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هذا الكتاب مخصص للأطفال يستهدف الطفولة المبكرة وتعمل علي اسثمار الطفل في بناء المهارات المختلفة المرتبطة بالخيال والأبتكار وقوة الشخصية والبحث عن حلول إبداعية ويستمد الطفل الكثير من العلم والمعرفة والمعلومات من المنهج السلوكي التربوي رائع يعلم الطفل كيف يستخلص من مشكلاته وكيف يبني شخصيته بشكل مميز ويعطي المربي حلولا لحل مشكلات أبنه تعنيه عن تجاوز الأزمة وإنهائها.

Inspired by recent measurement of possible fully charmed tetraquarks in LHCb Collaboration, we investigate the mass spectra of fully heavy tetraquarks QQQ¯Q¯ in an extended relativized quark model. Our estimations indicate that the broad structure around 6.4 GeV should contain one or more ground states for ccc¯c¯ tetraquarks, while the narrow structure near 6.9 GeV can be categorized as the first radial excitation of ccc¯c¯ system. Moreover, with the wave functions of the tetraquarks and mesons, the strong decays of tetraquarks into heavy quarkonium pair are qualitatively discussed, which can be further checked by the LHCb and CMS Collaborations.

In this paper, the Hawking–Page phase transitions between the black holes and thermal anti-de Sitter (AdS) space are studied with the Gauss–Bonnet term in the extended phase space, in which the varying cosmological constant plays the role of an effective thermodynamic pressure. The Gauss–Bonnet term exhibits its effects via introducing the corrections to the black hole entropy and Gibbs free energy. The global phase structures, especially the phase transition temperature THP and the Gibbs free energy G, are systematically investigated, first for the Schwarzschild–AdS black holes and then for the charged and rotating AdS black holes in the grand canonical ensembles, with both analytical and numerical methods. It is found that there are terminal points in the coexistence lines, and THP decreases at large electric potentials and angular velocities and also decreases with the Gauss–Bonnet coupling constant α.

Previous literature suggests that higher ambient temperature may play a role in increasing the risk of suicide. However, no multi-country study has explored the shape of the association and the role of moderate and extreme heat across different locations. We examined the short-term temperature-suicide relationship using daily time-series data collected for 341 locations in 12 countries for periods ranging from 4 to 40 y. We conducted a two-stage meta-analysis. First, we performed location-specific time-stratified case-crossover analyses to examine the temperature-suicide association for each location. Then, we used a multivariate meta-regression to combine the location-specific lag-cumulative nonlinear associations across all locations and by country. A total of 1,320,148 suicides were included in this study. Higher ambient temperature was associated with an increased risk of suicide in general, and we observed a nonlinear association (inverted J-shaped curve) with the highest risk at 27°C. The relative risk (RR) for the highest risk was 1.33 (95% CI: 1.30, 1.36) compared with the risk at the first percentile. Country-specific results showed that the nonlinear associations were more obvious in northeast Asia (Japan, South Korea, and Taiwan). The temperature with the highest risk of suicide ranged from the 87th to 88th percentiles in the northeast Asian countries, whereas this value was the 99th percentile in Western countries (Canada, Spain, Switzerland, the UK, and the United States) and South Africa, where nearly linear associations were estimated. The country-specific RRs ranged from 1.31 (95% CI: 1.19, 1.44) in the United States to 1.65 (95% CI: 1.40, 1.93) in Taiwan, excluding countries where the results were substantially uncertain. Our findings showed that the risk of suicide increased with increasing ambient temperature in many countries, but to varying extents and not necessarily linearly. This temperature-suicide association should be interpreted cautiously, and further evidence of the relationship and modifying factors is needed. https://doi.org/10.1289/EHP4898.

Primordial black holes (PBHs) are a promising candidate for dark matter, as they can form in the very early universe without invoking new particle physics. This work explores PBH formation within a curvaton scenario featuring an ultraslow-roll (USR) phase. An inflaton–curvaton mixed field model is presented, where the inflaton drives early inflation and then transits into the USR phase, amplifying the small-scale curvature perturbation. During inflation, the curvaton generates entropy perturbation, which later converts into curvature perturbation after the curvaton decays in the radiation-dominated era. Using the δ N formalism, we compute the power spectrum of the total primordial curvature perturbation and analyze the relevant non-Gaussianity. Our results show that adding a curvaton field not only has a significant impact on primordial non-Gaussianity, but also introduces more complex inflationary dynamics, even saving the inflaton potentials that generate too low scalar spectral indices. Our model can produce PBHs with mass around 10 - 14 M ⊙ that account for all dark matter, while remaining consistent with current observational constraints.

Background/Aims: Circular RNAs (circRNAs), a type of RNA that is widely expressed in human cells, have essential roles in the development and progression of cancer. CircRNAs contain microRNA (miRNA) binding sites and can function as miRNA sponges to regulate gene expression by removing the inhibitory effect of an miRNA on its target gene. Methods: We used the bioinformatics software TargetScan and miRanda to predict circRNA-miRNA and miRNAi-Mrna interactions. Rate of inhibiting of proliferation was measured using a WST-8 cell proliferation assay. Clone formation ability was assessed with a clone formation inhibition test. Cell invasion and migration capacity was evaluated by performing a Transwell assay. Relative gene expression was assessed using quantitative real-time polymerase chain reaction and relative protein expression levels were determined with western blotting. circRNA and miRNA interaction was confirmed by dual-luciferase reporter and RNA-pull down assays. Results: In the present study, the miRNA hsa-miR-21-5p was a target of circRNA-ACAP2, and T lymphoma invasion and metastasis protein 1 (Tiam1) was identified as a target gene of hsa-miR-21-5p. CircRNA-ACAP2 and Tiam1 were shown to be highly expressed in colon cancer tissue and colon cancer SW480 cells, but miR-21-5p was expressed at a low level. SW480 cell proliferation was suppressed when the expression of circRNA-ACAP2 and Tiam1 was decreased and the expression of miR-21-5p was increased in vivo and in vitro. SW480 cell migration and invasion were also inhibited under the same circumstance. The circRNA-ACAP2 interaction regulated the expression of miR-21-5p, and miR-21-5p regulated the expression of Tiam1. Down-regulation of circRNA-ACAP2 promoted miR-21-5p expression, which further suppressed the transcription and translation of Tiam1. Conclusion: The present study shows that the circRNA-ACAP2/hsa-miR-21-5p/Tiam1 regulatory feedback circuit could affect the proliferation, migration, and invasion of colon cancer SW480 cells. This was probably due to the fact that circRNA-ACAP2 could act as a miRNA sponge to regulate Tiam1 expression by removing the inhibitory effect of miR-21-5p on Tiam1 expression. The results from this study have revealed new insights into the pathogenicity of colon cancer and may provide novel therapeutic targets for the treatment of colon cancer.

Modeling of the associations between mortality and air pollution data from 652 cities, mostly in the northern hemisphere, showed that concentrations of inhalable and fine particulate matter were associated with daily all-cause, cardiovascular, and respiratory mortality. An interactive map allows the reader to explore the geographic distribution of PM, and a Quick Take summarizes the findings in a short video.

Clonorchiasis, caused by Clonorchis sinensis ( C. sinensis ), is an important food-borne parasitic disease and one of the most common zoonoses. Currently, it is estimated that more than 200 million people are at risk of C. sinensis infection, and over 15 million are infected worldwide. C. sinensis infection is closely related to cholangiocarcinoma (CCA), fibrosis and other human hepatobiliary diseases; thus, clonorchiasis is a serious public health problem in endemic areas. This article reviews the current knowledge regarding the epidemiology, disease burden and treatment of clonorchiasis as well as summarizes the techniques for detecting C. sinensis infection in humans and intermediate hosts and vaccine development against clonorchiasis. Newer data regarding the pathogenesis of clonorchiasis and the genome, transcriptome and secretome of C. sinensis are collected, thus providing perspectives for future studies. These advances in research will aid the development of innovative strategies for the prevention and control of clonorchiasis.

Heatwaves are a critical public health problem. There will be an increase in the frequency and severity of heatwaves under changing climate. However, evidence about the impacts of climate change on heatwave-related mortality at a global scale is limited. We collected historical daily time series of mean temperature and mortality for all causes or nonexternal causes, in periods ranging from January 1, 1984, to December 31, 2015, in 412 communities within 20 countries/regions. We estimated heatwave-mortality associations through a two-stage time series design. Current and future daily mean temperature series were projected under four scenarios of greenhouse gas emissions from 1971-2099, with five general circulation models. We projected excess mortality in relation to heatwaves in the future under each scenario of greenhouse gas emissions, with two assumptions for adaptation (no adaptation and hypothetical adaptation) and three scenarios of population change (high variant, median variant, and low variant). Results show that, if there is no adaptation, heatwave-related excess mortality is expected to increase the most in tropical and subtropical countries/regions (close to the equator), while European countries and the United States will have smaller percent increases in heatwave-related excess mortality. The higher the population variant and the greenhouse gas emissions, the higher the increase of heatwave-related excess mortality in the future. The changes in 2031-2080 compared with 1971-2020 range from approximately 2,000% in Colombia to 150% in Moldova under the highest emission scenario and high-variant population scenario, without any adaptation. If we considered hypothetical adaptation to future climate, under high-variant population scenario and all scenarios of greenhouse gas emissions, the heatwave-related excess mortality is expected to still increase across all the countries/regions except Moldova and Japan. However, the increase would be much smaller than the no adaptation scenario. The simple assumptions with respect to adaptation as follows: no adaptation and hypothetical adaptation results in some uncertainties of projections. This study provides a comprehensive characterisation of future heatwave-related excess mortality across various regions and under alternative scenarios of greenhouse gas emissions, different assumptions of adaptation, and different scenarios of population change. The projections can help decision makers in planning adaptation and mitigation strategies for climate change.