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"Zhu, Cheng"
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The effect of self-limiting on the prevention and control of the diffuse COVID-19 epidemic with delayed and temporal-spatial heterogeneous
Background
The global spread of the novel coronavirus pneumonia is still continuing, and a new round of more serious outbreaks has even begun in some countries. In this context, this paper studies the dynamics of a type of delayed reaction-diffusion novel coronavirus pneumonia model with relapse and self-limiting treatment in a temporal-spatial heterogeneous environment.
Methods
First, focus on the self-limiting characteristics of COVID-19, incorporate the relapse and self-limiting treatment factors into the diffusion model, and study the influence of self-limiting treatment on the diffusion of the epidemic. Second, because the traditional Lyapunov stability method is difficult to determine the spread of the epidemic with relapse and self-limiting treatment, we introduce a completely different method, relying on the existence conditions of the exponential attractor of our newly established in the infinite-dimensional dynamic system to determine the diffusion of novel coronavirus pneumonia. Third, relapse and self-limiting treatment have led to a change in the structure of the delayed diffusion COVID-19 model, and the traditional basic reproduction number
R
0
no longer has threshold characteristics. With the help of the Krein-Rutman theorem and the eigenvalue method, we studied the threshold characteristics of the principal eigenvalue and found that it can be used as a new threshold to describe the diffusion of the epidemic.
Results
Our results prove that the principal eigenvalue
λ
∗
of the delayed reaction-diffusion COVID-19 system with relapse and self-limiting treatment can replace the basic reproduction number
R
0
to describe the threshold effect of disease transmission. Combine with the latest official data and the prevention and control strategies, some numerical simulations on the stability and global exponential attractiveness of the diffusion of the COVID-19 epidemic in China and the USA are given.
Conclusions
Through the comparison of numerical simulations, we find that self-limiting treatment can significantly promote the prevention and control of the epidemic. And if the free activities of asymptomatic infected persons are not restricted, it will seriously hinder the progress of epidemic prevention and control.
Journal Article
Never grow up
Everyone knows Jackie Chan. Whether it's from Rush Hour, Shanghai Noon, The Karate Kid, or Kung Fu Panda, Jackie is admired by generations of moviegoers for his acrobatic fighting style, comic timing, and mind-bending stunts. In 2016-after fifty-six years in the industry, over 200 films, and many broken bones-he received an honorary Academy Award for his lifetime achievement in film. But at 64 years-old, Jackie is just getting started. Now, in Never Grow Up, the global superstar reflects on his early life, including his childhood years at the China Drama Academy (in which he was enrolled at the age of six), his big breaks (and setbacks) in Hong Kong and Hollywood, his numerous brushes with death (both on and off film sets), and his life as a husband and father (which has been, admittedly and regrettably, imperfect). Jackie has never shied away from his mistakes. Since The Young Master in 1980, Jackie's films have ended with a bloopers reel in which he stumbles over his lines, misses his mark, or crashes to the ground in a stunt gone south. In Never Grow Up, Jackie applies the same spirit of openness to his life, proving time and time again why he's beloved the world over: he's honest, funny, kind, brave beyond reckoning and-after all this time-still young at heart.
BOOK
Double charge flips of polyamide membrane by ionic liquid-decoupled bulk and interfacial diffusion for on-demand nanofiltration
Fine design of surface charge properties of polyamide membranes is crucial for selective ionic and molecular sieving. Traditional membranes face limitations due to their inherent negative charge and limited charge modification range. Herein, we report a facile ionic liquid-decoupled bulk/interfacial diffusion strategy to elaborate the double charge flips of polyamide membranes, enabling on-demand transformation from inherently negative to highly positive and near-neutral charges. The key to these flips lies in the meticulous utilization of ionic liquid that decouples intertwined bulk/interfacial diffusion, enhancing interfacial while inhibiting bulk diffusion. These charge-tunable polyamide membranes can be customized for impressive separation performance, for example, profound Cl
−
/SO
4
2−
selectivity above 470 in sulfate recovery, ultrahigh Li
+
/Mg
2+
selectivity up to 68 in lithium extraction, and effective divalent ion removal in pharmaceutical purification, surpassing many reported polyamide nanofiltration membranes. This advancement adds a new dimension to in the design of advanced polymer membranes via interfacial polymerization.
Currently polyamide membranes fabricated by interfacial polymerization are limited by inherently negative charge as well as narrow charge tailoring window restricting the application of these membranes. Here, the authors report a facile ionic liquid-decoupled bulk/interfacial diffusion strategy to fabricate polyamide membranes which can transform on-demand from inherently negative to highly positive and near-neutral charge.
Journal Article
المدينة المحرمة في 600 عام = Forbidden city = Cheng
هي أكبر فضاء معماري موجود، وهي بحجمها واتساع رقعتها، تدل على هيمنة الإمبراطورية على العالم، وأيا كانت قوة ونفوذ المرء فإنه بمجرد دخوله المدينة المحرمة، يجد نفسه أشبه بحبة رمل في صحراء واسعة، لا أهمية له، وعليه أن يخضع لهيمنة ذلك الفضاء، وأن يخضع سيره وجلوسه لقوانين ذلك الفضاء ؛ أما بالنسبة للإمبراطور فالوضع مختلف، فهو وحده سيد المكان، فهو لا يخضع في ظهوره وفي أي مناسبة لأي قيد أو شرط، في جلوسه على عرش التنين في قاعة الانسجام الأسمى، يصبح مركز الكون، ولا سيطرة للفضاء الواسع عليه. عندما يفقد الناس ذواتهم في القصور الضخمة ففي ذلك استعارة لسلطة الإمبراطور على رعاياه المبنية على أساس معماري حينما يمر الإمبراطور في القصر يفرض هيمنته على الجميع.
Book
The Pursuit of Universality in Chinese Buddhism
Having adopted, appropriated, and altered Indian forms of Buddhism, various schools of Chinese Buddhist thought inherited and transformed essential orientations of both Buddhism and traditional Chinese philosophy insofar as it exhibits a tendency toward seeking universality in its understanding of the world. Within the works of prominent figures and schools such as Sengzhao and the Tiantai school, Huayan, the Consciousness-Only school, and Chan Buddhism, Chinese Buddhist thought integrates the diversity of phenomena through the notion of a unifying “mind-consciousness”. This approach creates the framework for understanding the relationship between humans and all things based on the comprehensive nature of consciousness. Given this foundation, Chinese Buddhist thought places a high value on the equality of all beings, advocates for dismantling distinctions between individuals and the world, and transcends the distinctions of reality to pursue universal unity. By dissolving the boundaries of existence and non-existence, the self and things, and the individual ego, this philosophical outlook lays a cognitive foundation for eradicating the “discriminating mind” in daily life and offers insights into overcoming separatism and isolationism. The Chinese Buddhist pursuit of universal consistency, which is simultaneously of this world yet transcendent, reflects Buddhism’s profound concern for humanity’s shared destiny.
Journal Article
The gale
\"One morning, so early that the fog still clings to the surface of the river, a young boy accompanies his yeye seven miles to the grassy field behind their home in order to cut satintail to feed the livestock.-- Provided by publisher.
Book
3-Nitropropionic Acid Induces Ovarian Oxidative Stress and Impairs Follicle in Mouse
Oxidative stress induces many serious reproductive diseases in female mammals and thus poses a serious threat to reproductive health. However, the relationship between reactive oxygen species (ROS)-induced oxidative stress and follicular development, oocyte and embryo quality is not clear. The aim of this study was to investigate the effect of ovarian oxidative stress on the health of follicle and oocyte development. Female ICR mice were dosed with 3-nitropropionic acid (3-NPA) at three different concentrations (6.25, 12.5 and 25 mg/kg) and saline (control) via continuous intraperitoneal injection for 7 days. The treatment with 12.5 mg/kg reduced the weight of mouse ovaries, and significantly increased ROS levels and the activities of antioxidant enzymes--total superoxide dismutase (T-SOD), glutathione peroxidase (GPx) and catalase (CAT)--in granulosa cells and ovarian tissues, but not in other tissues (brain, liver, kidney and spleen). The same treatment significantly increased the percentage of atretic large follicles, and reduced the number of large follicles, the number of ovulated oocytes, and the capacity for early embryonic development compared with controls. It also significantly decreased the ratio of Bcl-2 to Bax, while causing an increase in the mRNA expression of (SOD2, CAT and GP X) and ROS levels in granulosa cells. Collectively, these data indicate that 3-NPA induces granulosa cell apoptosis, large follicle atresia, and an increase of ROS levels in the ovary. Therefore, we have established an in vivo model of ovarian oxidative stress for studying the mechanism of resulting damage induced by free radicals and for the screening of novel antioxidants.
Journal Article