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طائر في السحاب
هذا الكتاب مخصص للأطفال يستهدف الطفولة المبكرة وتعمل علي اسثمار الطفل في بناء المهارات المختلفة المرتبطة بالخيال والأبتكار وقوة الشخصية والبحث عن حلول إبداعية ويستمد الطفل الكثير من العلم والمعرفة والمعلومات من المنهج السلوكي التربوي رائع يعلم الطفل كيف يستخلص من مشكلاته وكيف يبني شخصيته بشكل مميز ويعطي المربي حلولا لحل مشكلات أبنه تعنيه عن تجاوز الأزمة وإنهائها.
BOOK
Masses of fully heavy tetraquarks QQQ¯Q¯ in an extended relativized quark model
Inspired by recent measurement of possible fully charmed tetraquarks in LHCb Collaboration, we investigate the mass spectra of fully heavy tetraquarks
Q
Q
Q
¯
Q
¯
in an extended relativized quark model. Our estimations indicate that the broad structure around 6.4 GeV should contain one or more ground states for
c
c
c
¯
c
¯
tetraquarks, while the narrow structure near 6.9 GeV can be categorized as the first radial excitation of
c
c
c
¯
c
¯
system. Moreover, with the wave functions of the tetraquarks and mesons, the strong decays of tetraquarks into heavy quarkonium pair are qualitatively discussed, which can be further checked by the LHCb and CMS Collaborations.
Journal Article
The Hawking–Page phase transitions in the extended phase space in the Gauss–Bonnet gravity
In this paper, the Hawking–Page phase transitions between the black holes and thermal anti-de Sitter (AdS) space are studied with the Gauss–Bonnet term in the extended phase space, in which the varying cosmological constant plays the role of an effective thermodynamic pressure. The Gauss–Bonnet term exhibits its effects via introducing the corrections to the black hole entropy and Gibbs free energy. The global phase structures, especially the phase transition temperature
T
HP
and the Gibbs free energy
G
, are systematically investigated, first for the Schwarzschild–AdS black holes and then for the charged and rotating AdS black holes in the grand canonical ensembles, with both analytical and numerical methods. It is found that there are terminal points in the coexistence lines, and
T
HP
decreases at large electric potentials and angular velocities and also decreases with the Gauss–Bonnet coupling constant
α
.
Journal Article
Suicide and Ambient Temperature: A Multi-Country Multi-City Study
Previous literature suggests that higher ambient temperature may play a role in increasing the risk of suicide. However, no multi-country study has explored the shape of the association and the role of moderate and extreme heat across different locations.
We examined the short-term temperature-suicide relationship using daily time-series data collected for 341 locations in 12 countries for periods ranging from 4 to 40 y.
We conducted a two-stage meta-analysis. First, we performed location-specific time-stratified case-crossover analyses to examine the temperature-suicide association for each location. Then, we used a multivariate meta-regression to combine the location-specific lag-cumulative nonlinear associations across all locations and by country.
A total of 1,320,148 suicides were included in this study. Higher ambient temperature was associated with an increased risk of suicide in general, and we observed a nonlinear association (inverted J-shaped curve) with the highest risk at 27°C. The relative risk (RR) for the highest risk was 1.33 (95% CI: 1.30, 1.36) compared with the risk at the first percentile. Country-specific results showed that the nonlinear associations were more obvious in northeast Asia (Japan, South Korea, and Taiwan). The temperature with the highest risk of suicide ranged from the 87th to 88th percentiles in the northeast Asian countries, whereas this value was the 99th percentile in Western countries (Canada, Spain, Switzerland, the UK, and the United States) and South Africa, where nearly linear associations were estimated. The country-specific RRs ranged from 1.31 (95% CI: 1.19, 1.44) in the United States to 1.65 (95% CI: 1.40, 1.93) in Taiwan, excluding countries where the results were substantially uncertain.
Our findings showed that the risk of suicide increased with increasing ambient temperature in many countries, but to varying extents and not necessarily linearly. This temperature-suicide association should be interpreted cautiously, and further evidence of the relationship and modifying factors is needed. https://doi.org/10.1289/EHP4898.
Journal Article
Primordial black holes from the ultraslow-roll phase in the inflaton–curvaton mixed field inflation
Primordial black holes (PBHs) are a promising candidate for dark matter, as they can form in the very early universe without invoking new particle physics. This work explores PBH formation within a curvaton scenario featuring an ultraslow-roll (USR) phase. An inflaton–curvaton mixed field model is presented, where the inflaton drives early inflation and then transits into the USR phase, amplifying the small-scale curvature perturbation. During inflation, the curvaton generates entropy perturbation, which later converts into curvature perturbation after the curvaton decays in the radiation-dominated era. Using the
δ
N
formalism, we compute the power spectrum of the total primordial curvature perturbation and analyze the relevant non-Gaussianity. Our results show that adding a curvaton field not only has a significant impact on primordial non-Gaussianity, but also introduces more complex inflationary dynamics, even saving the inflaton potentials that generate too low scalar spectral indices. Our model can produce PBHs with mass around
10
-
14
M
⊙
that account for all dark matter, while remaining consistent with current observational constraints.
Journal Article
Ambient particulate air pollution and daily mortality in 652 cities
BACKGROUND : The systematic evaluation of the results of time-series studies of air pollution is challenged by differences in model specification and publication bias. METHODS : We evaluated the associations of inhalable particulate matter (PM) with an aerodynamic diameter of 10 μm or less (PM10) and fine PM with an aerodynamic diameter of 2.5 μm or less (PM2.5) with daily all-cause, cardiovascular, and respiratory mortality across multiple countries or regions. Daily data on mortality and air pollution were collected from 652 cities in 24 countries or regions. We used overdispersed generalized additive models with random-effects meta-analysis to investigate the associations. Two-pollutant models were fitted to test the robustness of the associations. Concentration–response curves from each city were pooled to allow global estimates to be derived. RESULTS : On average, an increase of 10 μg per cubic meter in the 2-day moving average of PM10 concentration, which represents the average over the current and previous day, was associated with increases of 0.44% (95% confidence interval [CI], 0.39 to 0.50) in daily all-cause mortality, 0.36% (95% CI, 0.30 to 0.43) in daily cardiovascular mortality, and 0.47% (95% CI, 0.35 to 0.58) in daily respiratory mortality. The corresponding increases in daily mortality for the same change in PM2.5 concentration were 0.68% (95% CI, 0.59 to 0.77), 0.55% (95% CI, 0.45 to 0.66), and 0.74% (95% CI, 0.53 to 0.95). These associations remained significant after adjustment for gaseous pollutants. Associations were stronger in locations with lower annual mean PM concentrations and higher annual mean temperatures. The pooled concentration–response curves showed a consistent increase in daily mortality with increasing PM concentration, with steeper slopes at lower PM concentrations. CONCLUSIONS : Our data show independent associations between short-term exposure to PM10 and PM2.5 and daily all-cause, cardiovascular, and respiratory mortality in more than 600 cities across the globe. These data reinforce the evidence of a link between mortality and PM concentration established in regional and local studies.
Journal Article
Energy-transfer-enabled photocatalytic transformations of aryl thianthrenium salts
Aryl thianthrenium salts are valuable in photocatalysis but traditionally require external electron donors for activation. This study introduces an energy transfer (EnT) strategy for the activation of aryl thianthrenium salts using 2,3,4,5,6-penta(carbazol-9-yl)benzonitrile (5CzBN) as a metal-free photocatalyst, eliminating the need for external donors. Utilizing this EnT approach, we achieve C–H deuteration of arenes under visible light with CDCl
3
as a deuterium source to synthesize various deuterated aromatic compounds, including important natural products and pharmaceuticals. Additionally, this strategy enables diverse functionalizations including borylation, arylation, cyanation, and selenylation, enhancing the applicability of aryl sulfonium salts in environmentally friendly photocatalysis.
Aryl thianthrenium salts are valuable in photocatalysis but traditionally require external electron donors for activation. Herein, the authors report an energy transfer strategy for the activation of aryl thianthrenium salts, eliminating the need for external donors.
Journal Article
The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells
Background/Aims: Circular RNAs (circRNAs), a type of RNA that is widely expressed in human cells, have essential roles in the development and progression of cancer. CircRNAs contain microRNA (miRNA) binding sites and can function as miRNA sponges to regulate gene expression by removing the inhibitory effect of an miRNA on its target gene. Methods: We used the bioinformatics software TargetScan and miRanda to predict circRNA-miRNA and miRNAi-Mrna interactions. Rate of inhibiting of proliferation was measured using a WST-8 cell proliferation assay. Clone formation ability was assessed with a clone formation inhibition test. Cell invasion and migration capacity was evaluated by performing a Transwell assay. Relative gene expression was assessed using quantitative real-time polymerase chain reaction and relative protein expression levels were determined with western blotting. circRNA and miRNA interaction was confirmed by dual-luciferase reporter and RNA-pull down assays. Results: In the present study, the miRNA hsa-miR-21-5p was a target of circRNA-ACAP2, and T lymphoma invasion and metastasis protein 1 (Tiam1) was identified as a target gene of hsa-miR-21-5p. CircRNA-ACAP2 and Tiam1 were shown to be highly expressed in colon cancer tissue and colon cancer SW480 cells, but miR-21-5p was expressed at a low level. SW480 cell proliferation was suppressed when the expression of circRNA-ACAP2 and Tiam1 was decreased and the expression of miR-21-5p was increased in vivo and in vitro. SW480 cell migration and invasion were also inhibited under the same circumstance. The circRNA-ACAP2 interaction regulated the expression of miR-21-5p, and miR-21-5p regulated the expression of Tiam1. Down-regulation of circRNA-ACAP2 promoted miR-21-5p expression, which further suppressed the transcription and translation of Tiam1. Conclusion: The present study shows that the circRNA-ACAP2/hsa-miR-21-5p/Tiam1 regulatory feedback circuit could affect the proliferation, migration, and invasion of colon cancer SW480 cells. This was probably due to the fact that circRNA-ACAP2 could act as a miRNA sponge to regulate Tiam1 expression by removing the inhibitory effect of miR-21-5p on Tiam1 expression. The results from this study have revealed new insights into the pathogenicity of colon cancer and may provide novel therapeutic targets for the treatment of colon cancer.
Journal Article
Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control
Clonorchiasis, caused by
Clonorchis sinensis
(
C. sinensis
), is an important food-borne parasitic disease and one of the most common zoonoses. Currently, it is estimated that more than 200 million people are at risk of
C. sinensis
infection, and over 15 million are infected worldwide.
C. sinensis
infection is closely related to cholangiocarcinoma (CCA), fibrosis and other human hepatobiliary diseases; thus, clonorchiasis is a serious public health problem in endemic areas. This article reviews the current knowledge regarding the epidemiology, disease burden and treatment of clonorchiasis as well as summarizes the techniques for detecting
C. sinensis
infection in humans and intermediate hosts and vaccine development against clonorchiasis. Newer data regarding the pathogenesis of clonorchiasis and the genome, transcriptome and secretome of
C. sinensis
are collected, thus providing perspectives for future studies. These advances in research will aid the development of innovative strategies for the prevention and control of clonorchiasis.
Journal Article