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result(s) for
"Yoo, Taeeun"
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You are a lion! : and other fun yoga poses
\"Children pretend to be many different animals as they do various yoga poses\"-- Provided by publisher.
Book
Selenium inhibits growth of trastuzumab-resistant human breast cancer cells via downregulation of Akt and beclin-1
The response rate to treatment with trastuzumab (Tz), a recombinant humanized anti-HER2 monoclonal antibody, is only 12–34% despite demonstrated effectiveness on improving the survival of patients with HER2-positive breast cancers. Selenium has an antitumor effect against cancer cells and can play a cytoprotective role on normal cells. This study investigated the effect of selenium on HER2-positive breast cancer cells and the mechanism in relation to the response of the cells to Tz. HER2-positive breast cancer cell lines, SK-BR-3 as trastuzumab-sensitive cells, and JIMT-1 as Tz-resistant cells were treated with Tz and sodium selenite (selenite). Cell survival rates and expression of Her2, Akt, and autophagy-related proteins, including LC3B and beclin 1, in both cell lines 72 h after treatment were evaluated. Significant cell death was induced at different concentrations of selenite in both cell lines. A combined effect of selenite and Tz at 72 h was similar to or significantly greater than each drug alone. The expression of phosphorylated Akt (p-Akt) was decreased in JIMT-1 after combination treatment compared to that after only Tz treatment, while p-Akt expression was increased in SK-BR-3. The expression of beclin1 increased particularly in JIMT-1 after only Tz treatment and was downregulated by combination treatment. These results showed that combination of Tz and selenite had an antitumor effect in Tz-resistant breast cancer cells through downregulation of phosphorylated Akt and beclin1-related autophagy. Selenite might be a potent drug to treat Tz-resistant breast cancer by several mechanisms.
Journal Article
You are a lion! : and other fun yoga poses
Children pretend to be many different animals as they do various yoga poses.
BOOK
Therapeutic potential of anti-ErbB3 chimeric antigen receptor natural killer cells against breast cancer
ErbB3 is markedly overexpressed in breast cancer cells and is associated with resistance and metastasis. Additionally, ErbB3 expression levels are positively correlated with low densities of tumor-infiltrating lymphocytes, a marker of poor prognosis. Consequently, ErbB3 is a promising therapeutic target for cancer immunotherapy. Here, we report the generation of ErbB3-targeted chimeric antigen receptor (CAR)-modified natural killer (NK) cells by transducing cord blood-derived primary NK cells using vsv-g envelope-pseudotyped lentiviral vectors. Transduced cells displayed stable CAR-expressing activity and increased cytotoxicity against ErbB3-positive breast cancer cell lines. Furthermore, anti-ErbB3 (aErbB3) CAR-NK cells strongly reduced the tumor burden in the SK-BR-3 xenograft mouse model without observable side effects. These findings underscore the potential of aErbB3 CAR-NK cells as targeted immunotherapy for ErbB3-positive breast cancer, suggesting a promising alternative to conventional treatments.
Journal Article
Round
\"Sidman invites readers to search their worlds for round objects in nature. Illustrated with ... art by ... Taeeun Yoo, this fresh celebration shows why we love this shape best\"-- Provided by publisher.
Book
So many days
Through rhythmic text, a parent reflects on the options and opportunities possible in a beloved child's future.
Book
Strictly no elephants
A boy is excluded from joining his friends' pet club because of his unusual pet.
Book
Only a witch can fly
A young girl who has always wanted to fly like a witch on a broom tries and tries again one special night, with her brother and black cat at her side and an owl watching over all.
Kitten and the night watchman
As he makes his rounds, a night watchman hears birds calling, insects buzzing, and vehicles roaring by, while a stray kitten keeps him company.
Book