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"Puberty."
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Puberty in crisis : the sociology of early sexual development
\"Puberty has long been recognised as a difficult and upsetting process for individuals and families, but it is now also being widely described as in crisis. Reportedly occurring earlier and earlier as each decade of the twenty-first century passes, sexual development now heralds new forms of temporal trouble in which sexuality, sex/gender and reproduction are all at stake. Many believe that children are growing up too fast and becoming sexual too early. Clinicians, parents and teachers all demand something must be done. Does this out-of-time development indicate that children's futures are at risk or that we are entering a new era of environmental and social perturbation? Engaging with a diverse range of contemporary feminist and social theories on the body, biology and sex, Celia Roberts urges us to refuse a discourse of crisis and to rethink puberty as a combination of biological, psychological and social forces\"-- Provided by publisher.
Book
Correction to: “Serum Phoenixin Levels and Their Diagnostic Significance in Girls With Precocious Puberty”
[This corrects the article DOI: 10.1210/jendso/bvaf065.].
Journal Article
Coming of age around the world
Discover a wonderful world of celebrations from around the world. Featuring the world's main religions as well as some little-known ceremonies and festivals, this book takes an intriguing and colourful look at how growing up and coming of age are celebrated in many different places.
Book
The Beneficial Effect of Combined GH/GnRHa Therapy in Increasing Adult Height Outcome in Children With ISS
Abstract
Context
Management of GH-treated children with idiopathic short stature (ISS) with early puberty and adolescents in midpuberty at initiation of treatment is challenging.
Objective
To assess the effect of combined GH/GnRHa therapy during puberty on achieved adult height (AHt) in these children with ISS and to determine whether outcome depended on sex and pubertal status at initiation of GH therapy.
Design
Retrospective, single-center observational study from 2003-2018.
Setting
Tertiary endocrine center.
Patients
One hundred ninety-two GH-treated children with ISS; 58 of 192 were treated by GH/GnRHa during puberty; 31 of 58 were prepubertal (19 girls) and 27 of 58 pubertal (19 girls) at initiation of GH.
Main Outcome Measures
AHt, gain-in-height standard deviation score (SDS), AHt vs predicted adult height (PAHt), AHt vs target height (THt).
Results
Most boys and girls attained AHt SDS within the normal range (−0.73 ± 0.60 and −0.85 ± 0.65, respectively). Treatment modality, pubertal status, and sex were tested for their joint effect on growth outcome measures. Combined GH/GnRHa therapy increased AHt vs PAHt (P < 0.001) and AHt vs THt (P = 0.035). Prepubertal status at onset of GH treatment increased AHt (P = 0.049), gain-in-height SDS (P < 0.001), AHt vs PAHt (P < 0.001), and AHt vs THt (P = 0.042). Female sex increased AHt vs PAHt (P < 0.001).
Conclusions
Our study demonstrated a beneficial effect of combined GH/GnRHa therapy in increasing AHt outcome in children with ISS with early/normal puberty and in adolescents naïve to GH treatment who are in midpuberty at initiation of therapy. This effect was more pronounced in the prepubertal group and in girls. Prospective randomized controlled trials are needed to assess whether GnRHa can increase AHt in GH-treated children with ISS.
Combined GH/GnRHa therapy is beneficial in increasing AHt outcome in children with ISS with early/normal puberty and in adolescents naïve to GH treatment who are in midpuberty at start of therapy.
Journal Article
Changing you : a guide to body changes and sexuality
Puberty can be an exciting and confusing time for children. In her follow-up to \"Amazing You!,\" Dr. Saltz, with her renowned brand of warmth and candor, navigates curious youngsters through body changes for boys and girls, reproduction, and emerging sexuality.
Book
Clinical and Genetic Characterization of Familial Central Precocious Puberty
Abstract
Context
Central precocious puberty (CPP) can have a familial form in approximately one-quarter of the children. The recognition of this inherited condition increased after the identification of autosomal dominant CPP with paternal transmission caused by mutations in the MKRN3 and DLK1 genes.
Objective
We aimed to characterize the inheritance and estimate the prevalence of familial CPP in a large multiethnic cohort; to compare clinical and hormonal features, as well as treatment response to GnRH analogs (GnRHa), in children with distinct modes of transmission; and to investigate the genetic basis of familial CPP.
Methods
We retrospectively studied 586 children with a diagnosis of CPP. Patients with familial CPP (n = 276) were selected for clinical and genetic analysis. Data from previous studies were grouped, encompassing sequencing of MKRN3 and DLK1 genes in 204 patients. Large-scale parallel sequencing was performed in 48 individuals from 34 families.
Results
The prevalence of familial CPP was estimated at 22%, with a similar frequency of maternal and paternal transmission. Pedigree analyses of families with maternal transmission suggested an autosomal dominant inheritance. Clinical and hormonal features, as well as treatment response to GnRHa, were similar among patients with different forms of transmission of familial CPP. MKRN3 loss-of-function mutations were the most prevalent cause of familial CPP, followed by DLK1 loss-of-function mutations, affecting, respectively, 22% and 4% of the studied families; both affected exclusively families with paternal transmission. Rare variants of uncertain significance were identified in CPP families with maternal transmission.
Conclusion
We demonstrated a similar prevalence of familial CPP with maternal and paternal transmission. MKRN3 and DLK1 loss-of-function mutations were the major causes of familial CPP with paternal transmission.
Journal Article
Are you there God? It's me, Margaret.
Faced with the difficulties of growing up and choosing a religion, a twelve-year-old girl talks over her problems with her own private God.
Book
Delayed Puberty—Phenotypic Diversity, Molecular Genetic Mechanisms, and Recent Discoveries
This review presents a comprehensive discussion of the clinical condition of delayed puberty, a common presentation to the pediatric endocrinologist, which may present both diagnostic and prognostic challenges. Our understanding of the genetic control of pubertal timing has advanced thanks to active investigation in this field over the last two decades, but it remains in large part a fascinating and mysterious conundrum. The phenotype of delayed puberty is associated with adult health risks and common etiologies, and there is evidence for polygenic control of pubertal timing in the general population, sex-specificity, and epigenetic modulation. Moreover, much has been learned from comprehension of monogenic and digenic etiologies of pubertal delay and associated disorders and, in recent years, knowledge of oligogenic inheritance in conditions of GnRH deficiency. Recently there have been several novel discoveries in the field of self-limited delayed puberty, encompassing exciting developments linking this condition to both GnRH neuronal biology and metabolism and body mass. These data together highlight the fascinating heterogeneity of disorders underlying this phenotype and point to areas of future research where impactful developments can be made.
Journal Article