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Diarrheal diseases caused by intestinal protozoan parasites are a major food-borne public health problem across the world. Vegetables and fruits provide important nutrients and minerals, but are also common sources of some food-borne human pathogenic microorganisms. The contamination of raw vegetables and fruits with human pathogenic parasites are now a global public health threat, despite the health benefits of these foods in non-pharmacological prophylaxes against diseases. A large number of reports have documented the contamination of vegetables or fruits with human pathogenic microorganisms. In this paper, we reviewed the contamination and detection methods of human pathogenic intestinal protozoans that are frequently recovered from raw vegetables and fruits. The protozoan parasites include Cryptosporidium spp., Giardia duodenalis , Cyclospora cayetanensis , Entamoeba spp., Toxoplasma gondii , Balantioides coli , Blastocystis sp., Cystoisospora belli and Enterocytozoon bieneusi . The risk factors involved in the contamination of vegetables and fruits with parasites are also assessed.

Reactive oxygen species (ROS)-induced apoptosis is a promising treatment strategy for malignant neoplasms. However, current systems are highly dependent on oxygen status and/or external stimuli to generate ROS, which greatly limit their therapeutic efficacy particularly in hypoxic tumors. Herein, we develop a biomimetic nanoflower based on self-assembly of nanozymes that can catalyze a cascade of intracellular biochemical reactions to produce ROS in both normoxic and hypoxic conditions without any external stimuli. In our formulation, PtCo nanoparticles are firstly synthesized and used to direct the growth of MnO 2 . By adjusting the ratio of reactants, highly-ordered MnO 2 @PtCo nanoflowers with excellent catalytic efficiency are obtained, where PtCo behaves as oxidase mimic and MnO 2 functions as catalase mimic. In this way, the well-defined MnO 2 @PtCo nanoflowers not only can relieve hypoxic condition but also induce cell apoptosis significantly through ROS-mediated mechanism, thereby resulting in remarkable and specific inhibition of tumor growth. Hypoxic tumors are resistant to dynamic therapy, limiting potential treatment options. Here, the authors describe a nanoflower where oxidase mimicking PtCo nanoparticles are decorated with catalase mimicking MnO 2 to reverse tumor hypoxia and generate reactive oxygen species for dynamic therapy.

The reasonable construction and application of business management data processing system not only improve the efficiency of business management and operation, but also improve the level of business information, it also provides abundant and high-quality data resources for standardizing the practice of enterprise management. Therefore, in the \"Internet +\" mature development environment, we should adhere to the computer information management model as the basis to actively explore the enterprise business management data processing system construction strategy. Based on the analysis of the construction background of business management data processing system, the construction strategy of Business Management Data Processing System under the computer information management model is put forward.

Switching macrophages from a pro-tumor type to an anti-tumor state is a promising strategy for cancer immunotherapy. Existing agents, many derived from bacterial components, have safety or specificity concerns. Here, we postulate that the structures of the bacterial signals can be mimicked by using non-toxic biomolecules of simple design. Based on bioactivity screening, we devise a glucomannan polysaccharide with acetyl modification at a degree of 1.8 (acGM-1.8), which specifically activates toll-like receptor 2 (TLR2) signaling and consequently induces macrophages into an anti-tumor phenotype. For acGM-1.8, the degree of acetyl modification, glucomannan pattern, and acetylation-induced assembly are three crucial factors for its bioactivity. In mice, intratumoral injection of acGM-1.8 suppresses the growth of two tumor models, and this polysaccharide demonstrates higher safety than four classical TLR agonists. In summary, we report the design of a new, safe, and specific TLR2 agonist that can generate macrophages with strong anti-tumor potential in mice. Turning tumour promoting macrophages into an anti-tumour phenotype is an attractive therapeutic strategy. Here, the authors develop a polysaccharide-based structure that mimicks pathogen-associated molecular patterns and, by activating the toll-like receptors on macrophage surface, promotes a safe anti-tumour immune response in mouse models.

Atherosclerosis is a chronic inflammatory disease; unstable atherosclerotic plaque rupture, vascular stenosis, or occlusion caused by platelet aggregation and thrombosis lead to acute cardiovascular disease. Atherosclerosis-related inflammation is mediated by proinflammatory cytokines, inflammatory signaling pathways, bioactive lipids, and adhesion molecules. This review discusses the effects of inflammation and the systemic inflammatory signaling pathway on atherosclerosis, the role of related signaling pathways in inflammation, the formation of atherosclerosis plaques, and the prospects of treating atherosclerosis by inhibiting inflammation.

Although Prussian blue nanozymes (PBNZ) are widely applied in various fields, their catalytic mechanisms remain elusive. Here, we investigate the long-term catalytic performance of PBNZ as peroxidase (POD) and catalase (CAT) mimetics to elucidate their lifespan and underlying mechanisms. Unlike our previously reported Fe 3 O 4 nanozymes, which exhibit depletable POD-like activity, the POD and CAT-like activities of PBNZ not only persist but slightly enhance over prolonged catalysis. We demonstrate that the irreversible oxidation of PBNZ significantly promotes catalysis, leading to self-increasing catalytic activities. The catalytic process of the pre-oxidized PBNZ can be initiated through either the conduction band pathway or the valence band pathway. In summary, we reveal that PBNZ follows a dual-path electron transfer mechanism during the POD and CAT-like catalysis, offering the advantage of a long service life. Sustained catalytic performance wound benefit the applications of nanozymes, but the catalytic activity of some nanozymes depletes with time. Here the authors report Prussian blue nanozymes that exhibit self-increasing catalytic activity and elucidate the underlying catalytic mechanisms.

Denture defects affect patients’ aesthetic appearance and masticatory function, thus reducing their quality of life. There are many ways to repair denture defects, among which removable partial dentures are a basic and widely used method. The purpose of this study was to compare the clinical performance of Bio-HPP and Vitallium frameworks in the restoration of free-end removable partial dentures. 80 patients with free-end removable partial dentures treated at the Stomatology Hospital of Xi’an jiaotong university from January 2022 to March 2023 were randomly divided into two groups. 40 patients in the control group received Vitallium frameworks and 40 patients in the observation group received Bio-HPP frameworks. The abutment tooth mobility, gingival index, and patient satisfaction after one year of restoration were compared and analyzed between the two groups using an Independent T-test. P  < 0.05 was considered significant. All our experiments were carried out in accordance with relevant standards and regulations of Stomatology Hospital of Xi 'an Jiaotong University. After 1-year follow-up, in terms of aesthetics, comfort, and patient satisfaction, Bio-HPP was significantly superior to Vitallium frameworks, whereas the opposite was true for denture stability ( P  < 0.05). Besides, there were no significant differences in the mobility of abutment teeth and gingival index between Bio-HPP and Vitallium frameworks ( P  > 0.05). Both Bio-HPP and Vitallium frameworks can be used in restoring free-end removable partial dentures and the performance of the restorations was clinically acceptable. However, Bio-HPP has unique advantages in terms of aesthetics and comfort.

The activity of nanomaterials (NMs) in catalytically scavenging superoxide anions mimics that of superoxide dismutase (SOD). Although dozens of NMs have been demonstrated to possess such activity, the underlying principles are unclear, hindering the discovery of NMs as the novel SOD mimics. In this work, we use density functional theory calculations to study the thermodynamics and kinetics of the catalytic processes, and we develop two principles, namely, an energy level principle and an adsorption energy principle, for the activity. The first principle quantitatively describes the role of the intermediate frontier molecular orbital in transferring electrons for catalysis. The second one quantitatively describes the competition between the desired catalytic reaction and undesired side reactions. The ability of the principles to predict the SOD-like activities of metal-organic frameworks were verified by experiments. Both principles can be easily implemented in computer programs to computationally screen NMs with the intrinsic SOD-like activity. A general predicting theory for superoxide-dismutase mimicking nanomaterials is currently lacking. The present manuscript reports a density functional theory study on the superoxides dismutase-like activity of nanomaterials based on their electronic band structures and surface adsorption energies.

Despite advancements in occupational health and safety (OHS) management, high-risk industries in China continue to report a significant number of fatal accidents, underscoring systemic challenges in protecting the well-being of workers while supporting economic development. This study analyzed 22 years of historical data on OHS incidents, labor dynamics, and economic growth in China’s high-risk industries via multiple regression and network analysis methods. The findings reveal hierarchical influence relationships, with coal mine fatalities emerging as critical upstream factors and transportation fatalities and national labor force dynamics emerging as key downstream factors. Notably, the study reveals a negative correlation between GDP and fatal workplace incidents: for every 0.461 trillion CNY increase in GDP, production safety accident deaths decrease by one. Conversely, each safety accident resulted in 1.052 coal mine fatalities and 0.153 cases of occupational disease. These results offer a novel quantitative perspective on the interplay between economic growth and workplace safety. The study’s models provide practical guidance for enhancing the effectiveness of OHS prevention and control efforts, contributing to sustainable economic and public health outcomes.

Three evident and meaningful characteristics of disruptive technology are the zeroing effect that causes sustaining technology useless for its remarkable and unprecedented progress, reshaping the landscape of technology and economy, and leading the future mainstream of technology system, all of which have profound impacts and positive influences. The identification of disruptive technology is a universally difficult task. Therefore, this paper aims to enhance the technical relevance of potential disruptive technology identification results and improve the granularity and effectiveness of potential disruptive technology identification topics. According to the life cycle theory, dividing the time stage, then constructing and analyzing the dynamic of technology networks to identify potential disruptive technology. Thereby, using the Latent Dirichlet Allocation (LDA) topic model further to clarify the topic content of potential disruptive technologies. This paper takes the large civil unmanned aerial vehicles (UAVs) as an example to prove the feasibility and effectiveness of the model. The results show that the potential disruptive technology in this field is the data acquisition, main equipment, and ground platform intelligence.