Journal Article

Sovateltide (ILR-1620) Improves Motor Function and Reduces Hyperalgesia in a Rat Model of Spinal Cord Injury

Iacovidou, Nicoletta, Mavridi, Artemis, Mavridis, Theodoros, Gkiokas, George, Karampela, Eleftheria, Galanos, Antonis, Xanthos, Theodoros

2024

Overview

Background Spinal cord injury (SCI) presents a major global health challenge, with rising incidence rates and substantial disability. Although progress has been made in understanding SCI’s pathophysiology and early management, there is still a lack of effective treatments to mitigate long-term consequences. This study investigates the potential of sovateltide, a selective endothelin B receptor agonist, in improving clinical outcomes in an acute SCI rat model. Methods Thirty male Sprague–Dawley rats underwent sham surgery (group A) or SCI and treated with vehicle (group B) or sovateltide (group C). Clinical tests, including Basso, Beattie, and Bresnahan scoring, inclined plane, and allodynia testing with von Frey hair, were performed at various time points. Statistical analyses assessed treatment effects. Results Sovateltide administration significantly improved motor function, reducing neurological deficits and enhancing locomotor recovery compared with vehicle-treated rats, starting from day 7 post injury. Additionally, the allodynic threshold improved, suggesting antinociceptive properties. Notably, the sovateltide group demonstrated sustained recovery, and even reached preinjury performance levels, whereas the vehicle group plateaued. Conclusions This study suggests that sovateltide may offer neuroprotective effects, enhancing neurogenesis and angiogenesis. Furthermore, it may possess anti-inflammatory and antinociceptive properties. Future clinical trials are needed to validate these findings, but sovateltide shows promise as a potential therapeutic strategy to improve functional outcomes in SCI. Sovateltide, an endothelin B receptor agonist, exhibits neuroprotective properties, enhancing motor recovery and ameliorating hyperalgesia in a rat SCI model. These findings could pave the way for innovative pharmacological interventions for SCI in clinical settings.

• Publisher: Springer US,Springer Nature B.V
• Subject: Animals / Antibiotics / Critical Care Medicine / Disease Models, Animal / Endothelins - pharmacology / Experiments / Hyperalgesia - drug therapy / Hyperalgesia - etiology / Intensive / Internal Medicine / Laboratory animals / Male / Medical research / Medicine / Medicine & Public Health / Nervous system / Neurology / Neurosurgery / Non-pharmacological intervention / Original Work / Peptide Fragments / Rats / Rats, Sprague-Dawley / Receptor, Endothelin B - drug effects / Recovery of Function - drug effects / Spinal cord injuries / Spinal Cord Injuries - complications / Spinal Cord Injuries - drug therapy / Surgery / Vertebrae