Journal Article

Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 and Procalcitonin Can Reflect Sepsis Severity and Predict Prognosis: A Prospective Cohort Study

Liu, Jian, Li, Guangping, Chen, Bing, Wang, Hongxia, Li, Zhenyu

2014

Overview

Objective. To investigate the prognostic significance of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin (PCT), N-terminal probrain natriuretic peptide (NT-pro-BNP), C-reactive protein (CRP), cytokines, and clinical severity scores in patients with sepsis. Methods. A total of 102 patients with sepsis were divided into survival group ( n = 60 ) and nonsurvival group ( n = 42 ) based on 28-day mortality. Serum levels of biomarkers and cytokines were measured on days 1, 3, and 5 after admission to an ICU, meanwhile the acute physiology and chronic health evaluation II (APACHE II) and sequential organ failure assessment (SOFA) scores were calculated. Results. Serum sTREM-1, PCT, and IL-6 levels of patients in the nonsurvival group were significantly higher than those in the survival group on day 1 ( P < 0.01 ). The area under a ROC curve for the prediction of 28 day mortality was 0.792 for PCT, 0.856 for sTREM-1, 0.953 for SOFA score, and 0.923 for APACHE II score. Multivariate logistic analysis showed that serum baseline sTREM-1 PCT levels and SOFA score were the independent predictors of 28-day mortality. Serum PCT, sTREM-1, and IL-6 levels showed a decrease trend over time in the survival group ( P < 0.05 ). Serum NT-pro-BNP levels showed the predictive utility from days 3 and 5 ( P < 0.05 ). Conclusion. In summary, elevated serum sTREM-1 and PCT levels provide superior prognostic accuracy to other biomarkers. Combination of serum sTREM-1 and PCT levels and SOFA score can offer the best powerful prognostic utility for sepsis mortality.

• Publisher: Hindawi Limiteds,Hindawi Publishing Corporation,John Wiley & Sons, Inc,Wiley
• Subject: Adult / Aged / Biomarkers - blood / C-Reactive Protein - metabolism / Calcitonin / Calcitonin - blood / Calcitonin Gene-Related Peptide / Clinical Study / Female / Gene expression / Health aspects / Humans / Identification and classification / Intensive Care Units / Interleukin-6 - blood / Male / Membrane Glycoproteins - blood / Middle Aged / Multivariate Analysis / Natriuretic Peptide, Brain - blood / Peptide Fragments - blood / Physiological aspects / Prognosis / Prospective Studies / Protein Precursors - blood / Receptors, Immunologic - blood / ROC Curve / Sepsis / Sepsis - blood / Sepsis - mortality / Time Factors / Treatment Outcome / Triggering Receptor Expressed on Myeloid Cells-1