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The main objective of this review is to summarize the evidence on the core modelling specifications and methodology on the cost-effectiveness of TKR compared to non-surgical management. Another objective of this study is to synthesize evidence of TKR cost and compare it across countries using purchasing power parity (PPP). The electronic databases used for this review were MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), HTAIn repository, Cost effectiveness Analysis (CEA) registry, and Google Scholar. Consolidated Health Economic Evaluation Reporting Standards (CHEERS) was used to assess the validity of the methods and transparency in reporting the results. The Quality of Health Economic Studies (QHES) was used to check the quality of economic evaluation models of the studies included. The cost of TKR surgery from high income and low- or middle-income countries were extracted and converted to single USD ($) using purchasing power parities (PPP) method. Thirty-two studies were included in this review, out of which eight studies used Markov model, five used regression model, one each reported Marginal structure model, discrete simulation model, decision tree and Osteoarthritis Policy Model (OAPol) respectively to assess the cost-effectiveness of TKR. For PPP, twenty-six studies were included in the analysis of TKR cost. The average cost of TKR surgery was the lowest in developing country-India ($3457) and highest in USA ($19568). The findings of this review showed that the Markov model was most widely used in the analysis of the cost effectiveness of TKR. Our review also concluded that the cost of TKR was higher in the developed countries as compared to the developing countries.

We present a methodically devised protocol for conducting a systematic review and meta-analysis aimed at ascertaining the prevalence of BReast CAncer gene (BRCA) mutations in breast and ovarian cancer (BOC) among women in India. The review will include cross-sectional, cohort, case-series, and registry-based studies focusing on females clinically diagnosed with any stage of BOC, tested for BRCA germline mutation and undergone any form of treatment. A Cochrane literature search will be carried out to identify all the published and unpublished articles available in English from 2010 till date across various electronic databases including PubMed, Psych Info, SCI, Cochrane Central, Embase, Scopus, IND Med and Google Scholar. A step-by-step process will be followed to select all the relevant studies for final inclusion using Rayyan software. The selection process of the review will be reported based on Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA) checklist. The protocol has been registered in PROSPERO (ID: CRD42023463452). Joanna Briggs Institute Critical Appraisal Checklist will be used to evaluate the methodological quality of the included studies. The outcome measure will be the prevalence of BRCA1/2 gene mutation in this population. Meta-analysis will be performed to report the pooled prevalence along with 95% confidence interval. The results of this review study will provide valuable insights for clinicians, and policy makers, enabling them to formulate guidelines that underscore the importance of screening for BRCA mutations in cases of BOC.

Septic arthritis of the hip in late childhood leads to different sequelae. These cases are often missed and lead to various disabilities like hip subluxation, limb length discrepancy, and limping. The primary goal is always to reproduce a concentrically reduced stable hip. We are presenting a 13-year child with sequelae of septic arthritis of the hip with dislocation. The child had septic arthritis of the hip two years back. The patient had a superolateral acetabular defect and was treated with triple innominate steel osteotomy. The osteotomy increased the acetabular head coverage and gave a stable congruent hip to the child. Late childhood septic arthritis cases can produce acetabular defects without involving the femoral head leading to dislocation. Such cases can be effectively treated with triple innominate pelvic osteotomy, giving good head coverage with stable congruent hips.

Operational research (OR) in eye care within resource-constrained settings helps develop context-specific solutions to local challenges. Building OR capacity among eye care personnel enables them to independently generate evidence that drives improvements in eye care delivery. This protocol describes the extended phase of the Institutional Operational Research Capacity Building (I-ORCB) program designed to train eye care professionals in the fundamentals and applications of OR. The I-ORCB program will be conducted in collaboration with Seva Canada and the Pragyaan Sustainable Health Outcomes Foundation over 3 years (2024-2027). A total of 10 partner eye hospitals in India and Nepal will participate. The training is organized around 7 work packages covering quantitative and qualitative research methods, data management and analysis, community engagement, scientific writing, grant writing, and ethics. The program will be implemented in two sequential phases: (1) protocol development and ethics committee submission and (2) mentoring, data collection, data analysis, and manuscript preparation. Delivery will include workshops, ongoing mentorship, e-resources, and structured monitoring mechanisms. Evaluation will follow the Kirkpatrick model, and cost-effectiveness will be assessed through the change in knowledge among the participants brought about by the workshops. This program is currently in the implementation phase. As of March 2025, a total of 10 teams have been enrolled in the I-ORCB program. Data collection for program evaluation began in June 2025 and is expected to continue until late 2026. Expected results include enhanced OR competencies among hospital teams, institutional strengthening for research, development of peer-reviewed manuscripts, and improved capacity to apply OR to service delivery challenges. The results of this program are expected to be published in 2027. The I-ORCB program applies a practical, learning-by-doing approach and is grounded in the Cooke framework for research capacity building. By integrating structured mentorship, institutional ownership, and flexible virtual learning components, the program is expected to strengthen OR culture in low- and middle-income countries and improve the delivery of eye care services in South Asia.

Implementation of clinical practice guidelines (CPGs) is integral to improving the quality of stroke rehabilitation in low- and middle-income countries (LMICs). However, various barriers hinder their effective utilization. This survey aimed to identify the barriers faced by rehabilitation professionals in utilizing CPGs for post-stroke motor rehabilitation. A cross-sectional survey based on the Australian Living Guidelines for Stroke Rehabilitation was developed to identify factors that influence healthcare professionals’ adherence to clinical practice guidelines. The survey comprised 50 questions spanning five domains: demographics, work practices, rehabilitation techniques, clinical practice awareness, and CPG feasibility and implementation. A panel of 10 experts validated the questionnaire. The survey was disseminated via emails, through professional associations, and platforms such as WhatsApp, LinkedIn, and X (formerly Twitter). Quantitative analysis data were analysed using Jamovi 2.3.21. The results indicated that less experienced professionals were more likely to implement CPGs, utilize telerehabilitation, and follow transition care protocols, while experienced practitioners adhered to both CPGs and hospital guidelines and employed motor outcome measures. Identified barriers included limited awareness, insufficient training, resource constraints, and challenges related to language and cultural relevance. To enhance CPG implementation, it is necessary to develop context-specific CPGs, establish stepwise clinical protocols, integrate evidence-based practice and CPG training into university curricula, and increase awareness among policymakers and stroke survivors. Engaging diverse stakeholders—patients, caregivers, multidisciplinary teams, and policymakers—is essential to foster an enabling environment for CPG adoption and advancing stroke rehabilitation practices in LMICs.

The main objective of this review is to summarize the evidence on the core modelling specifications and methodology on the cost-effectiveness of TKR compared to non-surgical management. Another objective of this study is to synthesize evidence of TKR cost and compare it across countries using purchasing power parity (PPP). The electronic databases used for this review were MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), HTAIn repository, Cost effectiveness Analysis (CEA) registry, and Google Scholar. Consolidated Health Economic Evaluation Reporting Standards (CHEERS) was used to assess the validity of the methods and transparency in reporting the results. The Quality of Health Economic Studies (QHES) was used to check the quality of economic evaluation models of the studies included. The cost of TKR surgery from high income and low- or middle-income countries were extracted and converted to single USD ( ) using purchasing power parities (PPP) method. Thirty-two studies were included in this review, out of which eight studies used Markov model, five used regression model, one each reported Marginal structure model, discrete simulation model, decision tree and Osteoarthritis Policy Model (OAPol) respectively to assess the cost-effectiveness of TKR. For PPP, twenty-six studies were included in the analysis of TKR cost. The average cost of TKR surgery was the lowest in developing country-India ( 3457) and highest in USA (19568). The findings of this review showed that the Markov model was most widely used in the analysis of the cost effectiveness of TKR. Our review also concluded that the cost of TKR was higher in the developed countries as compared to the developing countries.

This study is an economic evaluation of total knee replacement (TKR) in comparison with non-surgical management in India. Cost-utility analysis and budget impact analysis (BIA) were conducted on individuals aged ≥ 50 years with osteoarthritis of the knee (OA knee) Kellgren-Lawrence grades 2 and 3 using a provider's perspective. Three scenarios were considered, varying the age at which TKR is administered while assuming a 20-year lifespan for the implant. A Markov model was used to determine incremental cost-effectiveness ratios (ICERs). Sensitivity analysis was conducted incorporating implant costs and other input parameters. Net quality-adjusted life-years (QALYs) gained per OA knee treated with TKR were superior when performed at the age of 50, regardless of OA severity and across all scenarios. The lowest ICER was 36,107 Indian National Rupees (INR) (USD 482.9)/QALY gained, observed at 50 years, while the highest was INR 61,363 (USD 820.72)/QALY gained at 70 years for grade-2 severity. Sensitivity analysis revealed that the ICER was most sensitive to the cost of non-surgical management, health utility values gained in an improved state, and the cost of TKR across scenarios. For the BIA in Scenario 1, with 40% coverage for TKR, costs reach INR 5013 crores (cr) (USD 670,477,060) in 2023 and INR 8444 cr (USD 1,024,628,736) in 2028 (1% of government budgets). In Scenario 2 (full coverage), costs are INR 12,532 cr (USD 1,520,683,008) (2.7%) in 2023, declining to 2.4% in 2028. In Scenario 3, covering 40% under the National Health Mission (NHM), costs vary from 17% in 2023 to 25% in 2028. This study concludes that TKR is a cost-effective treatment option compared with non-surgical management for OA knee in India, irrespective of age, implant types, and severity.

Objective This study is an economic evaluation of total knee replacement (TKR) in comparison with non-surgical management in India. Methods Cost-utility analysis and budget impact analysis (BIA) were conducted on individuals aged ≥ 50 years with osteoarthritis of the knee (OA knee) Kellgren-Lawrence grades 2 and 3 using a provider’s perspective. Three scenarios were considered, varying the age at which TKR is administered while assuming a 20-year lifespan for the implant. A Markov model was used to determine incremental cost-effectiveness ratios (ICERs). Sensitivity analysis was conducted incorporating implant costs and other input parameters. Results Net quality-adjusted life-years (QALYs) gained per OA knee treated with TKR were superior when performed at the age of 50, regardless of OA severity and across all scenarios. The lowest ICER was 36,107 Indian National Rupees (INR) (USD 482.9)/QALY gained, observed at 50 years, while the highest was INR 61,363 (USD 820.72)/QALY gained at 70 years for grade-2 severity. Sensitivity analysis revealed that the ICER was most sensitive to the cost of non-surgical management, health utility values gained in an improved state, and the cost of TKR across scenarios. For the BIA in Scenario 1, with 40% coverage for TKR, costs reach INR 5013 crores (cr) (USD 670,477,060) in 2023 and INR 8444 cr (USD 1,024,628,736) in 2028 (1% of government budgets). In Scenario 2 (full coverage), costs are INR 12,532 cr (USD 1,520,683,008) (2.7%) in 2023, declining to 2.4% in 2028. In Scenario 3, covering 40% under the National Health Mission (NHM), costs vary from 17% in 2023 to 25% in 2028. Conclusion This study concludes that TKR is a cost-effective treatment option compared with non-surgical management for OA knee in India, irrespective of age, implant types, and severity.

Despite the significant financial, social, and psychological stress associated with breast cancer treatment, evidence on the quality of life (QoL) of patients currently undergoing treatment are context specific. While most studies emphasize breast cancer survivors, very few have explored QoL during the active treatment phase in Indian settings. Understanding QoL and its influencing factors during treatment is crucial for developing effective support services and interventions to improve patient outcomes. This study investigates the impact of different treatments (radiation, chemotherapy, and hormonal therapy) on various aspects of QoL, including pain, insomnia, diarrhoea, constipation, and appetite loss. It also examines how sociodemographic and clinical characteristics affect problems caused by breast cancer or its treatment. The findings reveal that patients undergoing radiation therapy report higher levels of pain, insomnia, and diarrhoea, while those receiving chemotherapy experience more constipation and appetite loss. Additionally, patients who sleep less than eight hours have worse functional scales and report more pain, nausea/vomiting, and dyspnoea compared to those who sleep eight hours or more. These results highlight the distinct impacts of different breast cancer treatments on various aspects of patients’ QoL. Moreover, co-morbidities exacerbate specific breast cancer symptoms. Hence, the study highlights that when doctors and researchers assess patients’ outcomes and well-being during cancer treatment, they should consider both medical and social aspects to better understand their needs and improve their care. The study also underscores the need for comprehensive care that addresses these different dimensions of QoL.

Improved breast cancer treatments have increased survival rates, but prolonged and costly therapies strain survivors financially. This study addresses the dearth of research on financial difficulties among breast cancer survivors (BCS) in India. A mixed-methods study was employed; we assessed financial hardship (FH) using the Comprehensive Score for Financial Toxicity-Functional Assessment of Chronic Illness Therapy (COST-FACIT), a validated 12-item questionnaire. The minimum score represents FH (FH was categorized based on scores <27). Out of 80 surveyed BCS, 60% experienced FH and had a median age of 48 years (40.5-56.5 years). Factors such as occupation, education, income, expenditures, insurance coverage, and impact on savings exhibited significant associations with FH. With only one-third having health insurance and 43.8% self-funding treatment, this research sheds light on the urgent need for targeted support and policies to alleviate the financial burdens faced by BCS in the Indian context. Financial hardship harms the mental and physical health of BCS. Collaborative efforts among policymakers, healthcare professionals, and insurers are crucial to establishing a compassionate healthcare system that addresses both immediate health and long-term financial concerns.