Journal Article

Fyn Kinase Activity and Its Role in Neurodegenerative Disease Pathology: a Potential Universal Target?

Sivasankar, Srisankavi, Mustafa, Sanam, Collins-Praino, Lyndsey E., Guglietti, Bianca, Corrigan, Frances

2021

Overview

Fyn is a non-receptor tyrosine kinase belonging to the Src family of kinases (SFKs) which has been implicated in several integral functions throughout the central nervous system (CNS), including myelination and synaptic transmission. More recently, Fyn dysfunction has been associated with pathological processes observed in neurodegenerative diseases, such as multiple sclerosis (MS), Alzheimer’s disease (AD) and Parkinson’s disease (PD). Neurodegenerative diseases are amongst the leading cause of death and disability worldwide and, due to the ageing population, prevalence is predicted to rise in the coming years. Symptoms across neurodegenerative diseases are both debilitating and degenerative in nature and, concerningly, there are currently no disease-modifying therapies to prevent their progression. As such, it is important to identify potential new therapeutic targets. This review will outline the role of Fyn in normal/homeostatic processes, as well as degenerative/pathological mechanisms associated with neurodegenerative diseases, such as demyelination, pathological protein aggregation, neuroinflammation and cognitive dysfunction.

• Publisher: Springer US,Springer Nature B.V
• Subject: Aging / Alzheimer Disease - drug therapy / Alzheimer Disease - enzymology / Alzheimer Disease - physiopathology / Alzheimer's disease / Amyloid beta-Peptides - metabolism / Benzamides - pharmacology / Benzamides - therapeutic use / Biomedical and Life Sciences / Biomedicine / Cell Biology / Central nervous system / Central Nervous System - enzymology / Cognitive ability / Dasatinib - pharmacology / Dasatinib - therapeutic use / Demyelination / Fyn protein / Humans / Inflammation / Kinases / Molecular Targeted Therapy / Movement disorders / Multiple sclerosis / Multiple Sclerosis - drug therapy / Multiple Sclerosis - enzymology / Myelin Sheath - physiology / Myelination / Nerve Tissue Proteins - drug effects / Nerve Tissue Proteins - physiology / Neurobiology / Neurodegenerative diseases / Neurodegenerative Diseases - drug therapy / Neurodegenerative Diseases - enzymology / Neurodegenerative Diseases - physiopathology / Neurology / Neurosciences / Oligodendroglia - metabolism / Parkinson Disease - drug therapy / Parkinson Disease - enzymology / Parkinson Disease - physiopathology / Parkinson's disease / Piperidines - pharmacology / Piperidines - therapeutic use / Protein interaction / Protein-tyrosine kinase receptors / Proto-Oncogene Proteins c-fyn - antagonists & inhibitors / Proto-Oncogene Proteins c-fyn - drug effects / Proto-Oncogene Proteins c-fyn - physiology / PrPC Proteins - metabolism / Pyridines - pharmacology / Pyridines - therapeutic use / Receptors, N-Methyl-D-Aspartate - metabolism / Synaptic transmission / T-Cell Antigen Receptor Specificity / T-Lymphocyte Subsets - enzymology / T-Lymphocyte Subsets - immunology / tau Proteins - metabolism / Thiazoles - pharmacology / Thiazoles - therapeutic use