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The cigarette is the deadliest artifact in the history of human civilization. It is also one of the most beguiling, thanks to more than a century of manipulation at the hands of tobacco industry chemists. In Golden Holocaust, Robert N. Proctor draws on reams of formerly-secret industry documents to explore how the cigarette came to be the most widely-used drug on the planet, with six trillion sticks sold per year. He paints a harrowing picture of tobacco manufacturers conspiring to block the recognition of tobacco-cancer hazards, even as they ensnare legions of scientists and politicians in a web of denial. Proctor tells heretofore untold stories of fraud and subterfuge, and he makes the strongest case to date for a simple yet ambitious remedy: a ban on the manufacture and sale of cigarettes.

Quantification of the disease burden caused by different risks informs prevention by providing an account of health loss different to that provided by a disease-by-disease analysis. No complete revision of global disease burden caused by risk factors has been done since a comparative risk assessment in 2000, and no previous analysis has assessed changes in burden attributable to risk factors over time. We estimated deaths and disability-adjusted life years (DALYs; sum of years lived with disability [YLD] and years of life lost [YLL]) attributable to the independent effects of 67 risk factors and clusters of risk factors for 21 regions in 1990 and 2010. We estimated exposure distributions for each year, region, sex, and age group, and relative risks per unit of exposure by systematically reviewing and synthesising published and unpublished data. We used these estimates, together with estimates of cause-specific deaths and DALYs from the Global Burden of Disease Study 2010, to calculate the burden attributable to each risk factor exposure compared with the theoretical-minimum-risk exposure. We incorporated uncertainty in disease burden, relative risks, and exposures into our estimates of attributable burden. In 2010, the three leading risk factors for global disease burden were high blood pressure (7·0% [95% uncertainty interval 6·2–7·7] of global DALYs), tobacco smoking including second-hand smoke (6·3% [5·5–7·0]), and household air pollution from solid fuels (4·3% [3·4–5·3]). In 1990, the leading risks were childhood underweight (7·9% [6·8–9·4]), household air pollution from solid fuels (HAP; 6·8% [5·5–8·0]), and tobacco smoking including second-hand smoke (6·1% [5·4–6·8]). Dietary risk factors and physical inactivity collectively accounted for 10·0% (95% UI 9·2–10·8) of global DALYs in 2010, with the most prominent dietary risks being diets low in fruits and those high in sodium. Several risks that primarily affect childhood communicable diseases, including unimproved water and sanitation and childhood micronutrient deficiencies, fell in rank between 1990 and 2010, with unimproved water and sanitation accounting for 0·9% (0·4–1·6) of global DALYs in 2010. However, in most of sub-Saharan Africa childhood underweight, HAP, and non-exclusive and discontinued breastfeeding were the leading risks in 2010, while HAP was the leading risk in south Asia. The leading risk factor in Eastern Europe, Andean Latin America, and southern sub-Saharan Africa in 2010 was alcohol use; in most of Asia, most of Latin America, North Africa and Middle East, and central Europe it was high blood pressure. Despite declines, tobacco smoking including second-hand smoke remained the leading risk in high-income north America and western Europe. High body-mass index has increased globally and it is the leading risk in Australasia and southern Latin America, and also ranks high in other high-income regions, North Africa and Middle East, and Oceania. Worldwide, the contribution of different risk factors to disease burden has changed substantially, with a shift away from risks for communicable diseases in children towards those for non-communicable diseases in adults. These changes are related to the ageing population, decreased mortality among children younger than 5 years, changes in cause-of-death composition, and changes in risk factor exposures. New evidence has led to changes in the magnitude of key risks including unimproved water and sanitation, vitamin A and zinc deficiencies, and ambient particulate matter pollution. The extent to which the epidemiological shift has occurred and what the leading risks currently are varies greatly across regions. In much of sub-Saharan Africa, the leading risks are still those associated with poverty and those that affect children. Bill & Melinda Gates Foundation.

Through the rise and fall of empires, ideologies, and economies, tobacco grown on the tiny island of Cuba has remained an enduring symbol of pleasure and extravagance. Cultivated as one of the first reliable commodities for those inhabitants who remained after conquistadors moved on in search of a mythical wellspring of gold, tobacco quickly became crucial to the support of the swelling Spanish Empire in the seventeenth and eighteenth centuries. Eventually, however, tobacco became one of the final stabilizing forces in the empire, and it ultimately proved more resilient than the best laid plans of kings and queens. Tobacco, and those whose livelihoods depended on it, shrugged off the Empire's collapse and pressed on into the twentieth century as an economic force any state or political power must reckon with. Cosner explores the history of this golden leaf through the personal narratives of farmers, bureaucrats, and laborers, all struggling to build an independent and lucrative economic engine. Through conquest, rebellion, colonial and imperial schemes, and the eventual Communist revolution, Cuban tobacco and cigars became a luxury item that commanded loyalty that defied mere borders or embargoes. Ultimately, The Golden Leaf is a story of two carefully cultivated products: Cuban tobacco, and its lofty reputation.

The tobacco cutworm, Spodoptera litura , is among the most widespread and destructive agricultural pests, feeding on over 100 crops throughout tropical and subtropical Asia. By genome sequencing, physical mapping and transcriptome analysis, we found that the gene families encoding receptors for bitter or toxic substances and detoxification enzymes, such as cytochrome P450, carboxylesterase and glutathione- S -transferase, were massively expanded in this polyphagous species, enabling its extraordinary ability to detect and detoxify many plant secondary compounds. Larval exposure to insecticidal toxins induced expression of detoxification genes, and knockdown of representative genes using short interfering RNA (siRNA) reduced larval survival, consistent with their contribution to the insect’s natural pesticide tolerance. A population genetics study indicated that this species expanded throughout southeast Asia by migrating along a South India–South China–Japan axis, adapting to wide-ranging ecological conditions with diverse host plants and insecticides, surviving and adapting with the aid of its expanded detoxification systems. The findings of this study will enable the development of new pest management strategies for the control of major agricultural pests such as S .  litura . Genome of the tobacco cutworm, Spodoptera litura , which is one of the most widespread and destructive agricultural pests in tropical and subtropical Asia.

Today we know the risks of smoking tobacco, but over 100 years ago the dangers were less well known, and tobacco became a booming business in Kentucky. Its success can impart be credited to the Burley tobacco press.

The 1998 out-of-court settlements of litigation by the states against the cigarette industry totaled 243 billion, making it the largest payoff ever in our civil justice system. Two key questions drove the lawsuits and the attendant settlement: Do smokers understand the risks of smoking? And does smoking impose net financial costs on the states? With Smoke-Filled Rooms,W. Kip Viscusi provides unexpected answers to these questions, drawing on an impressive range of data on several topics central to the smoking policy debate. Based on surveys of smokers in the United States and Spain, for instance, he demonstrates that smokers actually overestimate the dangers of smoking, indicating that they are well aware of the risks involved in their choice to smoke. And while smoking does increase medical costs to the states, Viscusi finds that these costs are more than financially balanced by the premature mortality of smokers, which reduces their demands on state pension and health programs, so that, on average, smoking either pays for itself or generates revenues for the states. Viscusi's eye-opening assessment of the tobacco lawsuits also includes policy recommendations that could frame these debates in a more productive way, such as his suggestion that the FDA should develop a rating system for cigarettes and other tobacco products based on their relative safety, thus providing an incentive for tobacco manufacturers to compete among themselves to produce safer cigarettes. Viscusi's hard look at the facts of smoking and its costs runs against conventional thinking. But it is also necessary for an informed and realistic debate about the legal, financial, and social consequences of the tobacco lawsuits. People making 50,000 or more pay .08 percent of their income in cigarette taxes, but people with incomes of less than 10,000 pay 1.62 percenttwenty times as

Malawi, the world's most tobacco-dependent country, has long defended the tobacco industry as essential to its economy. The impoverished living conditions of tobacco farmers, however, raise questions about the true benefits accruing to the country. While the government and industry often blame public health advocates for declining leaf prices, and thus lower returns to farmers, this article scrutinises these claims from a historical perspective. It argues that a context of state capture has characterised Malawi's tobacco industry, originating with colonisation and evolving since to become increasingly entrenched. The analysis is divided into four periods: colonial (1890s-1964); national (1964-1981); liberalisation (1981-2004) and accelerated globalisation (2004 to present). Each period demonstrates how industry interests influenced government institutions and policies in ways that increased dependence on a crop that only benefits a minority of Malawians. Today, a transnational elite prospers at the expense of local growers.

You may have heard of first and second-hand smoke but did you know about third hand and after smoke? NIST scientists have measured how much chemical airborne emissions we are exposed to once a cigarette but has been extinguished.

Description of the subject. In Turkey Basma tobaccos have been produced as landraces. However, little is known about the genetic and agronomic diversity of the Basma tobacco landrace. Objectives. The aim of the present study was to determine the genetic variation level in Basma type tobaccos used in Tokat- Erbaa region of Turkey, to evaluate some lines under field conditions for agronomic variations and to find out lines with superior yield and quality characters. Method. Thirteen simple sequence repeats (SSR) markers were used to determine the genetic diversity among 40 single plants collected from Basma tobacco production areas along with the cultivar Xanthi-2A. Twenty-seven different lines identified by SSR markers and cultivar Xanthi-2A were evaluated under field conditions in three Basma tobacco production areas. Results. All SSR markers were polymorphic and PIC values of the markers ranged from 0.136 to 0.679 with a total of 43 alleles. There were high levels of variation in agronomic characters investigated. The results of the field evaluations showed that most lines had good agronomic characters and some of them were considerably better in quality than Xanthi-2A. In principal component analysis performed with agronomic characters, the first three components explained 85.4% of the total variation. Conclusions. We determined that the lines 5, 7, 16, 19, 21 and 26 were promising cultivar candidates with good performance. These lines could be further examined for the aim of registration or could be used for development of superior cultivars.