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It's fall
\"When the leaves start falling and days get colder, Fall is officially here. In this engaging fiction title, a relatable narrator and their friends and family show readers everything that makes Fall unique.\" -- Amazon.com.
Book
P201 Twice-yearly depemokimab efficacy is sustained across seasons in patients with asthma: analyses of pooled phase III SWIFT-1/2 studies
Introduction and ObjectivesDepemokimab is the first ultra-long-acting biologic with enhanced interleukin-5 binding affinity, high potency and extended half-life, enabling twice-yearly dosing in patients with asthma. In the Phase III SWIFT-1/2 studies, depemokimab significantly reduced exacerbations with sustained inhibition of type 2 inflammation assessed by blood eosinophil count (BEC) observed in patients with type 2 asthma. Seasonal changes in common triggers for asthma exacerbations, including respiratory viruses, are well described; as such, this analysis of data from the SWIFT-1/2 studies aimed to explore whether depemokimab efficacy in reducing exacerbations versus placebo is sustained across all seasons.MethodIn SWIFT-1/2, patients with asthma who had ≥2 exacerbations in the past year and BEC ≥150 cells/µL (screening) or ≥300 cells/µL (past year) were randomised 2:1 to receive depemokimab 100 mg subcutaneously or placebo once every 26 weeks, plus standard of care. Analyses of pooled data from the SWIFT-1/2 studies were conducted to investigate annualised exacerbation rates (total number of exacerbations divided by total number of subject-years) by season (spring/summer/autumn/winter).ResultsOf 762 patients included in the SWIFT-1/2 studies, 260 received placebo and 502 received depemokimab. Depemokimab was associated with reduced exacerbation rates versus placebo across all four seasons; the greatest benefit observed in spring, autumn and winter, with a 58% reduction in exacerbations in spring (rate ratio: 0.42 [95% confidence interval CI: 0.29, 0.61]), a 40% reduction in summer (0.60 [0.40, 0.90]), a 55% reduction in autumn (0.45 [0.32, 0.63]) and a 56% reduction in winter (0.44 [0.32, 0.60]) (figure 1). The annualised exacerbation rates (95% CI) in the depemokimab arm remained broadly consistent across all four seasons (spring: 0.46 [0.35, 0.61]; summer: 0.47 [0.36, 0.62]; autumn: 0.56 [0.44, 0.71]; winter: 0.57 [0.45, 0.72]; however, in the placebo arm exacerbation rates were, as expected, numerically lower in summer (spring: 1.10 [0.84, 1.43]; summer: 0.78 [0.58, 1.07]; autumn: 1.23 [0.97, 1.56]; winter: 1.30 [1.03, 1.63]) (figure 1).Abstract P201 Figure 1Annualised exacerbation rate reductions in patients receiving depemokimab versus placebo were consistent across spring, autumn and winter, with a lower magnitude of reduction in summer due to reduced exacerbation rates in the placebo group[Image Omitted. See PDF.]ConclusionOverall, twice-yearly depemokimab demonstrated a sustained clinical benefit for patients with type 2 asthma across all four seasons, regardless of additional exacerbation triggers over the autumn and winter months.
Journal Article
What happens in fall?
\"Readers learn the basic science of fall and understand why the weather gets colder as the year goes on\"-- Publisher's website.
Book
Jesenski utrip 2025
All key stakeholders in surveying participated in the meeting (representatives of the Surveying and Mapping Authority; the Faculty of Civic and Geodetic Engineering; the Economic Interest Group of Surveyors; the Slovenian Chamber of Engineers; the Geodetic Institute of Slovenia; and the Society of Court Experts and Certified Appraisers in Surveying). Innovative networking concepts have become a constant in both social and professional events organised by societies. [...]the foreseeable future may well bring a welcome change making people step away from modern technology with its alienation effects. The Association working group responsible for the development of surveying strategy met for the third time in 2025.
Journal Article
Fall
Simple text and photographs describe fall, discussing the weather, crops, trees, animals, festivals, and more.
Book
Dinosaurs in the fall
When the weather starts to get colder, dinosaurs find new ways to have fun. In this innovative first concepts book, dinosaurs dive into autumn in a variety of ways. Readers will see dinos take walks, watch leaves fall, and pick apples off of trees with the help of colorful illustrations that add picture-text correlation to an engaging look at the changing seasons. With text designed to establish a foundation for future reading success, this book is sure to be a hit with readers year-round. Age Appropriate and Achievable Content, Illustrated, Picture Glossary.
Book
Search for Pentaquark Theta super(+) in Hadronic Reaction at J-PARC
The first experiment at the J-PARC hadron facility, the J-PARC E19 experiment, aims at searching for the Theta super(+) pentaquark in the hadronic reaction pi super(-) p arrow right K super(-) X using the missing-mass technique. Based on a superconducting magnet excited at 2.5 T, the spectrometer achieved the high mass resolution of 1.4 MeV/c super(2) for the Theta super(+) production process. The first data taking was performed in the autumn of 2010. No significant structure was observed in the missing-mass spectrum. The upper limit obtained for the differential cross section is 0.26 mu b/sr in the laboratory frame at a 90 % CL.
Journal Article
Divergent Impacts of Precipitation Regimes on Autumn Phenology in the Northern Hemisphere Mid‐ to High‐Latitudes
Climate change has altered precipitation regimes and shifted the end of the vegetation growing season (end of the season [EOS]), with consequences for terrestrial carbon and water cycles. However, the impacts of precipitation regimes, that is, total precipitation (Ptotal) and precipitation frequency (Pfreq), on EOS remain unclear. Using satellite‐derived phenology data from 1982 to 2020, we examined the effects of precipitation regimes on EOS across the mid‐ to high‐latitudes of the Northern Hemisphere. We found that both increased Ptotal and decreased Pfreq delayed EOS, with the effect of reduced Pfreq likely mediated through increased maximum temperature and elevated soil moisture resulting from higher precipitation intensity. We further developed a process‐based autumn phenology model that incorporated the effect of Pfreq, which significantly improved model performance. These findings underscore the influence of precipitation regimes on EOS and highlight the need to account for both precipitation frequency and intensity when projecting vegetation carbon uptake under future climate scenarios.
Journal Article