Asset Details
Do you wish to reserve the book?
High-resolution mapping of meiotic crossovers and non-crossovers in yeast
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
High-resolution mapping of meiotic crossovers and non-crossovers in yeast
Do you wish to request the book?
High-resolution mapping of meiotic crossovers and non-crossovers in yeast
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
High-resolution mapping of meiotic crossovers and non-crossovers in yeast
2008
Overview
Meiotic recombination has a central role in the evolution of sexually reproducing organisms. The two recombination outcomes, crossover and non-crossover, increase genetic diversity, but have the potential to homogenize alleles by gene conversion. Whereas crossover rates vary considerably across the genome, non-crossovers and gene conversions have only been identified in a handful of loci. To examine recombination genome wide and at high spatial resolution, we generated maps of crossovers, crossover-associated gene conversion and non-crossover gene conversion using dense genetic marker data collected from all four products of fifty-six yeast (Saccharomyces cerevisiae) meioses. Our maps reveal differences in the distributions of crossovers and non-crossovers, showing more regions where either crossovers or non-crossovers are favoured than expected by chance. Furthermore, we detect evidence for interference between crossovers and non-crossovers, a phenomenon previously only known to occur between crossovers. Up to 1% of the genome of each meiotic product is subject to gene conversion in a single meiosis, with detectable bias towards GC nucleotides. To our knowledge the maps represent the first high-resolution, genome-wide characterization of the multiple outcomes of recombination in any organism. In addition, because non-crossover hotspots create holes of reduced linkage within haplotype blocks, our results stress the need to incorporate non-crossovers into genetic linkage analysis.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Biological and medical sciences
/ Chromosomes, Fungal - genetics
/ Classical genetics, quantitative genetics, hybrids
/ Crossing Over, Genetic - genetics
/ crossover-associated gene conversion
/ cytology
/ DNA-Binding Proteins - genetics
/ Fundamental and applied biological sciences. Psychology
/ Gene Expression Regulation, Fungal
/ genetics
/ Genetics of eukaryotes. Biological and molecular evolution
/ Genomics
/ Genotype
/ Humanities and Social Sciences
/ Meiosis
/ Methods
/ Mutation
/ non-crossover gene conversion
/ Saccharomyces cerevisiae - cytology
/ Saccharomyces cerevisiae - genetics
/ Saccharomyces cerevisiae Proteins
/ Saccharomyces cerevisiae Proteins - genetics
/ Science
/ Yeast
/ Yeasts
