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"Romain, Y, (Yves)"
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The Oxford handbook of functional data analysis
\"As technology progresses, we are able to handle larger and larger datasets. At the same time, monitoring devices such as electronic equipment and sensors (for registering images, temperature, etc.) have become more and more sophisticated. This high-tech revolution offers the opportunity to observe phenomena in an increasingly accurate way by producing statistical units sampled over a finer and finer grid, with the measurement points so close that the data can be considered as observations varying over a continuum. Such continuous (or functional) data may occur in biomechanics (e.g. human movements), chemometrics (e.g. spectrometric curves), econometrics (e.g. the stock market index), geophysics (e.g. spatio-temporal events such as El Nino or time series of satellite images), or medicine (electro-cardiograms/electro-encephalograms). It is well known that standard multivariate statistical analyses fail with functional data. However, the great potential for applications has encouraged new methodologies able to extract relevant information from functional datasets. This Handbook aims to present a state of the art exploration of this high-tech field, by gathering together most of major advances in this area. Leading international experts have contributed to this volume with each chapter giving the key original ideas and comprehensive bibliographical information. The main statistical topics (classification, inference, factor-based analysis, regression modelling, resampling methods, time series, random processes) are covered in the setting of functional data. The twin challenges of the subject are the practical issues of implementing new methodologies and the theoretical techniques needed to expand the mathematical foundations and toolbox. The volume therefore mixes practical, methodological and theoretical aspects of the subject, sometimes within the same chapter. As a consequence, this book should appeal to a wide audience of engineers, practitioners and graduate students, as well as academic researchers, not only in statistics and probability but also in the numerous related application areas\"-- Provided by publisher.
Book
Biofilms of a Bacillus subtilis Hospital Isolate Protect Staphylococcus aureus from Biocide Action
The development of a biofilm constitutes a survival strategy by providing bacteria a protective environment safe from stresses such as microbicide action and can thus lead to important health-care problems. In this study, biofilm resistance of a Bacillus subtilis strain (called hereafter ND(medical)) recently isolated from endoscope washer-disinfectors to peracetic acid was investigated and its ability to protect the pathogen Staphylococcus aureus in mixed biofilms was evaluated. Biocide action within Bacillus subtilis biofilms was visualised in real time using a non-invasive 4D confocal imaging method. The resistance of single species and mixed biofilms to peracetic acid was quantified using standard plate counting methods and their architecture was explored using confocal imaging and electronic microscopy. The results showed that the ND(medical) strain demonstrates the ability to make very large amount of biofilm together with hyper-resistance to the concentration of PAA used in many formulations (3500 ppm). Evidences strongly suggest that the enhanced resistance of the ND(medical) strain was related to the specific three-dimensional structure of the biofilm and the large amount of the extracellular matrix produced which can hinder the penetration of peracetic acid. When grown in mixed biofilm with Staphylococcus aureus, the ND(medical) strain demonstrated the ability to protect the pathogen from PAA action, thus enabling its persistence in the environment. This work points out the ability of bacteria to adapt to an extremely hostile environment, and the necessity of considering multi-organism ecosystems instead of single species model to decipher the mechanisms of biofilm resistance to antimicrobials agents.
Journal Article
The Pyrenean Platform for Observation of the Atmosphere: site, long-term dataset, and science
The Pyrenean Platform for Observation of the Atmosphere (P2OA) is a coupled plain–mountain instrumented platform in southwestern France. It is composed of two physical sites: the “Pic du Midi” mountaintop observatory (2877 m a.s.l.) and the “Centre de Recherches Atmosphériques” (600 m a.s.l). Both sites are complementarily instrumented for the monitoring of climate-relevant variables and the study of meteorological processes in a mountainous region. The scientific topics covered by P2OA include surface–atmosphere interactions in heterogeneous landscapes and complex terrain, the physics and chemistry of atmospheric trace species at a large scale, the influence of local- and regional-scale emissions and transport on the atmospheric composition, and transient luminous events above thunderstorms. With a large number of instruments and a high hosting capacity, P2OA contributes to atmospheric sciences through (i) building long-term series of atmospheric observations, (ii) hosting experimental field campaigns and instrumental tests, and (iii) educational training in atmospheric observation techniques. In this context, P2OA is part of the French component of the Aerosol, Clouds and Trace Gases Research Infrastructure (ACTRIS-Fr) and also contributes to the Integrated Carbon Observation System (ICOS) research infrastructure and to several European or international networks. Here, we present the complete instrumentation of P2OA and the associated datasets, give a meteorological characterization of the platform, and illustrate the potential of P2OA and its dataset with past or ongoing studies and projects.
Journal Article
Structural sizing of a hydrogen tank for a commercial aircraft
To respond to the current climate crisis, hydrogen-powered aircraft are seen as a promising solution in the aviation sector to cut down
CO
2
emissions. Hydrogen-fueled aircraft present however huge challenges, especially due to the complex storage of hydrogen. To achieve a reasonable fuel energy density for medium- to long-range missions, hydrogen must indeed be stored in liquid form in big and heavy pressurized tanks. Tank design must so be included in conceptual design, which now has an important impact on the aircraft. This study proposes a structural sizing methodology for a liquid hydrogen tank for a commercial aircraft. A parametric model of a cylindrical cryogenic tank placed at the back of the cabin in a conventional aircraft is created and sized to withstand pressure, bending, torsion and shear loads. The process integrates sizing standards for pressurized structures of the current CS-25 regulation in its methodology and remains general enough to consider both integral and non-integral tanks of any dimensions or materials. Initial analyses show a clear dependency of the tank’s performance as well as the optimal stiffening structure configuration on the design pressure.
Journal Article
Growth of a Single MnCr2O4 Spinel on Ni–25Cr–1.5Mn Alloy by the Rhines Pack Method and Photoelectrochemical and Raman Signatures of MnCr2O4 Spinel
A single thin MnCr
2
O
4
spinel layer was synthesized on a Ni–25Cr–1.5Mn alloy by a fine control of oxygen partial pressure using the Rhines-pack method, a technique that utilized an appropriate buffering powder mixture. The spinel was characterized using X-Ray diffraction, Raman spectroscopy and photoelectrochemistry. The cubic spinel MnCr
2
O
4
was formed under the oxygen partial pressure close to 5 × 10
–21
atm at 1050 °C controlled by the buffering Ni–25Cr/Cr
2
O
3
powder mixture. Raman MnCr
2
O
4
spectrum is characterized by five vibrational modes, whereas photoelectrochemical characterization revealed the MnCr
2
O
4
band gap measurement at 3.7 eV with an n-type conductivity.
Journal Article
Genetics of residual feed intake in growing pigs: Relationships with production traits, and nitrogen and phosphorus excretion traits
Residual feed intake (RFI) is defined as the difference between the observed ADFI and the ADFI predicted from production and maintenance requirements. The objectives of this study were to evaluate RFI as a selection criterion to improve feed efficiency and its potential to reduce N and P excretion in 4 pig breeds. Data were collected between 2000 and 2009 in French central test stations for 2 dam breeds [French Landrace (LR) and Large White (LWD)], and 2 sire breeds [Large White (LWS) and Piétrain (PP)]. Numbers of recorded pigs were 6407, 10,694, 2342, and 2448 for the LR, LWD, LWS, and PP breeds, respectively. All PP animals were genotyped for the halothane mutation. This data set was used to calculate RFI equations for each of the 4 breeds, and to estimate genetic parameters for RFI together with growth, carcass, and meat quality traits, and N and P excretion during the test period (35 to 110 kg BW). The RFI explained 20.1% in PP, 26.5% in LWS, 27.6% in LWD, and 29.5% in LR of the phenotypic variability of ADFI. The PP breed differed from the others in this respect, probably due to a lower impact of the variation of body composition on ADFI. Heritability estimates of RFI ranged from 0.21 ± 0.03 (LWD) to 0.33 ± 0.06 (PP) depending on the breed. Heritabilities of N and P excretion traits ranged from 0.29 ± 0.06 to 0.40 ± 0.06. The RFI showed positive genetic correlations with feed conversion ratio (FCR) and excretion traits, these correlations being greater in the sire breeds (from 0.57 to 0.86) than in the dam breeds (from 0.38 to 0.53). Compared with FCR, RFI had weaker genetic correlations with carcass composition, growth rate, and excretion traits. Estimates of genetic correlations between FCR and excretion traits were very close to 1 for all breeds. Finally, excretion traits were, at the genetic level, correlated positively with ADFI, negatively with growth rate and carcass leanness, whereas the halothane n mutation in PP was shown to reduce N and P excretion levels. To conclude, new selection indexes including RFI can be envisaged to efficiently disentangle the responses to selection on growth rate and body composition from those on feed efficiency, with favorable impacts on N and P excretions, particularly in sire pig breeds. However, the switch from FCR to RFI in selection indexes should not resolve the genetic antagonism between feed efficiency and meat quality.
Journal Article
Lomustine is beneficial to older AML with ELN2017 adverse risk profile and intermediate karyotype: a FILO study
We previously reported the benefit of lomustine addition to conventional chemotherapy in older acute myeloid leukemias with nonadverse chromosomal aberrations in the LAM-SA 2007 randomized clinical trial (NCT00590837). A molecular analysis of 52 genes performed in 330 patients included in this trial, 163 patients being treated with lomustine in combination with idarubicin and cytarabine and 167 without lomustine, identified 1088 mutations with an average of 3.3 mutations per patient.
NPM1
,
FLT3
, and
DNMT3A
were the most frequently mutated genes. A putative therapeutic target was identified in 178 patients (54%). Among five molecular classifications analyzed, the ELN2017 risk classification has the stronger association with the clinical evolution. Patients not treated with lomustine have an expected survival prognosis in agreement with this classification regarding the overall and event-free survivals. In strong contrast, lomustine erased the ELN2017 classification prognosis. The benefit of lomustine in nonadverse chromosomal aberrations was restricted to patients with
RUNX1, ASXL1
,
TP53
, and
FLT3
-ITD
high
/
NPM1
WT
mutations in contrast to the intermediate and favorable ELN2017 patients. This post-hoc analysis identified a subgroup of fit elderly AML patients with intermediate cytogenetics and molecular markers who may benefit from lomustine addition to intensive chemotherapy.
Journal Article
OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions
Heterogeneity of interindividual and intraindividual responses to interventions is often observed in randomized, controlled trials for obesity. To address the global epidemic of obesity and move toward more personalized treatment regimens, the global research community must come together to identify factors that may drive these heterogeneous responses to interventions. This project, called OBEDIS (OBEsity Diverse Interventions Sharing – focusing on dietary and other interventions), provides a set of European guidelines for a minimal set of variables to include in future clinical trials on obesity, regardless of the specific endpoints. Broad adoption of these guidelines will enable researchers to harmonize and merge data from multiple intervention studies, allowing stratification of patients according to precise phenotyping criteria which are measured using standardized methods. In this way, studies across Europe may be pooled for better prediction of individuals’ responses to an intervention for obesity – ultimately leading to better patient care and improved obesity outcomes.
Journal Article
ReefTEMPS: the Pacific Islands coastal temperature network
While the rise in global ocean temperature continues its course, reaching 1.45±0.12 °C above pre-industrial level according to the World Meteorological Organization in 2023, marine heatwave frequencies and intensities increase. Consequently, coral reef ecosystems, which are among the most vulnerable environments, are strongly impacted by dystrophic events and corals experiencing increasing frequencies of bleaching events. That has devastating consequences for the Pacific Island countries and territories (PICTs) that strongly rely on these ecosystems. In situ observation remains the best alternative for providing accurate characterization of long-term trends and extremes in these shallow environments. This paper presents the coastal temperature dataset of the ReefTEMPS monitoring network (Varillon et al., 2025, https://doi.org/10.17882/55128; Liao et al., 2025, https://doi.org/10.17882/82291) in which moored stations are implemented over a number of PICTs over a wide region in the western and central South Pacific from New Caledonia to French Polynesia. These in situ temperature time series are unique in several ways: in the length of some historical stations dating back to 1958 for the oldest, thus providing more than 65 years of daily data; in the number of countries sampled (16 PICTs); and in the variety of coral ecosystems monitored (from atolls to high islands and from barrier reefs' external slopes to shallow and narrow lagoons). Measurement devices have evolved over the years to provide increasingly precise and frequent observations, so the ReefTEMPS network was endorsed as a French National Observation Service in 2020, a label ensuring quality-controlled and open-access data of long-term observations. All stations are publicly available in ASCII or formatted NetCDF files either in the ReefTEMPS dedicated information system, which also allows for a quick visualization of time series, or on the SEANOE marine data platform. All links and accesses to these temperature time series are provided herein. The longevity of these temperature time series allows for diagnosing long-term trends, highlighting the influence of multiple processes on temperature dynamics (e.g. internal waves, cyclones, seasonal, and climate modes) and documenting the time evolution of extreme events. All files are made publicly available on dedicated SEANOE repositories.
Journal Article
Prognosis of Atrial Fibrillation with or without Comorbidities: Analysis of Younger Adults from a Nationwide Database
Objective: To assess the prognosis of AF patients with or without cardiac or extra-cardiac concomitant conditions. Participants and Methods: All consecutive patients diagnosed with AF admitted to French hospitals between 2011 and 2020 were identified. Patients were classified into four groups: (1) > 60 yo; (2) with known cardiac disease (KCD group); (3) with extra-cardiac comorbidities (ECC); and 4) AF without KCD or ECC (“Lone AF”). Results: Altogether 2,435,541 patients were identified, from which 2,203,702 patients aged >60 years and 231,839 patients aged <60 years (with KCD (55.2%), with ECC (14.7%) and with “Lone AF” (30.1%)). During follow-up, the incidences of all-cause and CV deaths were 13.7%, 5.7%, 6.2%, and 2.3%, and 4.2%, 1.7%, 0.8%, and 0.3% in the older than 60 yo group, KCD group, ECC group and “Lone AF” AF group, respectively. In the age and sex-adjusted analysis (patients < 60 yo), patients with AF and KCD had worse outcomes than patients with “Lone AF” for all major cardiac events. Conclusion: There are three distinct prognostic criteria based on the presence or lack of HD or extra-cardiac concomitant comorbidities. Patients in the so-called “Lone AF” group remain severe in terms of CV events but still with a lower incidence than the patients with associated KCD or ECC. The presence of KCD or ECC makes it possible to distinguish a profile in terms of events that are very different between the patients.
Journal Article