Explore the vast range of titles available.

Shared decision-making (SDM) has been practiced fairly frequently in general medicine, but less so in mental disorders, especially in closed psychiatric wards, and its positive predictor has recently been recognized in the field of mental health. Studies have shown that patients with severe mental disorders want a say in their care and their desire to participate in clinical decision-making is even higher than those treated by general medical services. This review aims to explore the research progress of SDM for patients with schizophrenia with anxiety in a collectivist culture (such as Chinese culture) and to provide a reference for the implementation of SDM in closed psychiatric wards.

Chronic nasal mucosal inflammatory disease is a common nasal disease, which is involved by inflammatory cells and a variety of cytokines. Its main pathological features are inflammatory reaction, increased secretion, mucosal swelling and thickening of nasal cavity or paranasal sinuses.It mainly includes chronic rhinitis (divided into allergic rhinitis, non-allergic rhinitis), chronic sinusitis (divided into with nasal polyps, without nasal polyps type), etc.The main symptoms of chronic rhinitis are nasal itching, sneezing, runny nose, and nasal congestion. The main symptoms of chronic sinusitis are nasal congestion, purulent or sticky nasal discharge, headache, and reduced sense of smell. They are a type of disease with a high incidence rate and seriously affect the quality of human life.Although the etiology and treatment of this type of disease have been extensively studied, there are still many aspects that are unclear.Currently, oxidative stress is believed to be an important link in the pathogenesis of chronic inflammatory diseases of the nasal mucosa. Therefore, anti-oxidative stress is a direction of research for the treatment of chronic nasal mucosal inflammatory diseases.Hydrogen, as a medically therapeutic gas, has been extensively studied for its antioxidant, anti-inflammatory, and anti-damage properties, and has been used in the treatment of various diseases.Although there are relatively few studies on the use of hydrogen for nasal inflammation, its positive effects have also been found. This article systematically summarizes the relevant research on the use of hydrogen to improve chronic nasal mucosal inflammation, with the aim of clarifying the ideas and indicating the direction for further research in the future.

Animal and clinical studies have confirmed the therapeutic effect of bone marrow mesenchymal stem cells on cerebral ischemia, but their mechanisms of action remain poorly understood. Here, we summarize the transplantation approaches, directional migration, differentiation, replacement, neural circuit reconstruction,angiogenesis, neurotrophic factor secretion, apoptosis, immunomodulation, multiple mechanisms of action,and optimization strategies for bone marrow mesenchymal stem cells in the treatment of ischemic stroke.We also explore the safety of bone marrow mesenchymal stem cell transplantation and conclude that bone marrow mesenchymal stem cell transplantation is an important direction for future treatment of cerebral ischemia. Determining the optimal timing and dose for the transplantation are important directions for future research.

Objective: The aim of this study was to help people comprehensively understand the research advances related to ring finger protein 213 (RNF213) in moyamoya disease (MMD) and to understand the disease at the molecular level to provide a new perspective of the diagnosis of the disease. Data Sources: This review was based on data in articles published between 2005 and 2015 that were retrieved from the PubMed database. The search terms included RNF213, MMD, intracranial major artery stenosis /occlusion (ICASO), genotype, phenotype, mutant and variants, and the combinations of these terms. Study Selection: Articles related to MMD and RNF213 were selected for review, and we also reviewed publications related to ICASO. Results: RNF213 is not only associated with MMD but also associated with intracranial major artery stenosis. In addition, RNF213 variants exhibit apparent ethnic diversity; specifically, the c.14576G>A variant is mainly detected in Korean, Chinese, and Japanese populations, particularly the latter population. The genotypes of RNF213 correlate with the phenotypes of MMD; for example, the homozygous c.14576G>A variant is associated with early-onset, severe symptoms, and an unfavorable prognosis. Furthermore, the RNF213 c.14576G>A variant should be considered during the diagnosis of MMD because no patients with quasi-MMD have been reported to carry the RNF213 c.14576G>A variant whereas 66 of 78 patients with definite MMD have been found to carry this variant. Conclusions: The growing literature demonstrates that MMD is primarily caused by the synergy of genetic and environmental factors, and unknown genetic modifiers might play roles in the etiology of MMD. Further research should be conducted to clarify the pathogenic mechanism of MMD.

A growing number of publications have shown that resveratrol has anticancer effects and has become a hotspot in cancer research. The purpose of this study is to analyze the academic results and research trends in resveratrol within the field of anticancer and to predict the future trends in this field. We conducted a literature search for resveratrol in anticancer research from 2003 to 2022 using the Science Citation Index Expanded of the Web of Science Core Collection. The visualization software was used to perform the bibliometric analysis. A total of 1463 publications from 2003 to 2022 were retrieved. China had the highest number of publications. Taipei Medical University became the research institution with the largest number of publications worldwide. The journals with the highest output and co‐citation frequency were Molecules and Cancer Research. Levenson, Anait S and Jaeger, Walter published the largest number of papers. Jang, MS was the most co‐cited author. Timeline View shows trends and relationship between research topics over time and suggests that the emerging frontier of resveratrol in anticancer may be “resveratrol induces apoptosis.” As more and more evidence shows the important role of resveratrol in anticancer, further research on its mechanisms and target discovery may become a major direction for future research. The bibliometric analysis findings of this study will significantly contribute to scholars' comprehensive understanding of the anticancer effects and mechanisms of action of resveratrol, aiding in delineating research hotspots and frontier directions within this field, thereby providing guidance for future investigations. Resveratrol exerts its antitumor effects through multiple mechanisms and has great potential as an anticancer agent for the prevention and treatment of many types of cancer. The bibliometric analysis findings of this study will significantly contribute to scholars' comprehensive understanding of the anticancer effects and mechanisms of action of resveratrol, aiding in delineating research hotspots and frontier directions within this field, thereby providing guidance for future investigations.

As one of the largest Phanerozoic orogens in the world, the Central Asian Orogenic Belt (CAOB) is a natural laboratory for studies of continental dynamics and metallogenesis. This paper summarizes the research progresses of the accretionary processes and metallogenesis of the CAOB since the People’s Republic of China was founded, and puts forward the prospect for future research. During the early period (1950s–1970s), several geological theories were applied to explain the geological evolution of Central Asia. In the early period of China’s reform and opening-up, the plate tectonics theory was applied to explain the evolution of the northern Xinjiang and Xingmeng regions, and the opinion of subduction-collision between Siberian, Kazakhstan, and China-North Korea-Tarim plates was proposed. The idea of the Solonker-Yanbian suture zone was established. In the 1990s, the study of the CAOB entered a period of rapid development. One school of scholars including geologists from the former Soviet Union proposed a multi-block collision model for the assemblage of the CAOB. In contrast, another school of scholars, led by a Turkish geologist, Celal Şengör, proposed that the Altaids was formed through the growth and strike-slip duplicates of a single island arc, and pointed out that the Altaids is a special type of collisional orogen. During this period, Chinese geologists carried out a lot of pioneering researches on ophiolites and high-pressure metamorphic rocks in northern China, and confirmed the main suture zones accordingly. In 1999, the concept of “Central Asian metallogenic domain” was proposed, and it became one of the three major metallogenic domains in the world. Since the 21st century, given the importance for understanding continental accretion and metallogenic mechanism, the CAOB has become the international academic forefront. China has laid out a series of scientific research projects in Central Asia. A large number of important scientific research achievements have been spawned, including the tectonic attribution of micro-continents, timing and tectonic settings of ophiolites, magmatic arcs, identification and anatomy of accretionary wedges, regional metamorphism-deformation, (ultra)high-pressure metamorphism, ridge subduction, plume-plate interaction, archipelagic paleogeography and spatio-temporal framework of multiple accretionary orogeny, continental growth, accretionary metallogenesis, structural superposition and transformation, etc. These achievements have made important international influences. There still exist the following aspects that need further study: (1) Early evolution history and subduction initiation of the Paleo-Asian Ocean; (2) The accretionary mechanism of the extroversion Paleo-Asian Ocean; (3) The properties of the mantle of the Paleo-Asian Ocean and their spatiotemporal distribution; (4) The interaction between the Paleo-Asian Ocean and the Tethys Ocean; (5) Phanerozoic continental growth mechanism and its global comparison; (6) Accretionary metallogenic mechanism of the Central Asian metallogenic domain; and (7) Continental transformation mechanism.

The unique anatomical and physiological connections between the nasal cavity and brain provide a pathway for bypassing the blood–brain barrier to allow for direct brain-targeted drug delivery through nasal administration. There are several advantages of nasal administration compared with other routes; for example, the first-pass effect that leads to the metabolism of orally administered drugs can be bypassed, and the poor compliance associated with injections can be minimized. Nasal administration can also help maximize brain-targeted drug delivery, allowing for high pharmacological activity at lower drug dosages, thereby minimizing the likelihood of adverse effects and providing a highly promising drug delivery pathway for the treatment of central nervous system diseases. The aim of this review article was to briefly describe the physiological structures of the nasal cavity and brain, the pathways through which drugs can enter the brain through the nose, the factors affecting brain-targeted nasal drug delivery, methods to improve brain-targeted nasal drug delivery systems through the application of related biomaterials, common experimental methods used in intranasal drug delivery research, and the current limitations of such approaches, providing a solid foundation for further in-depth research on intranasal brain-targeted drug delivery systems (see Graphical Abstract ).

Fluorine is one of the trace elements necessary for health. It has many physiological functions, and participates in normal metabolism. However, fluorine has paradoxical effects on the body. Many studies have shown that tissues and organs of humans and animals appear to suffer different degrees of damage after long‐term direct or indirect exposure to more fluoride than required to meet the physiological demand. Although the aetiology of endemic fluorosis is clear, its specific pathogenesis is inconclusive. In the past 5 years, many researchers have conducted in‐depth studies into the pathogenesis of endemic fluorosis. Research in the areas of fluoride‐induced stress pathways, signalling pathways and apoptosis has provided further extensive knowledge at the molecular and genetic level. In this article, we summarize the main results.

With the development of remote monitoring technology and highly integrated circuit technology, the achievement and usage of self-powered wireless low-power electronic components has become a hot research topic nowadays. Harvesting vibration energy from the environment can meet the power consumption requirements of these devices, while it is also of great significance to fully utilize the hidden energy in the environment. The mechanism and three typical working modes of piezoelectric vibration energy harvesting technology are introduced, along with the classification of different excitation types of collectors. The progress of research related to piezoelectric vibration energy harvesting technology is reviewed. Finally, challenging problems in the study of piezoelectric energy harvesting technology are summarized, and the future research and development trend of piezoelectric vibration energy harvesting technology is discussed in the light of the current research status of piezoelectric vibration energy harvesting technology.

Crowdsourcing is one of the emerging Web 2.0 based phenomenon and has attracted great attention from both practitioners and scholars over the years. It can facilitate the connectivity and collaboration of people, organizations, and societies. We believe that Information Systems scholars are in a unique position to make significant contributions to this emerging research area and consider it as a new research frontier. However, so far, few studies have elaborated what have been achieved and what should be done. This paper seeks to present a critical examination of the substrate of crowdsourcing research by surveying the landscape of existing studies, including theoretical foundations, research methods, and research foci, and identifies several important research directions for IS scholars from three perspectives—the participant, organization, and system—and which warrant further study. This research contributes to the IS literature and provides insights for researchers, designers, policy-makers, and managers to better understand various issues in crowdsourcing systems and projects.