Journal Article

Emodin prevents hypoxic-ischemic neuronal injury Involvement of the activin A pathway

Hongliang Guo Xiaoran Shen Ye Xu Junliang Yuan Dongming Zhao Wenli Hu

2013

Overview

Emodin, an extract of dried rhizomes and the root of the Rhizoma Polygoni Cuspidati, can protect neurons from hypoxic-ischemic brain damage. This study aimed to verify the underlying mechanism After PC12 cells had differentiated into neuron-like cells under the induction of mouse nerve growth factor, cells were subjected to oxygen-glucose deprivation and treated with emodin. Results shewed that the viability of neuron-like cells cultured under an ischemia-hypoxia environment decreased, while the expression of activin A and caspase-3 in cells increased. Emodin raised the survival rate of oxygen-glucose deprived neuron-like cells~ increased activin A expression, and decreased caspase-3 expression. Experimental findings indicate that emodin can inhibit neuronal apoptosis and alleviate the injury of nerve cells after oxygen-glucose deprivation through the activin A pathway.

• Publisher: Department of Neurology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China,Beihua University, Jilin 132001, Jilin Province, China%Jilin Municipal Central Hospital, Jilin 132001, Jilin Province, China%Jilin Medical College, Jilin 132001, Jilin Province, China%Department of Neurology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China%Beihua University, Jilin 132001, Jilin Province, China,Medknow Publications & Media Pvt Ltd
• Subject: caspase-3 / Research and Report : Traditional Chinese Medicine and Neural Regeneration / 大黄素 / 激活素 / 神经元损伤 / 神经元样细胞 / 神经生长因子 / 缺氧缺血 / 缺血性脑损伤