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Trial of Beremagene Geperpavec (B-VEC) for Dystrophic Epidermolysis Bullosa
by
Gonzalez, Franshesca
, Krishnan, Suma
, Agostini, Brittani
, Guide, Shireen V.
, Chen, Hubert
, Gonzalez, Mercedes E.
, Bağcı, I. Sinem
, Chitra, Surya
, Marinkovich, M. Peter
, Kammerman, Lisa A.
, Parry, Trevor J.
, Quesada Sanchez, Lori
, Steimer, Molly
, Kapadia, Binoy
, Feeney, Gloria
, Van Ligten, Matthew
, Sridhar, Kunju
in
Administration, Topical
/ Age
/ Clinical trials
/ Collagen (type I)
/ Collagen Type VII - administration & dosage
/ Collagen Type VII - adverse effects
/ Collagen Type VII - genetics
/ Collagen Type VII - metabolism
/ Dermatology
/ Dermatology General
/ Design
/ Drug dosages
/ Dystrophic epidermolysis bullosa
/ Epidermolysis bullosa
/ Epidermolysis Bullosa Dystrophica - drug therapy
/ Epidermolysis Bullosa Dystrophica - genetics
/ Epidermolysis Bullosa Dystrophica - metabolism
/ FDA approval
/ Gene therapy
/ Genetic Therapy - adverse effects
/ Genetic Therapy - methods
/ Genetics
/ Genetics General
/ Herpes simplex
/ Herpes viruses
/ Humans
/ Pain
/ Patients
/ Pediatrics
/ Pediatrics General
/ Placebos
/ Pruritus
/ Pruritus - chemically induced
/ Questionnaires
/ Side effects
/ Skin
/ Skin diseases
/ Wound healing
/ Wound Healing - drug effects
/ Wound Healing - genetics
2022
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Trial of Beremagene Geperpavec (B-VEC) for Dystrophic Epidermolysis Bullosa
by
Gonzalez, Franshesca
, Krishnan, Suma
, Agostini, Brittani
, Guide, Shireen V.
, Chen, Hubert
, Gonzalez, Mercedes E.
, Bağcı, I. Sinem
, Chitra, Surya
, Marinkovich, M. Peter
, Kammerman, Lisa A.
, Parry, Trevor J.
, Quesada Sanchez, Lori
, Steimer, Molly
, Kapadia, Binoy
, Feeney, Gloria
, Van Ligten, Matthew
, Sridhar, Kunju
in
Administration, Topical
/ Age
/ Clinical trials
/ Collagen (type I)
/ Collagen Type VII - administration & dosage
/ Collagen Type VII - adverse effects
/ Collagen Type VII - genetics
/ Collagen Type VII - metabolism
/ Dermatology
/ Dermatology General
/ Design
/ Drug dosages
/ Dystrophic epidermolysis bullosa
/ Epidermolysis bullosa
/ Epidermolysis Bullosa Dystrophica - drug therapy
/ Epidermolysis Bullosa Dystrophica - genetics
/ Epidermolysis Bullosa Dystrophica - metabolism
/ FDA approval
/ Gene therapy
/ Genetic Therapy - adverse effects
/ Genetic Therapy - methods
/ Genetics
/ Genetics General
/ Herpes simplex
/ Herpes viruses
/ Humans
/ Pain
/ Patients
/ Pediatrics
/ Pediatrics General
/ Placebos
/ Pruritus
/ Pruritus - chemically induced
/ Questionnaires
/ Side effects
/ Skin
/ Skin diseases
/ Wound healing
/ Wound Healing - drug effects
/ Wound Healing - genetics
2022
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Trial of Beremagene Geperpavec (B-VEC) for Dystrophic Epidermolysis Bullosa
by
Gonzalez, Franshesca
, Krishnan, Suma
, Agostini, Brittani
, Guide, Shireen V.
, Chen, Hubert
, Gonzalez, Mercedes E.
, Bağcı, I. Sinem
, Chitra, Surya
, Marinkovich, M. Peter
, Kammerman, Lisa A.
, Parry, Trevor J.
, Quesada Sanchez, Lori
, Steimer, Molly
, Kapadia, Binoy
, Feeney, Gloria
, Van Ligten, Matthew
, Sridhar, Kunju
in
Administration, Topical
/ Age
/ Clinical trials
/ Collagen (type I)
/ Collagen Type VII - administration & dosage
/ Collagen Type VII - adverse effects
/ Collagen Type VII - genetics
/ Collagen Type VII - metabolism
/ Dermatology
/ Dermatology General
/ Design
/ Drug dosages
/ Dystrophic epidermolysis bullosa
/ Epidermolysis bullosa
/ Epidermolysis Bullosa Dystrophica - drug therapy
/ Epidermolysis Bullosa Dystrophica - genetics
/ Epidermolysis Bullosa Dystrophica - metabolism
/ FDA approval
/ Gene therapy
/ Genetic Therapy - adverse effects
/ Genetic Therapy - methods
/ Genetics
/ Genetics General
/ Herpes simplex
/ Herpes viruses
/ Humans
/ Pain
/ Patients
/ Pediatrics
/ Pediatrics General
/ Placebos
/ Pruritus
/ Pruritus - chemically induced
/ Questionnaires
/ Side effects
/ Skin
/ Skin diseases
/ Wound healing
/ Wound Healing - drug effects
/ Wound Healing - genetics
2022
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Trial of Beremagene Geperpavec (B-VEC) for Dystrophic Epidermolysis Bullosa
Journal Article
Trial of Beremagene Geperpavec (B-VEC) for Dystrophic Epidermolysis Bullosa
2022
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Overview
This genetic blistering disease is the result of mutations in
COL7A1
, which encodes type VII collagen. Topical HSV-1 gene therapy delivering
COL7A1
resulted in greater wound healing at 6 months than placebo.
Publisher
Massachusetts Medical Society
Subject
/ Age
/ Collagen Type VII - administration & dosage
/ Collagen Type VII - adverse effects
/ Collagen Type VII - genetics
/ Collagen Type VII - metabolism
/ Design
/ Dystrophic epidermolysis bullosa
/ Epidermolysis Bullosa Dystrophica - drug therapy
/ Epidermolysis Bullosa Dystrophica - genetics
/ Epidermolysis Bullosa Dystrophica - metabolism
/ Genetic Therapy - adverse effects
/ Genetics
/ Humans
/ Pain
/ Patients
/ Placebos
/ Pruritus
/ Pruritus - chemically induced
/ Skin
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