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Transmission potential of Streptococcus pyogenes during a controlled human infection trial of pharyngitis

by Thomas, Hannah M. M. , Lansbury, Nina , Carapetis, Jonathan R. , Osowicki, Joshua , Bowen, Asha C. , Hla, Thel K. , Wong, Bernadette , Enkel, Stephanie L. , Pickering, Janessa , Steer, Andrew , Barnett, Timothy C. , Manning, Laurens

in acute rheumatic fever / Adult / Anti-Bacterial Agents - pharmacology / Anti-Bacterial Agents - therapeutic use / Coronaviruses / COVID-19 / Design / Disease control / Disease transmission / Environmental Microbiology / environmental transmission of microbes / Epidemics / Experiments / Female / Fomites / Health care / human infection study / Humans / Humidity / infection prevention / Infections / Male / Masks / Morbidity / Pathogens / Penicillin / Penicillins - pharmacology / Penicillins - therapeutic use / Pharyngitis / Pharyngitis - microbiology / Polymerase chain reaction / Research Article / rheumatic heart disease / Streptococcal Infections - microbiology / Streptococcal Infections - transmission / Streptococcus infections / Streptococcus pyogenes / Streptococcus pyogenes - drug effects / Streptococcus pyogenes - genetics / Streptococcus pyogenes - isolation & purification / Whole Genome Sequencing / Young Adult

2024

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Transmission potential of Streptococcus pyogenes during a controlled human infection trial of pharyngitis

2024

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Transmission potential of Streptococcus pyogenes during a controlled human infection trial of pharyngitis

2024

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Journal Article

Transmission potential of Streptococcus pyogenes during a controlled human infection trial of pharyngitis

Thomas, Hannah M. M.,

Lansbury, Nina,

Carapetis, Jonathan R.,

Osowicki, Joshua,

Bowen, Asha C.,

Hla, Thel K.,

Wong, Bernadette,

Enkel, Stephanie L.,

Pickering, Janessa,

Steer, Andrew,

Barnett, Timothy C.,

Manning, Laurens

2024

Overview

Streptococcus pyogenes remains a significant driver of morbidity and mortality, particularly in under-resourced settings. Understanding the transmission modalities of this pathogen is essential to ensuring the success of prevention methods. This proposed paper presents a nascent attempt to determine the transmission potential of Streptococcus pyogenes nested within a larger controlled human infection model.

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Publisher

American Society for Microbiology

Subject

acute rheumatic fever

/ Adult

/ Anti-Bacterial Agents - pharmacology

/ Anti-Bacterial Agents - therapeutic use

/ Coronaviruses

/ COVID-19

/ Design