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The relationship between central visual field sensitivity and macular ganglion cell/inner plexiform layer thickness in glaucoma
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The relationship between central visual field sensitivity and macular ganglion cell/inner plexiform layer thickness in glaucoma
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Journal Article
The relationship between central visual field sensitivity and macular ganglion cell/inner plexiform layer thickness in glaucoma
2017
Overview
AimsTo explore the correlation of local macular ganglion cell/inner plexiform layer (GC/IPL) thickness measurements with sensitivity at individual test locations on the central 10-2 visual fields (VFs) in patients with glaucoma.MethodsOne hundred thirty-seven eyes of 125 patients with spectral domain optical coherence tomography (OCT) and 10-2 VFs were included. The exported thickness matrices (200×200) of GC/IPL measurements were centred on the fovea. Total deviation values at each test location were correlated with the 20 000 GC/IPL thickness measurements in the corresponding inferior or superior hemiretina, and areas of highest correlation were plotted. Macular structure–function relationships were also examined between six wedge-shaped GC/IPL sectors and the corresponding VF clusters. A multivariate model was built to identify the 10-2 VF test locations associated with each GC/IPL sector thickness.ResultsAverage mean deviation on 10-2 VFs was −9.2±6.1 dB. The 10-2 VF test points demonstrated correlations with GC/IPL thickness in localised arcuate patterns mostly limited within the central 4.8×4.0 mm measurement ellipse (ρ=0.43–0.74, p<0.05 for all). Twenty-one test points of the 10-2 VF were the best predictors of sectoral GC/IPL thickness. Sectoral VF-OCT correlations were high (ρ=0.53–0.66, p<0.001) and did not significantly change after adjusting for retinal GC displacement (p>0.05).ConclusionsMacular OCT/VF relationships have localised arcuate characteristics in the central region of the macula. Given the overlapping nature of structure–function relationships, a smaller number of VF test locations may be used to summarise macular functional damage.Trial registration numberNCT01742819.
Publisher
BMJ Publishing Group LTD
Subject
/ Disease
/ Exports
/ Female
/ Glaucoma
/ Glaucoma - diagnostic imaging
/ Humans
/ Macula Lutea - diagnostic imaging
/ Male
/ Optics
/ Retina
/ Retinal Diseases - diagnostic imaging
/ Retinal Diseases - pathology
/ Retinal Diseases - physiopathology
/ Retinal Ganglion Cells - pathology
