced stress corrosion cracking (CISCC). A comprehensive understanding of the modification of stainless steel (SS) metallurgical and mechanical properties by fusion welding could accelerate the predictive analysis of CISCC susceptibility. This paper describes a submerged arc welding (SAW) procedure that was developed and qualified on 12.7 mm (0.5 in.) thick AISI 304/304L SS to produce joints in a way similar to actual SNF canister manufacturing. This procedure has the potential to reduce the production cost and weld CISCC susceptibility by using fewer welding passes and lower heat input than current industrial applications. Global and local mechanical behaviors and properties, as well as residual stress distributions on the welded joint, were studied. The results indicate that hardness values in the fusion zone (FZ) and heat-affected zone (HAZ) are slightly higher than that of the base metal. Strain localization was presented in the HAZ before the tensile stress reached its maximum value, and then it shifted to the FZ. The specimen finally broke in the FZ. High tensile residual stresses exhibited in the FZ and the nearby HAZ suggest the highest CISCC-susceptible spots. The maximum tensile residual stresses were along the welding direction, indicating that if cracks occur, they would be perpendicular to the welding direction. This study involved developing and qualifying a SAW procedure for SNF canister production. The new procedure yielded cost savings (SAW working efficiency increased by about 80%), improved mechanical properties, and presented moderate residual stresses. Analysis revealed that the welded joint’s low-stress and high-stress damage assessments may be affected by shifts in the strain localization spot under loading.

Many grease-lubricated machinery components operate in wet environments, making them susceptible to water contamination. It has been reported that the presence of a mere 1% water contamination in grease reduces the life of a bearing by 90%. Yet there are only a few standards available to characterize grease performance in the presence of water, most of which are primarily qualitative, providing inconclusive information, often relative to standard samples, at a significant cost in time and materials. In this paper, a unique approach is proposed for evaluating grease capability for repelling water. The method utilizes the contact angle of a water droplet on a grease surface to quantify grease water resistance. It is hypothesized that the higher the hydrophobic nature of the grease, the greater the resistance to water and vice versa. The validation of the hypothesis is established by performing extensive contact angle measurements on seven types of commercially available greases. The efficacy of contact angle results is established by measuring the change in the yield stress values obtained using a rheometer. From the obtained results, it is shown that the proposed approach is reliable and capable of distinguishing greases as water repellent/attractive. Graphic Abstract

Many grease-lubricated machines operate in wet environments, and are vulnerable to contamination because of water exposure. Reports suggest that even the presence of 1% water in grease reduces the life of a bearing by 90%. Nevertheless, only a few qualitative tests and standards are available to characterize the water resistance properties of greases. In this paper, we propose a standard for evaluating the water resistance properties of greases by studying their hydrophobic and hydrophilic nature via a custom-designed apparatus for measuring the grease contact angle. In this approach, a water droplet is dispensed onto the surface of the grease and the contact angle of the droplet is studied. For this purpose, an apparatus was designed, built, and tested with twelve different greases. To validate the efficacy of the test method and setup, tests were performed at two different locations by independent operators. From the obtained contact angle values, the authors propose categorizing a grease’s water-resistance properties into five different grades that can be set as guidelines for the industrial user when selecting a grease for machinery operation in a wet environment. The classification of the water-repellent properties of greases, using the proposed standard is compared with existing ASTM standards used for evaluation of grease properties in the presence of water.