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\"Thom and Jennifer Harlow are the perfect couple, with three perfect children. They maybe two of the biggest mega movie stars in the world, but they're also great parents, philanthropists and just all-around good people. When they disappear without a word from their ranch, facts are hard to find. They live behind such a high wall of security and image control that even world-renowned Private Investigator Jack Morgan can't get to the truth. But as Jack keeps probing, secrets sprout thick and fast--and the world's golden couple may emerge as hiding behind a world of desperation and deception that the wildest reality show couldn't begin to unveil. Murder is only the opening scene\"-- Provided by publisher.

Borrowing treatment principles from acute and end-of-life pain care, particularly a focus on pain intensity, has had harmful consequences for patients with chronic pain. Multimodal therapy, by contrast, aims to reduce pain-related distress, disability, and suffering. Pain causes widespread suffering, disability, social displacement, and expense. Whether the issue is viewed from a moral, political, or public health perspective, pain that can be relieved should be relieved. Yet the most rapidly effective drugs for relieving pain — opioids — are caught up in a morass of concerns about addiction. Achieving a balance between the benefits and potential harms of opioids has become a matter of national importance. The United States recently established a national plan to address pain, as Canada, Australia, Portugal, and Malaysia have previously done. 1 This National Pain Strategy grew out of recognition by the . . .

Using a solid-phase molecular imprinting technique, high-affinity nanoparticles (nanoMIPs) selective for the target antibiotics, ciprofloxacin, moxifloxacin, and ofloxacin have been synthesised. These have been applied in the development of a surface plasmon resonance (SPR) sensor for the detection of the three antibiotics in both river water and milk. The particles produced demonstrated good uniformity with approximate sizes of 65.8 ± 1.8 nm, 76.3 ± 4.1 nm, and 85.7 ± 2.5 nm, and were demonstrated to have affinities of 36.2 nM, 54.7 nM, and 34.6 nM for the ciprofloxacin, moxifloxacin, and ofloxacin nanoMIPs, respectively. Cross-reactivity studies highlighted good selectivity towards the target antibiotic compared with a non-target antibiotic. Using spiked milk and river water samples, the nanoMIP-based SPR sensor offered comparable affinity with 66.8 nM, 33.4 nM, and 55.0 nM (milk) and 39.3 nM, 26.1 nM, and 42.7 nM (river water) for ciprofloxacin, moxifloxacin, and ofloxacin nanoMIPs, respectively, to that seen within a buffer standard. Estimated LODs for the three antibiotic targets in both milk and river water were low nM or below. The developed SPR sensor showed good potential for using the technology for the capture and detection of antibiotics from food and environmental samples.

The Berlin office of the world's most renowned investigation firm looks into the disappearance of an agent, Chris Schneider, whose last case involved an unfaithful billionaire, a cheating soccer player and a seedy nightclub owner.

Mycobacterium abscessus is a pulmonary pathogen that exhibits intrinsic resistance to antibiotics, but the factors driving this resistance are incompletely understood. Insufficient intracellular drug accumulation could explain broad-spectrum resistance, but whether antibiotics fail to accumulate in M. abscessus and the mechanisms required for drug exclusion remain poorly understood. We measured antibiotic accumulation in M. abscessus using mass spectrometry and found a wide range of drug accumulation across clinically relevant antibiotics. Of these compounds, linezolid accumulates the least, suggesting that inadequate uptake impacts its efficacy. We utilized transposon mutagenesis screening to identify genes that cause linezolid resistance and found multiple transporters that promote membrane permeability or efflux, including an uncharacterized protein that effluxes linezolid and several chemically related antibiotics. This demonstrates that membrane permeability and drug efflux are critical mechanisms of antibiotic resistance in M. abscessus and suggests that targeting membrane transporters could potentiate the efficacy of certain antibiotics.

Cancer cell metabolism is heavily influenced by microenvironmental factors, including nutrient availability. Therefore, knowledge of microenvironmental nutrient levels is essential to understand tumor metabolism. To measure the extracellular nutrient levels available to tumors, we utilized quantitative metabolomics methods to measure the absolute concentrations of >118 metabolites in plasma and tumor interstitial fluid, the extracellular fluid that perfuses tumors. Comparison of nutrient levels in tumor interstitial fluid and plasma revealed that the nutrients available to tumors differ from those present in circulation. Further, by comparing interstitial fluid nutrient levels between autochthonous and transplant models of murine pancreatic and lung adenocarcinoma, we found that tumor type, anatomical location and animal diet affect local nutrient availability. These data provide a comprehensive characterization of the nutrients present in the tumor microenvironment of widely used models of lung and pancreatic cancer and identify factors that influence metabolite levels in tumors. In the body, cancer cells can rely on different nutrients than normal cells, and they can use these nutrients in a different way. What cancer cells consume also depends on what is available in their immediate environment. In a tumor, cells grab nutrients from the ‘interstitial’ fluid that surrounds them, but what is present in this liquid may vary within tumors arising in different locations. Understanding what nutrients are ‘on the menu’ in specific tumors would help to target diseased cells while sparing healthy ones, but this knowledge has been difficult to obtain. To investigate this, Sullivan et al. used a technique called mass spectrometry to measure the amounts of 120 nutrients present in the interstitial fluid of mouse pancreas and lung tumors. Different levels of nutrients were found in the two types of tumors, and analyses showed that what was present in the interstitial fluid depended on the type of cancer cells, where the tumor was located, and what the animals ate. This suggests that cancer cells may have different needs because they are limited in what they have access to. It remains to be seen whether the nutrients levels found in mouse tumors are the same as those in humans. Armed with this knowledge, it may then be possible to feed cancer cells grown in the laboratory with the nutrient menu that they would have access to in the body. This could help identify new cancer treatments.

\"Inspired by a true story, two teens kidnapped by an African warlord find salvation through love in a powerful and healing historical novel. Anthony Opoka and Florence Okori are coming of age in Uganda in the 1990s. Outstanding students, they believe in being good humans before they are kidnapped and forced into the fanatical Lord's Resistance Army. In a legion of young recruits, no one gets closer than Anthony to powerful messianic warlord Joseph Kony and his darkest secrets. To stay sane as he spirals through chaos, Anthony clings to his childhood lessons about being a good human. Florence's upbringing grounds her, too, helping her keep her dreams alive even as she's pulled deeper into the insanity of Kony's war. At the lowest points of their lives, certain they'll never go home, Anthony and Florence meet by chance, fall in love, and begin to dream of surviving their captivity. They devote their lives to helping their fellow child soldiers escape bondage and return to their families and redemption by following the stars. By turns tender, shocking, moving, desperate, and ultimately triumphant, Florence and Anthony's story is an epic drama of humanity, a life-affirming tale, and an experience readers will never forget.\" -- Goodreads.

The explosive death of a star as a supernova is one of the most dramatic events in the Universe. Supernovae have an outsized impact on many areas of astrophysics: they are major contributors to the chemical enrichment of the cosmos and significantly influence the formation of subsequent generations of stars and the evolution of galaxies. Here we review the observational properties of thermonuclear supernovae—exploding white dwarf stars resulting from the stellar evolution of low-mass stars in close binary systems. The best known objects in this class are type-Ia supernovae (SNe Ia), astrophysically important in their application as standardizable candles to measure cosmological distances and the primary source of iron group elements in the Universe. Surprisingly, given their prominent role, SN Ia progenitor systems and explosion mechanisms are not fully understood; the observations we describe here provide constraints on models, not always in consistent ways. Recent advances in supernova discovery and follow-up have shown that the class of thermonuclear supernovae includes more than just SNe Ia, and we characterize that diversity in this review.Thermonuclear supernovae — those involving the explosion of a white dwarf — and particularly type-Ia supernovae, have become indispensable tools for observationally measuring the expansion of the Universe. However, we still do not fully understand these objects, especially the range of progenitor systems that give rise to them. Future observations will enable us to make headway.