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Anti-pluralism : the populist threat to liberal democracy
The Great Recession, institutional dysfunction, a growing divide between urban and rural prospects, and failed efforts to effectively address immigration have paved the way for a populist backlash that disrupts the postwar bargain between political elites and citizens. Whether today's populism represents a corrective to unfair and obsolete policies or a threat to liberal democracy itself remains up for debate. Yet this much is clear: these challenges indict the triumphalism that accompanied liberal democratic consolidation after the collapse of the Soviet Union. To respond to today's crisis, good leaders must strive for inclusive economic growth while addressing fraught social and cultural issues, including demographic anxiety, with frank attention. Although reforms may stem the populist tide, liberal democratic life will always leave some citizens unsatisfied. This is a permanent source of vulnerability, but liberal democracy will endure so long as citizens believe it is worth fighting for.
Book
Anti-Pluralism
The Great Recession, institutional dysfunction, a growing divide between urban and rural prospects, and failed efforts to effectively address immigration have paved the way for a populist backlash that disrupts the postwar bargain between political elites and citizens. Whether today's populism represents a corrective to unfair and obsolete policies or a threat to liberal democracy itself remains up for debate. Yet this much is clear: these challenges indict the triumphalism that accompanied liberal democratic consolidation after the collapse of the Soviet Union. To respond to today's crisis, good leaders must strive for inclusive economic growth while addressing fraught social and cultural issues, including demographic anxiety, with frank attention. Although reforms may stem the populist tide, liberal democratic life will always leave some citizens unsatisfied. This is a permanent source of vulnerability, but liberal democracy will endure so long as citizens believe it is worth fighting for.
eBook
Trump must go : the top 100 reasons to dump Trump (and one to keep him)
\"Americans increasingly agree on one thing: Every day that Trump stays in office, he diminishes the United States and its people. In Trump Must Go, TV and radio host Bill Press offers 100 reasons why Trump needs to be removed from office, whether by impeachment, the 25th Amendment, or the ballot box. Beginning with the man himself and moving through Trump's executive action damage, Press covers Trump's debasement of the United States political system and degrading of the American presidency. Ranging from banning federal employees' use of the phrase 'climate change,' to putting down Haiti, El Salvador, and African nations as 'shithole' countries, we have to wonder what he'll do next. He has a bromance with Putin that enables several meetings between Trump staffers and Russian officials, and he has a wrecking crew administration: Attorney General Jeff Sessions, Education Secretary Betsy DeVos, and Housing Secretary Ben Carson, to name a few. Extensive 'executive time' marks Trump's calendar so he can golf, watch TV, and eat fast food. Trump has done it all...badly. But, in a political climate where the world has learned to expect the unexpected, Press offers readers a twist: one reason not to ditch Donald Trump.\"--Dust jacket.
Book
Inside Trump's White House : the real story of his presidency
\"In Inside Trump's White House, Doug Wead offers a history of President Donald J. Trump's first years in office, covering everything from election night to the news of today. The book includes never-before-reported stories. It also includes exclusive interviews with the Trump family about the Mueller report, and narrates their reactions when the report was finally released. Contains Interviews with the President in the Oval Office, chief of staff, Mick Mulvaney, Jared and Ivanka Kushner, Donald Trump, Jr., Eric and Lara Trump, and White House insiders\"-- adapted from book jacket.
Book
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59
cis
, 121
trans
). Integration of pQTL data with eQTL and disease genome-wide association studies provided insight into pathogenesis, implicating lymphotoxin-α in multiple sclerosis. Using Mendelian randomization (MR) to assess causality in disease etiology, we identified both shared and distinct effects of specific proteins across immune-mediated diseases, including directionally discordant effects of CD40 on risk of rheumatoid arthritis versus multiple sclerosis and inflammatory bowel disease. MR implicated CXCL5 in the etiology of ulcerative colitis (UC) and we show elevated gut
CXCL5
transcript expression in patients with UC. These results identify targets of existing drugs and provide a powerful resource to facilitate future drug target prioritization.
Here the authors identify genetic effectors of the level of inflammation-related plasma proteins and use Mendelian randomization to identify proteins that contribute to immune-mediated disease risk.
Journal Article
Siege : Trump under fire
In his follow-up to Fire and Fury, Michael Wolff writes about a presidency under fire from almost every side. At the outset of Trump's second year as president, his situation is profoundly different. No longer tempered by experienced advisers, he is more impulsive and volatile than ever. But the wheels of justice are inexorably turning: Robert Mueller's 'witch hunt' haunts Trump every day, and other federal prosecutors are taking a deep dive into his business affairs. Many in the political establishment -- even some members of his own administration -- have turned on him and are dedicated to bringing him down. The Democrats see victory at the polls, and perhaps impeachment, in front of them. Trump, meanwhile, is certain he is invincible, making him all the more exposed and vulnerable. Week by week, as Trump becomes increasingly erratic, the question that lies at the heart of his tenure becomes ever more urgent : Will this most abnormal of presidencies at last reach the breaking point and implode?
Book
Methods for mapping 3D chromosome architecture
Determining how chromosomes are positioned and folded within the nucleus is critical to understanding the role of chromatin topology in gene regulation. Several methods are available for studying chromosome architecture, each with different strengths and limitations. Established imaging approaches and proximity ligation-based chromosome conformation capture (3C) techniques (such as DNA-FISH and Hi-C, respectively) have revealed the existence of chromosome territories, functional nuclear landmarks (such as splicing speckles and the nuclear lamina) and topologically associating domains. Improvements to these methods and the recent development of ligation-free approaches, including GAM, SPRITE and ChIA-Drop, are now helping to uncover new aspects of 3D genome topology that confirm the nucleus to be a complex, highly organized organelle.How chromosomes are positioned and folded within the nucleus has implications for gene regulation. In this Review, Kempfer and Pombo describe and evaluate methods for studying chromosome architecture and outline the insights they are providing about nuclear organization.
Journal Article
The Daily Show with Trevor Noah presents The Donald J. Trump Presidential Twitter Library
June, 2017. Comprised of hundreds of actual Trump tweets, the staff of The Daily Show opened The Donald J. Trump Presidential Twitter Library, a 4,000-square-foot museum space dedicated to the 45th president and his Twitter legacy. In the single weekend it was open to the public, the Library pop-up drew 7,500 visitors. Now the entire country can experience the Presidential Twitter Library, with screenshots of the tweets (from 2009 through 2017), accompanied by analysis and commentary.
BOOK
Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies
Transcriptome profiling is widely used to infer functional states of specific cell types, as well as their responses to stimuli, to define contributions to physiology and pathophysiology. Focusing on microglia, the brain’s macrophages, we report here a side-by-side comparison of classical cell-sorting-based transcriptome sequencing and the ‘RiboTag’ method, which avoids cell retrieval from tissue context and yields translatome sequencing information. Conventional whole-cell microglial transcriptomes were found to be significantly tainted by artifacts introduced by tissue dissociation, cargo contamination and transcripts sequestered from ribosomes. Conversely, our data highlight the added value of RiboTag profiling for assessing the lineage accuracy of Cre recombinase expression in transgenic mice. Collectively, this study indicates method-based biases, reveals observer effects and establishes RiboTag-based translatome profiling as a valuable complement to standard sorting-based profiling strategies.
Isolating tissue-resident cells runs the risk of altering their expression profile. Jung and colleagues use a RiboTagging approach to describe the microglial translatome and demonstrate that macrophage extraction from their tissue environment results in significant transcriptional alterations.
Journal Article