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"Wang, Ying"
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Towards environmental performance through responsible environmental intentions and behavior: Does environmental law cognition really matter among Chinese farmers
Rapid agricultural expansion, marked by unsustainable practices, has contributed significantly to environmental degradation globally. In response to China’s escalating environmental concerns, recent environmental legislation has sought to disseminate information and promote awareness of environmental preservation among residents. This study aims to investigate the influential role of citizen environmental intentions and activist environmental intentions on responsible behavior for achieving environmental performance (EP). Moreover, the moderating influence of these environmental laws on the relationship between environment-protecting intentions and behavior, with a focus on legal cognition. Utilizing a population of 3150 farmers we select 603 farmers using simple random sampling and, this study applies the theory of planned behavior within a structural equation model framework. The findings affirm that farmers’ perceived behavior control, personal factors, and attitudes directly impact both citizen and activist intentions, subsequently influencing both types of environmental-oriented behavior. Notably, the study identifies a stronger inward attitude effect compared to the outward attitude in both types of farmers’ intentions. Additionally, legal cognition among farmers emerges as a crucial moderator, influencing the link between environmental intentions and behavior. The results suggest that as farmers become more familiar with environmental laws, the direct effect of their intentions on environmentally oriented behavior intensifies. Hence, the legal obligations play an essential role in shaping the farmers’ pro-environmental behavior. This study aligns the individual level environmental intentions with farmer’s law cognition for offering interesting insights to develop and implement imminent environmental policies. Hence, this study benefits to both practitioners and policy makers’ contextualizing Chinese agricultural sector.
Journal Article
LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer
Background
Long noncoding RNAs (lncRNAs) play nonnegligible roles in the epigenetic regulation of cancer cells. This study aimed to identify a specific lncRNA that promotes the colorectal cancer (CRC) progression and could be a potential therapeutic target.
Methods
We screened highly expressed lncRNAs in human CRC samples compared with their matched adjacent normal tissues. The proteins that interact with
LINRIS
(Long Intergenic Noncoding RNA for IGF2BP2 Stability) were confirmed by RNA pull-down and RNA immunoprecipitation (RIP) assays. The proliferation and metabolic alteration of CRC cells with
LINRIS
inhibited were tested in vitro and in vivo
.
Results
LINRIS
was upregulated in CRC tissues from patients with poor overall survival (OS), and
LINRIS
inhibition led to the impaired CRC cell line growth. Moreover, knockdown of
LINRIS
resulted in a decreased level of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), a newly found N
6
-methyladenosine (m
6
A) ‘reader’.
LINRIS
blocked K139 ubiquitination of IGF2BP2, maintaining its stability. This process prevented the degradation of IGF2BP2 through the autophagy-lysosome pathway (ALP). Therefore, knockdown of
LINRIS
attenuated the downstream effects of IGF2BP2, especially MYC-mediated glycolysis in CRC cells. In addition, the transcription of
LINRIS
could be inhibited by GATA3 in CRC cells. In vivo experiments showed that the inhibition of
LINRIS
suppressed the proliferation of tumors in orthotopic models and in patient-derived xenograft (PDX) models.
Conclusion
LINRIS
is an independent prognostic biomarker for CRC. The
LINRIS
-IGF2BP2-MYC axis promotes the progression of CRC and is a promising therapeutic target.
Journal Article
Matching visibility and performance : a standing challenge for world-class universities
World-class universities (WCU) are regarded as cornerstone institutions of any academic system and imperative to develop a nation?s competitiveness in the global knowledge economy. Visibility and performance are among the most watched concepts in relation to develop WCUs, but remain complicated in nature and with no agreed upon definitions. Existing literature have focused on how to raise universities? prestige, status, impact and rankings in the global and regional arena on the one hand, and how to enhance universities? quality, efficiency, effectiveness and academic output on the other. However, whether visibility is a legitimate indicator of performance, or vice versa, is yet to be answered. This book provides insights of developing academic excellence from global, national and institutional perspectives, and intends to stimulate discussion on how universities can be?globally visible and locally engaged? and how visibility and performance can be integrated and balanced in practice.
Book
Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province
The 2019 novel coronavirus (2019-nCoV) causing an outbreak of pneumonia in Wuhan, Hubei province of China was isolated in January 2020. This study aims to investigate its epidemiologic history, and analyze the clinical characteristics, treatment regimens, and prognosis of patients infected with 2019-nCoV during this outbreak.
Clinical data from 137 2019-nCoV-infected patients admitted to the respiratory departments of nine tertiary hospitals in Hubei province from December 30, 2019 to January 24, 2020 were retrospectively collected, including general status, clinical manifestations, laboratory test results, imaging characteristics, and treatment regimens.
None of the 137 patients (61 males, 76 females, aged 20-83 years, median age 57 years) had a definite history of exposure to Huanan Seafood Wholesale Market. Major initial symptoms included fever (112/137, 81.8%), coughing (66/137, 48.2%), and muscle pain or fatigue (44/137, 32.1%), with other, less typical initial symptoms observed at low frequency, including heart palpitations, diarrhea, and headache. Nearly 80% of the patients had normal or decreased white blood cell counts, and 72.3% (99/137) had lymphocytopenia. Lung involvement was present in all cases, with most chest computed tomography scans showing lesions in multiple lung lobes, some of which were dense; ground-glass opacity co-existed with consolidation shadows or cord-like shadows. Given the lack of effective drugs, treatment focused on symptomatic and respiratory support. Immunoglobulin G was delivered to some critically ill patients according to their conditions. Systemic corticosteroid treatment did not show significant benefits. Notably, early respiratory support facilitated disease recovery and improved prognosis. The risk of death was primarily associated with age, underlying chronic diseases, and median interval from the appearance of initial symptoms to dyspnea.
The majority of patients with 2019-nCoV pneumonia present with fever as the first symptom, and most of them still showed typical manifestations of viral pneumonia on chest imaging. Middle-aged and elderly patients with underlying comorbidities are susceptible to respiratory failure and may have a poorer prognosis.
Journal Article
How world-class universities affect global higher education : influences and responses
World-class universities, commonly recognized as global research universities or flagship universities, are cornerstone institutions embedded in any academic system and play an important role in developing a nation?s competitiveness in the global knowledge economy. The development of world-class universities is high on the policy agenda of various stakeholders across the globe. In the past few years, an increasing number of nations, regions and higher education institutions in both developed and developing countries have joined the same race for academic excellence and have adopted a range of development strategies and implemented various reforms. From a comparative perspective, How World-Class Universities Affect Global Higher Education intends to provide an in-depth picture of excellence initiatives and relevant policies adopted in various nations and regions, and to reflect opportunities and challenges of developing excellence.
Book
In-situ cross-linking strategy for efficient and operationally stable methylammoniun lead iodide solar cells
Long-term operational stability is the foremost issue delaying the commercialization of perovskite solar cells (PSCs). Here we demonstrate an in-situ cross-linking strategy for operationally stable inverted MAPbI
3
PSCs through the incorporation of a cross-linkable organic small molecule additive trimethylolpropane triacrylate (TMTA) into perovskite films. TMTA can chemically anchor to grain boundaries and then in-situ cross-link to a robust continuous network polymer after thermal treatment, thus enhancing the thermal, water-resisting and light-resisting properties of organic/perovskite films. As a result, the cross-linked PSCs exhibit 590-fold improvement in operational stability, retaining nearly 80% of their initial efficiency after continuous power output for 400 h at maximum power point under full-sun AM 1.5 G illumination of Xenon lamp without any UV-filter. In addition, under moisture or thermal (85 °C) conditions, cross-linked TMTA-based PSCs also show excellent stability with over 90% of their initial or post burn-in efficiency after aging for over 1000 h.
The stability of perovskite solar cell remains the biggest challenge that hinders its commercialization. Here Li et al. incorporate crosslinkable molecules to form a crosslinked perovskite film and increase the device operational stability by 590 times to 400 h under standard Xenon lamp without filters.
Journal Article
Hollow-core conjoined-tube negative-curvature fibre with ultralow loss
Countering the optical network ‘capacity crunch’ calls for a radical development in optical fibres that could simultaneously minimize nonlinearity penalties, chromatic dispersion and maximize signal launch power. Hollow-core fibres (HCF) can break the nonlinear Shannon limit of solid-core fibre and fulfil all above requirements, but its optical performance need to be significantly upgraded before they can be considered for high-capacity telecommunication systems. Here, we report a new HCF with conjoined-tubes in the cladding and a negative-curvature core shape. It exhibits a minimum transmission loss of 2 dB km
−1
at 1512 nm and a <16 dB km
−1
bandwidth spanning across the O, E, S, C, L telecom bands (1302–1637 nm). The debut of this conjoined-tube HCF, with combined merits of ultralow loss, broad bandwidth, low bending loss, high mode quality and simple structure heralds a new opportunity to fully unleash the potential of HCF in telecommunication applications.
Countering the optical network ‘capacity crunch’ requires developments in optical fibres. Here, the authors report a hollow-core fibre with conjoined tubes in the cladding and a negative-curvature core shape. It exhibits a transmission loss of 2 dB/km at 1512 nm and less than 16 dB/km bandwidth in the 1302–1637 nm range.
Journal Article