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Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults
In a placebo-controlled, phase 2–3 trial, one dose of mRNA-1345 led to a lower incidence of RSV disease among adults 60 years of age or older. Solicited local and systemic adverse reactions occurred more often with the vaccine.
Journal Article
COVID-19 : the pandemic that never should have happened, and how to stop the next one
Over the last 30 years, we learned every lesson needed to stop this coronavirus outbreak in its tracks. We heeded almost none of them. The result is a pandemic on a scale never before seen in our lifetimes. Here, science journalist Debora MacKenzie lays out the full story of how and why it happened: the previous viruses that should have prepared us, the shocking public health failures that paved the way, the failure to contain the outbreak, and most importantly, what we must do to stop this happening again. Offering a compelling history of the most significant recent outbreaks, including SARS, MERS, H1N1, Zika, and Ebola, MacKenzie outlines the lessons we failed to learn from each past crisis. But looking forward, she makes a bold, optimistic argument : this pandemic might finally galvanize the world to take viruses seriously. No one has yet brought together our knowledge of Covid-19 in a comprehensive, informative, and accessible way. But that story can already be told, and Debora MacKenzie's urgent telling is required reading for these times and beyond. Fighting this pandemic and preventing the next one will take political action of all kinds, globally, from governments, the scientific community, and individuals -- and if we act now, it is possible.
Book
An evaluation of the economic effects of bovine respiratory disease on animal performance, carcass traits, and economic outcomes in feedlot cattle defined using four BRD diagnosis methods
Abstract
Bovine respiratory disease (BRD) causes significant economic losses to the feedlot industry due to decreased production and increased costs associated with treatment. This study aimed to assess the impacts of BRD on performance, carcass traits, and economic outcomes defined using four BRD diagnosis methods: number of BRD treatments an animal received, pleural lesions at slaughter, lung lesions at slaughter, and clinical BRD status defined using both treatment records and lung and pleural lesions. Crossbred steers (n = 898), with an initial body weight of 432 kg (± SD 51), were followed from feedlot entry to slaughter. Veterinary treatment records were collected and lungs scored at slaughter for lesions indicative of BRD. There was an 18% morbidity rate and a 2.1% BRD mortality rate, with an average net loss of AUD$1,647.53 per BRD mortality. Animals treated ≥3 times for BRD had 39.6 kg lighter carcasses at slaughter and returned an average of AUD$384.97 less compared to animals never treated for BRD (P < 0.001). Animals with severe lung lesions at slaughter grew 0.3 kg/d less, had 14.3 kg lighter carcasses at slaughter, and returned AUD$91.50 less than animals with no lung lesions (P < 0.001). Animals with subclinical and clinical BRD had 16.0 kg and 24.1 kg lighter carcasses, respectively, and returned AUD$67.10 and AUD$213.90 less at slaughter, respectively, compared to healthy animals that were never treated with no lesions (P < 0.001). The severity of BRD based on the number of treatments an animal received and the severity of lung and pleural lesions reduced animal performance, carcass weight and quality, and economic returns. Subclinical BRD reduced animal performance and economic returns compared to healthy animals; however, subclinical animals still had greater performance than animals with clinical BRD. This information can be used to plan for strategic investments aimed at reducing the impacts of BRD in feedlot cattle such as improved detection methods for subclinical animals with lesions at slaughter and BRD treatment protocols.
Journal Article
Improving lung health in low-income and middle-income countries: from challenges to solutions
Low-income and middle-income countries (LMICs) bear a disproportionately high burden of the global morbidity and mortality caused by chronic respiratory diseases (CRDs), including asthma, chronic obstructive pulmonary disease, bronchiectasis, and post-tuberculosis lung disease. CRDs are strongly associated with poverty, infectious diseases, and other non-communicable diseases (NCDs), and contribute to complex multi-morbidity, with major consequences for the lives and livelihoods of those affected. The relevance of CRDs to health and socioeconomic wellbeing is expected to increase in the decades ahead, as life expectancies rise and the competing risks of early childhood mortality and infectious diseases plateau. As such, the World Health Organization has identified the prevention and control of NCDs as an urgent development issue and essential to the achievement of the Sustainable Development Goals by 2030. In this Review, we focus on CRDs in LMICs. We discuss the early life origins of CRDs; challenges in their prevention, diagnosis, and management in LMICs; and pathways to solutions to achieve true universal health coverage.
Journal Article
The case of the sneezy popcorn : Annie Biotica solves respiratory system disease crimes
\"Learn about strep throat, Hantavirus, whooping cough, Pneumonia, and the differences between the cold and the flu. Then try to guess the disease in three different cases\"-- Provided by publisher.
BOOK
Understanding the mechanisms of viral and bacterial coinfections in bovine respiratory disease: a comprehensive literature review of experimental evidence
Bovine respiratory disease (BRD) is one of the most important diseases impacting the global cattle industry, resulting in significant economic loss. Commonly referred to as shipping fever, BRD is especially concerning for young calves during transport when they are most susceptible to developing disease. Despite years of extensive study, managing BRD remains challenging as its aetiology involves complex interactions between pathogens, environmental and host factors. While at the beginning of the twentieth century, scientists believed that BRD was only caused by bacterial infections (“bovine pasteurellosis”), we now know that viruses play a key role in BRD induction. Mixtures of pathogenic bacteria and viruses are frequently isolated from respiratory secretions of animals with respiratory illness. The increased diagnostic screening data has changed our understanding of pathogens contributing to BRD development. In this review, we aim to comprehensively examine experimental evidence from all existing studies performed to understand coinfections between respiratory pathogens in cattle. Despite the fact that pneumonia has not always been successfully reproduced by in vivo calf modelling, several studies attempted to investigate the clinical significance of interactions between different pathogens. The most studied model of pneumonia induction has been reproduced by a primary viral infection followed by a secondary bacterial superinfection, with strong evidence suggesting this could potentially be one of the most common scenarios during BRD onset. Different in vitro studies indicated that viral priming may increase bacterial adherence and colonization of the respiratory tract, suggesting a possible mechanism underpinning bronchopneumonia onset in cattle. In addition, a few in vivo studies on viral coinfections and bacterial coinfections demonstrated that a primary viral infection could also increase the pathogenicity of a secondary viral infection and, similarly, dual infections with two bacterial pathogens could increase the severity of BRD lesions. Therefore, different scenarios of pathogen dynamics could be hypothesized for BRD onset which are not limited to a primary viral infection followed by a secondary bacterial superinfection.
Journal Article
The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks
The gut and lungs are anatomically distinct, but potential anatomic communications and complex pathways involving their respective microbiota have reinforced the existence of a gut-lung axis (GLA). Compared to the better-studied gut microbiota, the lung microbiota, only considered in recent years, represents a more discreet part of the whole microbiota associated to human hosts. While the vast majority of studies focused on the bacterial component of the microbiota in healthy and pathological conditions, recent works have highlighted the contribution of fungal and viral kingdoms at both digestive and respiratory levels. Moreover, growing evidence indicates the key role of inter-kingdom crosstalks in maintaining host homeostasis and in disease evolution. In fact, the recently emerged GLA concept involves host-microbe as well as microbe-microbe interactions, based both on localized and long-reaching effects. GLA can shape immune responses and interfere with the course of respiratory diseases. In this review, we aim to analyze how the lung and gut microbiota influence each other and may impact on respiratory diseases. Due to the limited knowledge on the human virobiota, we focused on gut and lung bacteriobiota and mycobiota, with a specific attention on inter-kingdom microbial crosstalks which are able to shape local or long-reached host responses within the GLA.
Journal Article
Bovine respiratory microbiota of feedlot cattle and its association with disease
Bovine respiratory disease (BRD), as one of the most common and costly diseases in the beef cattle industry, has significant adverse impacts on global food security and the economic stability of the industry. The bovine respiratory microbiome is strongly associated with health and disease and may provide insights for alternative therapy when treating BRD. The niche-specific microbiome communities that colonize the inter-surface of the upper and the lower respiratory tract consist of a dynamic and complex ecological system. The correlation between the disequilibrium in the respiratory ecosystem and BRD has become a hot research topic. Hence, we summarize the pathogenesis and clinical signs of BRD and the alteration of the respiratory microbiota. Current research techniques and the biogeography of the microbiome in the healthy respiratory tract are also reviewed. We discuss the process of resident microbiota and pathogen colonization as well as the host immune response. Although associations between the microbiota and BRD have been revealed to some extent, interpreting the development of BRD in relation to respiratory microbial dysbiosis will likely be the direction for upcoming studies, which will allow us to better understand the importance of the airway microbiome and its contributions to animal health and performance.
Journal Article