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ChatGPT, an AI-based chatbot with automatic code generation abilities, has shown its promise in improving the quality of programming education by providing learners with opportunities to better understand the principles of programming. However, limited empirical studies have explored the impact of ChatGPT on learners’ programming processes. This study employed a quasi-experimental design to explore the possible impact of ChatGPT-facilitated programming mode on college students’ programming behaviors, performances, and perceptions. 82 college students were randomly divided into two classes. One class employed ChatGPT-facilitated programming (CFP) practice and the other class utilized self-directed programming (SDP) mode. Mixed methods were utilized to collect multidimensional data. Data analysis uncovered some intriguing results. Firstly, students in the CFP mode had more frequent behaviors of debugging and receiving error messages, as well as pasting console messages on the website and reading feedback. At the same time, students in the CFP mode had more frequent behaviors of copying and pasting codes from ChatGPT and debugging, as well as pasting codes to ChatGPT and reading feedback from ChatGPT. Secondly, CFP practice would improve college students’ programming performance, while the results indicated that there was no statistically significant difference between the students in CFP mode and the SDP mode. Thirdly, student interviews revealed three highly concerned themes from students' user experience about ChatGPT: the services offered by ChatGPT, the stages of ChatGPT usage, and experience with ChatGPT. Finally, college students’ perceptions toward ChatGPT significantly changed after CFP practice, including its perceived usefulness, perceived ease of use, and intention to use. Based on these findings, the study proposes implications for future instructional design and the development of AI-powered tools like ChatGPT.

Reversible post-translational modifications represent a mechanism to control tumor metabolism. Here we show that mitochondrial Sirtuin5 (SIRT5), which mediates lysine desuccinylation, deglutarylation, and demalonylation, plays a role in colorectal cancer (CRC) glutamine metabolic rewiring. Metabolic profiling identifies that deletion of SIRT5 causes a marked decrease in 13 C-glutamine incorporation into tricarboxylic-acid (TCA) cycle intermediates and glutamine-derived non-essential amino acids. This reduces the building blocks required for rapid growth. Mechanistically, the direct interaction between SIRT5 and glutamate dehydrogenase 1 (GLUD1) causes deglutarylation and functional activation of GLUD1, a critical regulator of cellular glutaminolysis. Consistently, GLUD1 knockdown diminishes SIRT5-induced proliferation, both in vivo and in vitro. Clinically, overexpression of SIRT5 is significantly correlated with poor prognosis in CRC. Thus, SIRT5 supports the anaplerotic entry of glutamine into the TCA cycle in malignant phenotypes of CRC via activating GLUD1. Tumour metabolism can be controlled through post-translational modifications. Here the authors show that Sirtuin5 promotes glutaminolysis in colorectal cancer cells via glutamate dehydrogenase-1, a critical regulator of glutaminolysis, inducing its deglutarylation and functional activation.

Rechargeable aqueous zinc-ion batteries are a promising candidate for next-generation energy storage devices. However, their practical application is limited by the severe safety issue caused by uncontrollable dendrite growth on zinc anodes. Here we develop faceted titanium dioxide with relatively low zinc affinity, which can restrict dendrite formation and homogenize zinc deposition when served as the protective layer on zinc anodes. The as-prepared zinc anodes can be stripped and plated steadily for more than 460 h with low voltage hysteresis and flat voltage plateau in symmetric cells. This work reveals the key role of crystal orientation in zinc affinity and its internal mechanism is suitable for various crystal materials applied in the surface modification of other metal anodes such as lithium and sodium. Zinc affinity plays a key role in the zinc plating and stripping processes but its internal mechanism is still unclear. Here, the authors report a protective layer with controllable zinc affinity by adjusting the crystal orientation to suppress the dendrite growth on the zinc anode interface.

Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of fat in more than 5% of hepatocytes in the absence of excessive alcohol consumption and other secondary causes of hepatic steatosis. In 2020, the more inclusive term metabolic (dysfunction)-associated fatty liver disease (MAFLD) — defined by broader diagnostic criteria — was proposed to replace the term NAFLD. The new terminology and revised definition better emphasize the pathogenic role of metabolic dysfunction and uses a set of definitive, inclusive criteria for diagnosis. Diagnosis of MAFLD is based on evidence of hepatic steatosis (as assessed by liver biopsy, imaging techniques or blood biomarkers and scores) in persons who are overweight or obese and have type 2 diabetes mellitus or metabolic dysregulation, regardless of the coexistence of other liver diseases or excessive alcohol consumption. The known association between NAFLD and chronic kidney disease (CKD) and our understanding that CKD can occur as a consequence of metabolic dysfunction suggests that individuals with MAFLD — who by definition have fatty liver and metabolic comorbidities — are at increased risk of CKD. In this Perspective article, we discuss the clinical associations between MAFLD and CKD, the pathophysiological mechanisms by which MAFLD may increase the risk of CKD and the potential drug treatments that may benefit both conditions.‘Metabolic dysfunction-associated fatty liver disease’ has been proposed as a replacement term for ‘Non-alcoholic fatty liver disease’, in part to recognize the fact that this liver disease occurs within a series of complex metabolic disorders. This Perspective article discusses the clinical associations and pathophysiological mechanisms underpinning the relationship between metabolic dysfunction-associated fatty liver disease and chronic kidney disease.

Although the closed pore structure plays a key role in contributing low-voltage plateau capacity of hard carbon anode for sodium-ion batteries, the formation mechanism of closed pores is still under debate. Here, we employ waste wood-derived hard carbon as a template to systematically establish the formation mechanisms of closed pores and their effect on sodium storage performance. We find that the high crystallinity cellulose in nature wood decomposes to long-range carbon layers as the wall of closed pore, and the amorphous component can hinder the graphitization of carbon layer and induce the crispation of long-range carbon layers. The optimized sample demonstrates a high reversible capacity of 430 mAh g −1 at 20 mA g −1 (plateau capacity of 293 mAh g −1 for the second cycle), as well as good rate and stable cycling performances (85.4% after 400 cycles at 500 mA g −1 ). Deep insights into the closed pore formation will greatly forward the rational design of hard carbon anode with high capacity. It is essential to investigate the formation mechanism of closed pore, which contributes to low-voltage plateau capacity of hard carbon anode in sodium ion batteries. Herein, the authors explore the impact of wood precursor components and carbonization temperature on closed pore formation in hard carbon for enhanced battery performance.

The venoarteriolar and myogenic response (VMR) is a non‐adrenergic, non‐baroreflex‐mediated mechanism that increases local vascular resistance and contributes to blood pressure (BP) regulation during orthostasis. Despite the importance of the VMR in human cardiovascular control, no information exists elucidating possible differences in the VMR with ageing and sex. We studied 26 healthy young adults [9 male; mean (SD) 28 (4) years old] and 18 healthy older adults [7 male; 71 (3) years old] during acute arm and leg dependency (i.e., limb lowering below heart level) to evoke the VMR. Brachial and femoral artery blood flows were assessed with duplex ultrasound. The VMR was estimated as the percentage reduction in vascular conductance (blood flow/mean arterial BP; in millilitres per minute per millimetre of mercury) from baseline during 5 min of limb dependency. Arm VMR was attenuated in the older versus young adults [−8.7 (1.9)% vs. −26.6 (2.4)%, p  < 0.001]. Likewise, leg VMR was also attenuated in the older versus young adults [−14.4 (0.8)% vs. −29.1 (2.2)%, p  < 0.001]. Despite these age‐related differences, there were no sex differences for leg ( p  = 0.096) or arm VMR ( p  = 0.825). These data suggest that ageing attenuates the VMR in both the upper and lower limbs, but sex does not impact these responses. This phenomenon might contribute to altered BP regulation in older adults, either protecting against excessive orthostatic BP elevations or contributing to orthostatic hypotension. Future research is needed to determine the mechanisms of an attenuated VMR with ageing and whether these findings extend to populations with hypertension and cardiovascular/metabolic disease. What is the central question of this study? The venoarteriolar and myogenic response (VMR) contributes to blood flow and pressure regulation, particularly during orthostasis. Despite its importance in cardiovascular control, the impacts of ageing and sex on the VMR remain unclear. What is the main finding and its importance? Healthy older adults, relative to young adults, exhibit an attenuated VMR in both the arm and the leg during acute limb lowering, with no sex‐specific differences in either age group. This reduced VMR might either protect against excessive rises in blood pressure during orthostasis or contribute to orthostatic hypotension in older adults.

Smart cities improve services for businesses, among many other benefits. A comprehensive understanding and effective utilization of these advantages is crucial for promoting business development. Using panel data from Chinese listed companies (2010–2020), this study employs a multi-stage DiD model to investigate the impact of smart cities on corporate earnings management. The findings indicate that the smart city pilot policy has significantly reduced corporate earnings management. Further analysis suggests that smart cities primarily reduce earnings management by improving firms’ external information environments. Additionally, the results show that the policy impact of smart cities is more significant in regions with lower regulatory intensity or higher marketization levels, compared to regions with higher regulatory intensity or lower marketization levels. Similarly, firms in less concentrated markets or those more closely related to smart city development tend to experience greater reductions in earnings management due to smart city construction, unlike firms in more concentrated markets or those less involved. Finally, this paper offers several brief suggestions.

Background Pulmonary fibrosis (PF) is a devastating disease characterized by remodeling of lung architecture and abnormal deposition of fibroblasts in parenchymal tissue and ultimately results in respiratory failure and death. Preclinical studies suggest that mesenchymal stem cell (MSC) administration may be a safe and promising option in treating PF. The objective of our meta-analysis is to assess the efficacy of MSC therapy in preclinical models of PF. Methods We performed a comprehensive literature search in PubMed, EMBASE, Web of Science, and Cochrane Library databases from inception to March 17, 2021. Studies that assessed the efficacy of MSC therapy to animals with PF were included. The SYRCLE bias risk tool was employed to evaluate the bias of included studies. The primary outcomes included survival rate and pulmonary fibrosis scores. Meta-analysis was conducted via Cochrane Collaboration Review Manager (version 5.4) and Stata 14.0 statistical software. Results A total of 1120 articles were reviewed, of which 24 articles met inclusion criteria. Of these, 12 studies evaluated the survival rate and 20 studies evaluated pulmonary fibrosis scores. Compared to the control group, MSC therapy was associated with an improvement in survival rate (odds ratios (OR) 3.10, 95% confidence interval (CI) 2.06 to 4.67, P < 0.001, I 2 = 0%) and a significant reduction in pulmonary fibrosis scores (weighted mean difference (WMD) 2.05, 95% CI −2.58 to −1.51, P < 0.001, I 2 = 90%). Conclusions MSC therapy is a safe and effective method that can significantly improve the survival and pulmonary fibrosis of PF animals. These results provide an important basis for future translational clinical studies.

News dissemination plays a vital role in supporting people to incorporate beneficial actions during public health emergencies, thereby significantly reducing the adverse influences of events. Based on big data from YouTube, this research study takes the declaration of COVID-19 National Public Health Emergency (PHE) as the event impact and employs a DiD model to investigate the effect of PHE on the news dissemination strength of relevant videos. The study findings indicate that the views, comments, and likes on relevant videos significantly increased during the COVID-19 public health emergency. Moreover, the public’s response to PHE has been rapid, with the highest growth in comments and views on videos observed within the first week of the public health emergency, followed by a gradual decline and returning to normal levels within four weeks. In addition, during the COVID-19 public health emergency, in the context of different types of media, lifestyle bloggers, local media, and institutional media demonstrated higher growth in the news dissemination strength of relevant videos as compared to news & political bloggers, foreign media, and personal media, respectively. Further, the audience attracted by related news tends to display a certain level of stickiness, therefore this audience may subscribe to these channels during public health emergencies, which confirms the incentive mechanisms of social media platforms to foster relevant news dissemination during public health emergencies. The proposed findings provide essential insights into effective news dissemination in potential future public health events.

Aqueous zinc‐ion batteries (ZIBs) have been intensively investigated as potential energy storage devices on account of their low cost, environmental benignity, and intrinsically safe merits. With the exploitation of high‐performance cathode materials, electrolyte systems, and in‐depth mechanism investigation, the electrochemical performances of ZIBs have been greatly enhanced. However, there are still some challenges that need to be overcome before its commercialization. Among them, the obstinate dendrites, corrosion, and hydrogen evolution reaction (HER) on Zn anodes are critical issues that severely limit the practical applications of ZIBs. To address these issues, various strategies have been proposed, and tremendous progress has been achieved in the past few years. In this article, we analyze the origins and effects of the dendrites, corrosion, and HER on Zn anodes in neutral and mildly acid aqueous solutions at first. And then, a scientific understanding of the fundamental design principles and strategies to suppress these problems are emphasized. Apart from these, this article also puts forward some requirements for the practical applications of Zn anodes as well as several cost‐effective‐modifying strategies. Finally, perspectives on the future development of Zn anodes in aqueous solutions are also briefly anticipated. This article provides pertinent insights into the challenges on anodes for the development of high‐performance ZIBs, which will greatly contribute to their practical applications. This article summarizes the causes and effects of Zn dendrites, corrosion, and hydrogen evolution reaction (HER) in aqueous zinc‐ion batteries (ZIBs). Moreover, recent advances in tackling these three issues toward zinc anode are systematically analyzed. Finally, several perspectives for the overall performance of zinc anodes have been put forward.