Explore the vast range of titles available.

A modified Hayward black hole is a nonsingular black hole. It is proposed that it would form when the pressure generated by quantum gravity can stop matter’s collapse as the matter reaches the Planck density. Strong deflection gravitational lensing occurring nearby its event horizon might provide some clues of these quantum effects in its central core. We investigate observables of the strong deflection lensing, including angular separations, brightness differences and time delays between its relativistic images, and we estimate their values for the supermassive black hole in the Galactic center. We find that it is possible to distinguish the modified Hayward black hole from a Schwarzschild one, but it demands a very high resolution, beyond current stage.

Wazwaz Kaur Boussinesq (WKB) equation can effectively simulate the behavior of water waves in shallow water, including the nonlinear effect and dispersion phenomenon of waves, which is of great significance for understanding the dynamic process of ocean, river and other water bodies. To enrich the wave equation theory, the (3+1)-dimensional integer order derivative of WKB equation is changed to the fractional one with beta derivative. The current work deals with the fractional (3+1)-dimensional WKB equation for discussing its chaotic behavior and establishing some new analytic solutions. The chaotic properties of the equation are verified by the trend of evolution along with time, Lyapunov exponents and initial sensitivity analysis. And then complete discrimination system for polynomial method is applied to derive some trigonometric, hyperbolic, Jacobi elliptic and other solutions. The graphical demonstrations are provided for part of these solutions. From these visualized graphs, the solitary, periodic and quasi-periodic wave are shown and the effect of fractional derivatives on the equation can be seen intuitively.

Ample evidence suggests that hepatic macrophages play key roles in the injury and repair mechanisms during liver disease progression. There are two major populations of hepatic macrophages: the liver resident Kupffer cells and the monocyte-derived macrophages, which rapidly infiltrate the liver during injury. Under different disease conditions, the tissue microenvironmental cues of the liver critically influence the phenotypes and functions of hepatic macrophages. Furthermore, hepatic macrophages interact with multiple cells types in the liver, such as hepatocytes, neutrophils, endothelial cells, and platelets. These crosstalk interactions are of paramount importance in regulating the extents of liver injury, repair, and ultimately liver disease progression. In this review, we summarize the novel findings highlighting the impact of injury-induced microenvironmental signals that determine the phenotype and function of hepatic macrophages. Moreover, we discuss the role of hepatic macrophages in homeostasis and pathological conditions through crosstalk interactions with other cells of the liver.

The daily temperatures from observational data, NCEP-2 and CFSR reanalysis data all exhibit long-range correlation (LRC) characteristics, which provides a test bed for assessing the reliability of reanalysis data. In this study, the quality of the NCEP-2 and CFSR data in China are evaluated on the basis of the LRC characteristics of daily temperatures, including daily average temperature (DAT), daily maximum temperature (DMAT), daily minimum temperature (DMIT), and diurnal temperature range (DTR). Compared with the observations, the quality of NCEP-2 daily temperature is relatively good in central and eastern Northwest China, and most of central and eastern China, especially for NCEP-2 DMAT. However, the NCEP-2 reanalysis data as well as CFSR has a significant difference with the LRC of the observations in most of Sichuan, Qinghai-Tibet Plateau and some areas of southwestern Xinjiang at a significance level of Alpha = 0.05. In general, the LRC characteristics of NCEP-2 daily temperature perform better than that of CFSR data. As far as DAT is concerned, CFSR perform worse in central and eastern Northwest China, and better than NCEP-2 only in South China and eastern Jiangnan. The quality of the CFSR DMAT is worse than that of NCEP-2 in central and eastern Northwest China, western Inner Mongolia, and eastern China. The quality of NCEP-2 DMIT is better than CFSR in central and eastern Northwest China, most of Inner Mongolia, and is worse than it in most of South China and eastern Jiangnan. The reliability of the CFSR DTR is very low in most of China.

Background Insects exhibit remarkable resilience and maintain high levels of reproduction despite frequently encountering nutritional restriction. However, the mechanisms governing their adaptive reproductive strategies under nutrition-restricted conditions remain poorly understood. The German cockroach Blattella germanica , a widespread urban pest, exhibits remarkable reproductive capabilities even in domestic environments where food resources are frequently limited. Results In this study, we demonstrate that the ovary plays a crucial role in promoting vitellogenin biosynthesis and oocyte development under nutrition-restricted conditions through hemiovariectomy. Employing transcriptome analysis, RNAi screening, and fluorescence in situ hybridization, we identified an ovarian-enriched insulin-like peptide gene ( BgILP2 ) that is dramatically upregulated during low nutrition conditions. Repression of BgILP2 impairs vitellogenesis in the fat body through downregulation of p-AKT and p-ERK levels while simultaneously disrupting juvenile hormone synthesis, ultimately leading to delayed oocyte development under nutrient restriction. Furthermore, under low-nutrient conditions, repression of BgILP2 led to elevated circulating sugar levels, reduced lipid and glycogen storage, and a modest increase in the lifespan of female cockroaches. Conclusions The ovarian-enriched BgILP2 responds to nutritional stress and activates the insulin signaling pathway to sustain oocyte development under nutrient-restricted conditions. Furthermore, BgILP2 mediates energy allocation and prioritizes reproductive investment potentially at the expense of longevity, which reflects a tradeoff between reproduction and somatic maintenance under nutrient restriction. These findings provide novel insights into the molecular mechanisms and adaptive strategies that enable cockroaches to maintain reproductive success in food-limited environments. Graphical Abstract

Direct-current triboelectric nanogenerators arising from electrostatic breakdown can eliminate the bottleneck problem of air breakdown in conventional triboelectric nanogenerators, offering critical benefits of constant-current output, resistance to electromagnetic interference, and high output power density. Previous understanding is that its output characteristics are described by a capacitor-breakdown model or dictated by one or two discharge domains in direct-current triboelectric nanogenerators. Here, we demonstrate that the former holds only for ideal conditions and the latter cannot fully explain the dynamic process and output performance. We systematically image, define, and regulate three discharge domains in direct-current triboelectric nanogenerators, then a “cask model” is developed to bridge the cascaded-capacitor-breakdown dynamic model in ideal conditions and real outputs. Under its guidance, the output power is increased by an order of magnitude within a wide range of resistive loads. These unexplored discharge domains and optimization methods revolutionize the output performance and potential applications of direct-current triboelectric nanogenerators. Arising from contact electrification and electrostatic breakdown, DC triboelectric nanogenerators are a promising solution to the air breakdown bottleneck in conventional TENGs. Here, authors reveal and regulate three discharge domains enhancing the device output power by an order of magnitude.

Esophageal squamous dysplasia is believed to be the precursor lesion of esophageal squamous cell carcinoma (ESCC); however, the genetic evolution from dysplasia to ESCC remains poorly understood. Here, we applied multi-region whole-exome sequencing to samples from two cohorts, 45 ESCC patients with matched dysplasia and carcinoma samples, and 13 tumor-free patients with only dysplasia samples. Our analysis reveals that dysplasia is heavily mutated and harbors most of the driver events reported in ESCC. Moreover, dysplasia is polyclonal, and remarkable heterogeneity is often observed between tumors and their neighboring dysplasia samples. Notably, copy number alterations are prevalent in dysplasia and persist during the ESCC progression, which is distinct from the development of esophageal adenocarcinoma. The sharp contrast in the prevalence of the ‘two-hit’ event on TP53 between the two cohorts suggests that the complete inactivation of TP53 is essential in promoting the development of ESCC. The pathogenesis of oesophageal squamous cell carcinoma is a multi-step process but the genetic determinants behind this progression are unknown. Here the authors use multi-region exome sequencing to comprehensively investigate the genetic evolution of precursor dysplastic lesions and untransformed oesophagus.

Summary Brown planthopper (BPH, Nilaparvata lugens), a highly destructive insect pest, poses a serious threat to rice (Oryza sativa) production worldwide. Jasmonates are key phytohormones that regulate plant defences against BPH; however, the molecular link between jasmonates and BPH responses in rice remains largely unknown. Here, we discovered a Poaceae‐specific metabolite, mixed‐linkage β‐1,3;1,4‐d‐glucan (MLG), which contributes to jasmonate‐mediated BPH resistance. MLG levels in rice significantly increased upon BPH attack. Overexpressing OsCslF6, which encodes a glucan synthase that catalyses MLG biosynthesis, significantly enhanced BPH resistance and cell wall thickness in vascular bundles, whereas knockout of OsCslF6 reduced BPH resistance and vascular wall thickness. OsMYC2, a master transcription factor of jasmonate signalling, directly controlled the upregulation of OsCslF6 in response to BPH feeding. The AT‐rich domain of the OsCslF6 promoter varies in rice varieties from different locations and natural variants in this domain were associated with BPH resistance. MLG‐derived oligosaccharides bound to the plasma membrane‐anchored LECTIN RECEPTOR KINASE1 OsLecRK1 and modulated its activity. Thus, our findings suggest that the OsMYC2‐OsCslF6 module regulates pest resistance by modulating MLG production to enhance vascular wall thickness and OsLecRK1‐mediated defence signalling during rice‐BPH interactions.

The cost-effectiveness of nivolumab plus bevacizumab and chemotherapy for patients with advanced non-squamous non-small-cell lung-cancer (NSCLC) was uncleared yet. The current analysis aimed to evaluate the cost-effectiveness of nivolumab plus bevacizumab and chemotherapy compared with bevacizumab plus chemotherapy for patients with untreated non-squamous NSCLC in Chinese context. A partitioned survival model that simulated 3-week patients transition in 20-year time horizon was conducted to evaluate the economic value. The clinical data were obtained from TASUKI-52 trial, cost and utility values were gathered from the local charges and previously published studies. Sensitivity analyses were conducted to examine the robustness of the model results when parameters changed, subgroup analyses were also conducted to enhance the comprehensiveness of the analysis. Nivolumab plus bevacizumab and chemotherapy yielded an additional 0.90 QALYs with the marginal cost of $231,948.33, resulting in the incremental cost-effectiveness ratio (ICER) of $256,791.53 per additional quality-adjusted life-years (QALYs) gained, which higher than the Chinese willingness-to-pay (WTP) threshold of $39,057/QALY. Sensitivity analyses confirmed the robustness of the model outcomes. Subgroup analyses revealed that nivolumab plus bevacizumab and chemotherapy was unlikely to be the cost-effective option for all subgroups due to the unfavorable ICERs. Nivolumab plus bevacizumab and chemotherapy was unlikely to be the cost-effective first-line therapy for untreated advanced non-squamous NSCLC patients compared with bevacizumab plus chemotherapy from the perspective of Chinese health-care system.

Background Circular RNAs (circRNAs) mediate the infiltration of tumor-associated macrophages (TAMs) to facilitate carcinogenesis and development of various types of cancers. However, the role of circRNAs in regulating macrophages in prostate cancer (PCa) remains uncertain. Methods Differentially expressed circRNAs in PCa were identified by RNA sequencing. The expression of circSMARCC1 was recognized and evaluated using fluorescence in situ hybridization and quantitative real-time PCR. The oncogenic role of circSMARCC1 in PCa tumor proliferation and metastasis was investigated through a series of in vitro and in vivo assays. Finally, Western blot, biotin-labeled RNA pulldown, luciferase assay, rescue experiments, and co-culture experiments with TAMs were conducted to reveal the mechanistic role of circSMARCC1. Results CircSMARCC1 was dramatically up-regulated in PCa cells, plasma and tissues. Overexpression of circSMARCC1 promotes tumor proliferation and metastasis both in vitro and in vivo, whereas knockdown of circSMARCC1 exerts the opposite effects. Mechanistically, circSMARCC1 regulates the expression of CC-chemokine ligand 20 (CCL20) via sponging miR-1322 and activate PI3K-Akt signaling pathway involved in the proliferation and epithelial mesenchymal transformation. More importantly, high expression of circSMARCC1 was positively associated with colonization of CD68 + /CD163 + /CD206 + TAMs in tumor microenvironment. In addition, overexpression of circSMARCC1 facilitates the expression of CD163 in macrophages through the CCL20-CCR6 axis, induces TAMs infiltration and M2 polarization, thereby leading to PCa progression. Conclusions CircSMARCC1 up-regulates the chemokine CCL20 secretion by sponging miR-1322, which is involved in the crosstalk between tumor cells and TAMs by targeting CCL20/CCR6 signaling to promote progression of PCa.