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Ibuprofen Therapy Resulted in Significantly Decreased Tissue Bacillary Loads and Increased Survival in a New Murine Experimental Model of Active Tuberculosis
by
Vilaplana, Cristina
, Cardona, Pere-Joan
, Diaz, Jorge
, Marzo, Elena
, Tapia, Gustavo
, Garcia, Vanesa
in
Animal models
/ Animals
/ Anti-Inflammatory Agents - pharmacology
/ Antiinflammatories
/ BACTERIA
/ Biological and medical sciences
/ Disease Models, Animal
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Ibuprofen - pharmacology
/ Infections
/ Infectious diseases
/ Lesions
/ Lungs
/ Medical sciences
/ Mice
/ Mice, Inbred C3H
/ Microbiology
/ Mycobacterium tuberculosis
/ Mycobacterium tuberculosis - drug effects
/ Mycobacterium tuberculosis - growth & development
/ Neutrophils
/ Tuberculosis
/ Tuberculosis - drug therapy
/ Tuberculosis - microbiology
2013
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Ibuprofen Therapy Resulted in Significantly Decreased Tissue Bacillary Loads and Increased Survival in a New Murine Experimental Model of Active Tuberculosis
by
Vilaplana, Cristina
, Cardona, Pere-Joan
, Diaz, Jorge
, Marzo, Elena
, Tapia, Gustavo
, Garcia, Vanesa
in
Animal models
/ Animals
/ Anti-Inflammatory Agents - pharmacology
/ Antiinflammatories
/ BACTERIA
/ Biological and medical sciences
/ Disease Models, Animal
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Ibuprofen - pharmacology
/ Infections
/ Infectious diseases
/ Lesions
/ Lungs
/ Medical sciences
/ Mice
/ Mice, Inbred C3H
/ Microbiology
/ Mycobacterium tuberculosis
/ Mycobacterium tuberculosis - drug effects
/ Mycobacterium tuberculosis - growth & development
/ Neutrophils
/ Tuberculosis
/ Tuberculosis - drug therapy
/ Tuberculosis - microbiology
2013
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Ibuprofen Therapy Resulted in Significantly Decreased Tissue Bacillary Loads and Increased Survival in a New Murine Experimental Model of Active Tuberculosis
by
Vilaplana, Cristina
, Cardona, Pere-Joan
, Diaz, Jorge
, Marzo, Elena
, Tapia, Gustavo
, Garcia, Vanesa
in
Animal models
/ Animals
/ Anti-Inflammatory Agents - pharmacology
/ Antiinflammatories
/ BACTERIA
/ Biological and medical sciences
/ Disease Models, Animal
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Ibuprofen - pharmacology
/ Infections
/ Infectious diseases
/ Lesions
/ Lungs
/ Medical sciences
/ Mice
/ Mice, Inbred C3H
/ Microbiology
/ Mycobacterium tuberculosis
/ Mycobacterium tuberculosis - drug effects
/ Mycobacterium tuberculosis - growth & development
/ Neutrophils
/ Tuberculosis
/ Tuberculosis - drug therapy
/ Tuberculosis - microbiology
2013
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Ibuprofen Therapy Resulted in Significantly Decreased Tissue Bacillary Loads and Increased Survival in a New Murine Experimental Model of Active Tuberculosis
Journal Article
Ibuprofen Therapy Resulted in Significantly Decreased Tissue Bacillary Loads and Increased Survival in a New Murine Experimental Model of Active Tuberculosis
2013
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Overview
C3HeB/FeJ mice infected with Mycobacterium tuberculosis were used in an experimental animal model mimicking active tuberculosis in humans to evaluate the effect of antiinflammatory agents. No other treatment but ibuprofen was given, and it was administered when the animals' health started to deteriorate. Animals treated with ibuprofen had statistically significant decreases in the size and number of lung lesions, decreases in the bacillary load, and improvements in survival, compared with findings for untreated animals. Because antiinflammatory agents are already on the market, further clinical trials should be done to evaluate this effect in humans as soon as possible, to determine their suitability as coadjuvant tuberculosis treatment.
Publisher
Oxford University Press
Subject
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