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The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes
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The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes
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Journal Article
The clinical-chemical screen in the Munich ENU Mouse Mutagenesis Project: screening for clinically relevant phenotypes
2000
Overview
The Munich ENU Mouse Mutagenesis Project within the German Human Genome Project is a phenotype-driven approach to produce, identify, and characterize new mouse mutants (Hrabe de Angelis and Balling 1998). The focus of the clinical-chemical screen is on laboratory diagnostic procedures (mainly bloodbased) suitable to detect hematological changes, defects of various organ systems, and changes in metabolic pathways and electrolyte homeostasis. The methods used are appropriate routine procedures, allowing the screening of large numbers of mice for a broad spectrum of clinical-chemical and hematological parameters. Since most inherited metabolic disorders in humans are known to lead directly or indirectly via altered organ function to changes in the parameters investigated (Fernandes et al. 1995; Saudubray and Charpentier 1995), this screen provides a comprehensive investigation of clinical phenotypes with known counterparts in humans.
Publisher
Springer Nature B.V
