Journal Article

Lichen planus after COVID-19 infection and vaccination

Daveluy, Steven, Zou, Henry

2023

Overview

Lichen planus (LP) is an inflammatory disorder believed to result from CD8 + cytotoxic T -cell (CTL)-mediated autoimmune reactions against basal keratinocytes. We present a review of LP following COVID-19 infection and vaccination. Literature searches were conducted on PubMed and Google Scholar from 2019 to 7/2022. 36 articles were selected based on subject relevance, and references within articles were also screened. 39 cases of post-vaccination LP and 6 cases of post-infection LP were found among case reports and case series. 152 cases of post-vaccination LP and 12 cases of post-infection LP were found in retrospective and prospective studies. LP is a rare complication of COVID-19 infection and vaccination that may be mediated by overstimulation of T -cell responses and proinflammatory cytokine production. However, it does not represent a limitation against COVID-19 vaccination, and the benefits of vaccination considerably outweigh the risks.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Antigens / Apoptosis / Case reports / CD8 antigen / Cohort analysis / Conflicts of interest / Contraindications / COVID-19 / COVID-19 - complications / COVID-19 - prevention & control / COVID-19 vaccines / COVID-19 Vaccines - adverse effects / Cytokines / Cytotoxicity / Dermatology / Diabetes / Funding / Humans / Hypertension / Infections / Inflammatory diseases / Keratinocytes / Lichen planus / Lichen Planus - etiology / Lichen Planus, Oral / Lymphocytes T / Medicine / Medicine & Public Health / Observational studies / Pathogenesis / Prospective Studies / Proteins / Retrospective Studies / Review / Severe acute respiratory syndrome coronavirus 2 / Tumor necrosis factor-TNF / Vaccination / Vitamin deficiency / Vitiligo