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While evolution (including human evolution), the safety and effectiveness of vaccines, global climate change, and cosmology featuring a universe that has billions of years of existence are all well established scientifically, many people don’t believe in them. [...]I can imagine guest appearances by Andre Geim, Konstantin Novoselov, Isamu Akasaki, Hiroshi Amano, Shuji Nakamura, F. Duncan M. Haldane, and J. Michael Kosterlitz, among Nobel Prize winners in Physics.5 I can also see them interacting with Nobel Prize winners in Chemistry such as Robert F. Curl Jr., Alan J. Heeger, Hideki Shirakawa, Gerhard Ertl, Dan Shechtman, Jean-Pierre Sauvage, Sir J. Fraser Stoddart, and Bernard L. Feringa.6 We could also co-opt Bill Nye, The Science Guy, for our program. TBBT also had an ongoing relationship with various characters from Star Trek, Star Wars, Battlestar Galactica, and Firefly.1 Following my theme of shameless imitation, we could have cameos by actors from the various Stargate franchises,7 as well as from Deep Space Nine8 and Star Trek: Voyager.9 TBBT also had ongoing references to Doctor Who,10 as well as characters from DC Comics11 and the Marvel Universe.12 Stan Lee, the creative brain behind the Marvel Universe, also had a cameo.13 Both the DC and Marvel universes have ongoing plot lines that involve exotic materials, whether involving various forms of kryptonite,14 the wonderful technologies used by Batman15 and the Flash,16 or the materials adamantium and vibranium, as well as the exotic materials in the infinity stones used by Iron Man, Captain America, Nick Fury, and others.12 Our characters would be fascinated by materials such as naquadah, naquadria, neutronium, and trinium from the Stargate franchises.17 I can visualize the interactions, discussions, and arguments among our characters about these fictitious materials.

How has your working relationship evolved over the years? STEVEN MOLARO With love, I'll say that season one of Big Bang was a challenging place to be. [...]Chuck, you know that at the end of season one, I had asked to leave. Fast-forward to Young Sheldon: What made you decide this was your next project to tackle? LORRE The beginning was a phone call from Jim Parsons, who sent me a video of his 10-year-old nephew in Texas who is a prodigy - brilliant, extraordinary, off the hook, crazy smart kid. LORRE The years when Steve was the showrunner on The Big Bang Theory, the thing I did was get out of the way. [...]it's been a learning curve ever since.