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Structures shed light on prostanoid signaling
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Journal Article
Structures shed light on prostanoid signaling
2019
Overview
Prostanoids signal through G-protein-coupled receptors to regulate diverse physiological processes. Structures of three prostanoid receptors in inactive and active conformations now uncover the molecular determinants of ligand recognition and receptor activation and offer new opportunities for drug discovery.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Chemistry and Materials Science
/ Humans
/ Ligands
/ Lipids
/ Proteins
/ Receptors, Prostaglandin E, EP3 Subtype - agonists
/ Receptors, Prostaglandin E, EP3 Subtype - chemistry
/ Receptors, Prostaglandin E, EP3 Subtype - metabolism
/ Receptors, Prostaglandin E, EP4 Subtype - agonists
/ Receptors, Prostaglandin E, EP4 Subtype - chemistry
/ Receptors, Prostaglandin E, EP4 Subtype - metabolism
/ Receptors, Thromboxane A2, Prostaglandin H2 - antagonists & inhibitors
/ Receptors, Thromboxane A2, Prostaglandin H2 - chemistry
