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  To investigate the influence of dust produced by multi-dust sources at a fully mechanized mining face with a large mining height on the safety conditions in a coal mine, the No. 22305 fully mechanized mining face of the Bulianta coal mine was considered as the research object in this study, and the space–time evolution of dust was analyzed with computational fluid dynamics (CFD). The wind flow simulation results show that the distribution law of wind flow is mainly affected by the structure of the roadway, and the speed and direction of the wind flow change greatly while passing by corners and through large-scale equipment. The dust generation and pollution diffusion laws with respect to time and space were investigated based on simulations of dust production due to 5-s, 30-s, and 60-s coal cutting, continuous coal cutting, and hydraulic support shifting. The space–time evolution law under different dust-producing times shows the transportation and diffusion procedure of dust under the wind flow; the dust-generated via coal mining and shifting were superposed on the downwind side and a 36-m-long dust belt was formed, which filled the coal mining space; the dust concentration in the breathing zone 120 m downwind the front drum had a dust concentration higher than 1700 mg/m 3 , this was the crucial dust-proof area, and effective dust reduction methods should be addressed.

A convection-type air curtain dust control system and method were proposed to effectively control the high dust concentrations generated during the operation of coal miners and hydraulic supports and to reduce the dust concentration in the entire working space of longwall work surfaces, and the effectiveness of air curtain dust control during single process operation was investigated through numerical simulation. The results showed that when the miner was working alone, there was a significant difference in the concentration distribution inside and outside the dust-proof air curtain, with significantly lower dust concentrations in the area where the miner drivers were operating compared to both sides, with an average dust mass concentration of around 420 mg/m 3 . Dust concentrations increased to about 700 mg/m 3 , but large amounts of dust were prevented from diffusing downwind. This indicates that the dust reduction effect is more pronounced after the equipment is opened, which can improve the working environment and reduce the probability of dust combustion and explosion accidents.

The leakage of small holes in the buried CO 2 pipeline is not easy to detect, which leads to the problem of the inability to accurately trace the source of the pipeline repair in the later stage. This paper designs and builds an experimental system to simulate the leakage of buried CO 2 pipelines and conducts experiments on the leakage of small holes in buried CO 2 pipelines to investigate the changes in the surrounding soil temperature when they leak. The results showed that the type of movement of CO 2 in porous media after it is released from the leak is “funneling.” At a distance of about 50 mm from the horizontal, the temperature difference in the horizontal surface is smallest at the 50 cm closest to the vertical distance of the leak, while at a distance of 225 mm from the horizontal, the temperature difference in the horizontal surface is largest at the 70 cm farthest from the vertical distance of the leak. The research results can provide a theoretical basis for the later development of technologies that can quickly locate the leakage points of buried CO 2 pipelines and accurately determine their leakage status.

The leakage of small holes in the buried CO pipeline is not easy to detect, which leads to the problem of the inability to accurately trace the source of the pipeline repair in the later stage. This paper designs and builds an experimental system to simulate the leakage of buried CO pipelines and conducts experiments on the leakage of small holes in buried CO pipelines to investigate the changes in the surrounding soil temperature when they leak. The results showed that the type of movement of CO in porous media after it is released from the leak is \"funneling.\" At a distance of about 50 mm from the horizontal, the temperature difference in the horizontal surface is smallest at the 50 cm closest to the vertical distance of the leak, while at a distance of 225 mm from the horizontal, the temperature difference in the horizontal surface is largest at the 70 cm farthest from the vertical distance of the leak. The research results can provide a theoretical basis for the later development of technologies that can quickly locate the leakage points of buried CO pipelines and accurately determine their leakage status.

Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of liver transplantation. Transmembrane member 16A (TMEM16A), a component of hepatocyte Ca 2+ -activated chloride channel, has been implicated in a variety of liver diseases. However, its role in hepatic I/R injury remains unknown. Here, mice with hepatocyte-specific TMEM16A knockout or overexpression were generated to examine the effect of TMEM16A on hepatic I/R injury. TMEM16A expression increased in liver samples from patients and mice with I/R injury, which was correlated with liver damage progression. Hepatocyte-specific TMEM16A knockout alleviated I/R-induced liver damage in mice, ameliorating inflammation and ferroptotic cell death. However, mice with hepatic TMEM16A overexpression showed the opposite phenotype. In addition, TMEM16A ablation decreased inflammatory responses and ferroptosis in hepatocytes upon hypoxia/reoxygenation insult in vitro, whereas TMEM16A overexpression promoted the opposite effects. The ameliorating effects of TMEM16A knockout on hepatocyte inflammation and cell death were abolished by chemically induced ferroptosis, whereas chemical inhibition of ferroptosis reversed the potentiated role of TMEM16A in hepatocyte injury. Mechanistically, TMEM16A interacted with glutathione peroxidase 4 (GPX4) to induce its ubiquitination and degradation, thereby enhancing ferroptosis. Disruption of TMEM16A–GPX4 interaction abrogated the effects of TMEM16A on GPX4 ubiquitination, ferroptosis, and hepatic I/R injury. Our results demonstrate that TMEM16A exacerbates hepatic I/R injury by promoting GPX4-dependent ferroptosis. TMEM16A–GPX4 interaction and GPX4 ubiquitination are therefore indispensable for TMEM16A-regulated hepatic I/R injury, suggesting that blockades of TMEM16A–GPX4 interaction or TMEM16A inhibition in hepatocytes may represent promising therapeutic strategies for acute liver injury.

Bicycle riding requires a high standard width and continuity of lanes, as an appropriate width directly improves the service level of the lanes. Therefore, the width of bicycle lanes should be designed considering the characteristics of the bicycle traffic flow and the actual conditions of an area. In order to explore the relationship between bicycle traffic flow characteristics and lane width, this study references the vehicle traffic flow model and introduces the concept of bicycle traffic flow width, defined as the average width of bicycle traffic flow over a certain distance in a unit of time. Based on measured data, this study analyzes the relationships among bicycle traffic flow, lane width, and other parameters. The research results show that when the bicycle lane width is between 2.0 and 3.4 m, there is a clear linear relationship between the speed of bicycle traffic flow and the traffic flow width, with bicycle traffic flow width increasing as speed increases. Furthermore, overly wide bicycle lanes can result in more instances of bicycle over-speeding. These findings will guide the design of bicycle lanes.

After the temporary end of COVID-19 in China in February 2023, the influenza epidemic peaked in March across many Chinese places. We recruited a total of 258 all-age subjects presenting influenza-like illness (ILI) in Shihezi city, China from January 1 to March 16, 2023, and tested for influenza virus infection. Using a test-negative design, we assessed influenza vaccine effectiveness (VE) of 56.3% (95% CrI: 13.6, 73.6) against medically attended, influenza illness during the delayed 2022/23 influenza epidemic. The findings contributed to the continuous monitoring of the influenza vaccine performance across the world, especially in the “post-COVID” pandemic era.

This research aims to address the limited consideration given to non-motorized transport facilities in current studies on shared bike travel demand forecasting. This study is the first to propose a method that applies complete citywide non-motorized facility data to predict bike-sharing demand. This study employs a multiscale geographically weighted regression (MGWR) model to examine the effects of non-motorized transport facility conditions, quantity of intersections, and land use per unit area on riding demand at various spatial scales. The results of comparison experiments reveal that riding demand is substantially affected by non-motorized transport facilities and the quantity of intersections.

At present, there is a research gap concerning the specific functions and mechanisms of the Notch gene family and its signaling pathway in jawless vertebrates. In this study, we identified a Notch1 homologue (Lr. Notch1) in the Lethenteron reissneri database. Through bioinformatics analysis, we identified Lr. Notch1 as the likely common ancestor gene of the Notch gene family in higher vertebrates, indicating a high degree of conservation in the Notch gene family and its signaling pathways. To validate the biological function of Lr. Notch1, we conducted targeted silencing of Lr. Notch1 in L. reissneri and analyzed the resultant gene expression profile before and after silencing using transcriptome analysis. Our findings revealed that the silencing of Lr. Notch1 resulted in differential expression of pathways and genes associated with signal transduction, immune regulation, and metabolic regulation, mirroring the biological function of the Notch signaling pathway in higher vertebrates. This article systematically elucidated the origin and evolution of the Notch gene family while also validating the biological function of Lr. Notch1. These insights offer valuable clues for understanding the evolution of the Notch signaling pathway and establish a foundation for future research on the origin of the Notch signaling pathway, as well as its implications in human diseases and immunomodulation.

The metabotropic glutamate receptor (mGluR, GRM) family is involved in multiple signaling pathways and regulates neurotransmitter release. However, the evolutionary history, distribution, and function of the mGluRs family in lampreys have not been determined. Therefore, we identified the mGluRs gene family in the genome of Lethenteron reissneri, which has been conserved throughout vertebrate evolution. We confirmed that Lr-GRM3, Lr-GRM5, and Lr-GRM7 encode three types of mGluRs in lamprey. Additionally, we investigated the distribution of Lr-GRM3 within this species by qPCR and Western blotting. Furthermore, we conducted RNA sequencing to investigate the molecular function of Lr-GRM3 in lamprey. Our gene expression profile revealed that, similar to that in jawed vertebrates, Lr-GRM3 participates in multiple signal transduction pathways and influences synaptic excitability in lampreys. Moreover, it also affects intestinal motility and the inflammatory response in lampreys. This study not only enhances the understanding of mGluRs’ gene evolution but also highlights the conservation of GRM3’s role in signal transduction while expanding our knowledge of its functions specifically within lampreys. In summary, our experimental findings provide valuable insights for studying both the evolution and functionality of the mGluRs family.